A5043433533- Cardiac Fibrosis and Remodeling
- Cardiovascular Function and Risk Factors
- Cardiac Ischemia and Reperfusion
- Cardiomyopathy and Myosin Studies
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Adipose Tissue and Metabolism
- Cardiac electrophysiology and arrhythmias
- Circular RNAs in diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Signaling Pathways in Disease
- Receptor Mechanisms and Signaling
- Heat shock proteins research
- Renin-Angiotensin System Studies
- Advanced Glycation End Products research
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Cardiac Valve Diseases and Treatments
- Tissue Engineering and Regenerative Medicine
- Cardiac Arrest and Resuscitation
- Cancer, Hypoxia, and Metabolism
- Endoplasmic Reticulum Stress and Disease
Fudan University
2015-2024
The First Affiliated Hospital, Sun Yat-sen University
2015-2024
Zhongshan Hospital
2015-2024
Sun Yat-sen University
2015-2024
Punan Hospital
2024
Zhongshan Hospital of Xiamen University
2024
Shanghai Institute of Hematology
2019-2024
Huashan Hospital
2023-2024
National Health and Family Planning Commission
2024
Zhejiang University
2013-2023
Background: Inflammation resolution and cardiac repair initiation after myocardial infarction (MI) require timely activation of reparative signals. Histone lactylation confers macrophage homeostatic gene expression signatures via transcriptional regulation. However, the role histone in response post-MI remains unclear. We aimed to investigate whether induces monocytes early remotely post-MI. Methods: Single-cell transcriptome data indicated that genes were activated bone marrow circulating...
Myocardial infarction (MI) is a major cause of death worldwide. Although percutaneous coronary intervention and artery bypass grafting can prolong life, cardiac damage persists. In particular, cardiomyocytes have no regenerative capacity. Mesenchymal stem cells (MSCs) are attractive candidates for the treatment MI. The manner by which MSCs exert beneficial effect upon injured source continued study.After isolation identification exosomes from MSCs, expression miR-210 was determined...
Rationale: Excessive myocardial fibrosis is the main pathological process in development of cardiac remodeling and heart failure; therefore, it important to prevent excessive fibrosis. We determined that microRNA-378 (miR-378) cardiac-enriched highly repressed during remodeling. therefore proposed miR-378 has a critical role regulation fibrosis, examined effects on after mechanical stress. Methods: Mechanical stress was respectively imposed mice through transverse aortic constriction (TAC)...
Rationale: Targeting inflammation has been shown to provide clinical benefit in the field of cardiovascular diseases. Although manipulating regulatory T-cell function is an important goal immunotherapy, molecules that mediate their suppressive activity remain largely unknown. IL (interleukin)-35, immunosuppressive cytokine mainly produced by T cells, a novel member IL-12 family and composed EBI3 (Epstein-Barr virus–induced gene 3) subunit p35 subunit. However, role IL-35 infarct healing...
Background Emerging evidence indicates that impaired angiogenesis may contribute to hypertension‐induced cardiac remodeling. The nicotinamide adenine dinucleotide–dependent deacetylase Sirtuin 3 ( SIRT 3) has the potential modulate angiogenesis, but this not been confirmed. As such, aim of study was examine relationship between 3‐mediated and Methods Results Our