A5026672123- Conducting polymers and applications
- Organic Electronics and Photovoltaics
- Advanced Sensor and Energy Harvesting Materials
- Robotics and Sensor-Based Localization
- Nanoplatforms for cancer theranostics
- Perovskite Materials and Applications
- RNA modifications and cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- MicroRNA in disease regulation
- Advanced Image and Video Retrieval Techniques
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- Organic Light-Emitting Diodes Research
- Nanomaterials and Printing Technologies
- Cancer, Lipids, and Metabolism
- Photodynamic Therapy Research Studies
- Indoor and Outdoor Localization Technologies
- Nanoparticle-Based Drug Delivery
- Thermal Analysis in Power Transmission
- Advanced Photocatalysis Techniques
- Advanced Vision and Imaging
- Lightning and Electromagnetic Phenomena
- Immune cells in cancer
Beijing University of Chemical Technology
2022-2024
The First Affiliated Hospital, Sun Yat-sen University
2019-2024
Zhongshan Hospital
2019-2024
Fudan University
2019-2024
Sun Yat-sen University
2019-2024
Shanghai Institute of Hematology
2020-2023
Yanshan University
2020
University of Shanghai for Science and Technology
2020
Central South University
2019-2020
Georgia Institute of Technology
2013-2016
Background and Aims: Liver fibrosis is a leading indicator for increased mortality long-term comorbidity in NASH. Activation of HSCs excessive extracellular matrix production are the hallmarks liver fibrogenesis. Tyrosine kinase receptor (TrkB) multifunctional that participates neurodegenerative disorders. However, paucity literature available about TrkB function fibrosis. Herein, regulatory network therapeutic potential were explored progression hepatic Methods Results: The protein level...
Ultraflexible organic solar cells (OSCs) with both high power conversion efficiency (PCE) and good mechanical robustness are still challenging, in which flexible transparent composite electrodes (FTCEs, substrate-cum-electrodes) play critical roles. Here, an ultrathin FTCE (∼9 μm) via semi-embedding a silver nanowire electrode colorless polyimide (CPI) substrate was developed, simultaneously possessed outstanding performance such as low square resistance (Rsq ∼ 12.7 Ω sq-1), optical...
Abstract Nickel oxide (NiO x ) has garnered considerable attention as a prospective hole‐transporting layer (HTL) in organic solar cells (OSCs), offering potential solution to the stability challenges posed by traditional HTL, PEDOT:PSS, arising from acidity and hygroscopicity. Nevertheless, lower work function (WF) of NiO relative donor polymers reduces charge injection efficiency OSCs. Herein, nanoparticles are tailored through rare earth doping optimize WF impact ionic radius on their...
Abstract Solvent additives are pivotal for enhancing the morphology, efficiency, and stability of organic solar cells (OSCs). However, widely used additive, 1,8‐diiodooctane (DIO), has drawbacks like harmful halogen content potential OSC degradation. To address these issues, novel non‐halogenated, thienyl‐alkyl‐thienyl structural solvent additives—DTP, DTH, DTN—featuring varying alkyl linker lengths (CH 2 ) 3 , 6 9 respectively introduced. Additives with longer linkers, DTH DTN, effectively...
Incorporating flexible insulating polymers is a straightforward strategy to enhance the mechanical properties of rigid conjugated polymers, enabling their use in electronic devices. However, maintaining characteristics simultaneously challenging due poor miscibility between and polymers. This study introduces carboxylation as an effective with via surface energy modulation hydrogen bonding. The carboxylated elastomer, synthesized thiol-ene click reaction, closely matches polymer....
Not all measured features in SLAM/SfM contribute to accurate localization during the estimation process, thus it is sensible utilize only those that do. This paper describes a method for selecting subset of are high utility process. It derived by examining observability SLAM and, being complimentary easily integrates into existing systems. The measure formulated with temporal and instantaneous indices. Efficient computation strategies indices described based on incremental singular value...
Lipid metabolism reprogramming is a recognized hallmark of cancer cells. Identification the underlying regulators metabolic in esophageal squamous cell carcinoma (ESCC) could uncover potential therapeutic targets to improve treatment. Here, we demonstrated that pre-mRNA processing factor 19 (PRP19) mediates lipid ESCC. Expression PRP19 was significantly upregulated multiple ESCC cohorts and correlated with poor clinical prognosis. promoted proliferation vitro vivo. Upregulation enhanced...
Abstract Currently, much of the manual labor needed to generate as‐built building information models (BIMs) existing facilities is spent converting raw point cloud data sets (PCDs) BIM descriptions. Automating PCD conversion process can drastically reduce cost generating BIMs. Due widespread existence planar structures in civil infrastructures, detecting and extracting patches from PCDs a fundamental step pipeline However, methods cannot effectively address both automatically infrastructure...
Tumor-associated macrophages (TAM) are immunosuppressive cells that contribute to impaired anti-cancer immunity. Iron plays a critical role in regulating macrophage function. However, it is still elusive whether can drive the functional polarization of context cancer and how tumor affect iron-handing properties TAM. In this study, using hepatocellular carcinoma (HCC) as study model, we aimed explore effect mechanism reduced ferrous iron
Abstract With the rapid development of flexible optoelectronic devices, recyclability is highly desirable for alleviating resource waste and environmental pollution, but remains challenging. Here, a fully closed-loop recyclable crosslinked polyimide (RCPI) was fabricated via carboxyl ligand exchange between CPI with pendent groups cyclic Ti-oxo cluster (CTOC) labile ligands, which could be reconverted into reprocessable CTOC solution by pivalic acid. The RCPI-based embedded AgNWs@RCPI...
Sorafenib, a multitargeted kinase inhibitor, has been reported to elicit limited therapeutic effect in hepatocellular carcinoma (HCC). Currently, phototherapy, including photodynamic therapy (PDT) and photothermal (PTT), is emerging as powerful modality for cancer therapy. However, few studies have the effectiveness of combination sorafenib with PDT PTT HCC. Herein, we designed synthesized bovine serum albumin (BSA)-coated zinc phthalocyanine (ZnPc) (SFB) nanoparticle (ZnPc/SFB@BSA). The...
Poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) is a widely used hole transporting layer (HTL) in organic solar cells (OSCs), but its acidity severely reduces the stability of devices. Until now, very few HTLs were developed to replace PEDOT:PSS toward stable and high-performance OSCs. Herein, new cobalt-lanthanum (Co-La) inorganic system was reported as HTL show high conversion efficiency (PCE) 18.82 %, which among top PCEs binary Since electron-rich outer shell La atom...
Near-infrared electron acceptors for organic solar cells (OSCs) mostly contain electron-withdrawing 2-(3-oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile (IC) end groups, which can be modified by but limited to phenyl, thienyl, and naphthyl units with halogenated, methyl, methyloxy substitution. In this work, we employed an imide-containing unit construct a new IC group, based on series of were synthesized. The strong electron-deficient nature imide enables the show efficient intramolecular...
This paper proposes a simple yet effective approach to learn visual features online for improving loop-closure detection and place recognition, based on bag-of-words frameworks. The learns codeword in model from pair of matched two consecutive frames, such that the has temporally-derived perspective invariance camera motion. learning algorithm is efficient: binary descriptor generated mean image patch, mask learned discriminative projection by minimizing intra-class distances among feature...
Long non‑coding RNAs (lncRNAs) have been shown to contribute progression and prognosis of hepatocellular carcinoma (HCC). However, expression profiling interaction lncRNAs with messenger (mRNAs) microRNAs (miRNAs) remain largely unknown in HCC. The lncRNAs, mRNA miRNAs was obtained using microarray. Gene Ontology (GO) enrichment Kyoto Encyclopedia Genes Genomes pathway analysis were used characterize potential functions differentially expressed mRNAs. Cytoscape applied construct an...
Abstract Sorafenib (SOR), a multi‐kinase inhibitor for advanced hepatocellular carcinoma (HCC), reveals limited therapeutic effect due to lack of selectivity and evident drug resistance. In the present study, bismuth‐based mesoporous nanomaterial (NBOF) is loaded with SOR then coated polyethylene glycol folic acid conjugates (P‐FA) form an NBOF@SOR‐P‐FA nanocarrier system. The system achieves significantly enhanced anti‐cancer efficacy by combining chemotherapy radiotherapy. To evaluate...
Although sorafenib, a multi-kinase inhibitor, has provided noteworthy benefits in patients with hepatocellular carcinoma (HCC), the inevitable side effects, narrow therapeutic window, and low bioavailability seriously affect its clinical application. To be clinically distinctive, innovative drugs must meet needs of reaching tumor tissues cause limited effects to normal organs tissues. Recently, photodynamic therapy, utilizing combination photosensitizer light irradiation, was selectively...
Indoor photovoltaic is one of the most important applications organic solar cells (OSCs). As different from AM1.5G sunlight with broad spectra visible to near‐infrared region, indoor light are usually located in region. Therefore, a special material design for photoactive layer meet requirement required application photovoltaics. Herein, wide‐bandgap double‐cable conjugated polymer intentionally selected, which has well‐matched absorption use OSCs. This used as single OSCs, providing high...
Ferroptosis is identified as a novel type of cell death with distinct properties involved in physical conditions and various diseases, including cancers. It considered that ferroptosis provides promising therapeutic strategy for optimizing oncotherapy. Although erastin an effective trigger, the potential its clinical application largely restricted by poor water solubility concomitant limitations. To address this issue, innovative nanoplatform (PE@PTGA) integrated protoporphyrin IX (PpIX)...
Upregulated ubiquitin-conjugating enzyme E2M (UBE2M) is associated with poor prognosis in malignancies;However, the phenotype and mechanism of action UBE2M hepatocellular carcinoma (HCC) remain elusive.Here, we report that overexpressed correlated HCC patients.The level an independent prognostic factor for patients.UBE2M knockdown inhibits cell proliferation, migration, invasion, whereas its overexpression has opposite effect.Mechanistically, upregulated exerts oncogenic effects by...
Hepatocellular carcinoma (HCC) accounts for the predominant form of liver malignancy and presents a leading cause cancer-related death globally. Sorafenib (SOR), first-line targeted drug advanced HCC treatment, has battery untoward side effects. Photothermal therapy (PTT) been utilized as an effective adjuvant in synergy with other approaches. However, little is known about tumoricidal efficacy combining SOR PTT HCC. Herein, novel versatile nanoparticle, Cu2-xSe@SOR@PEG (CSP), that based on...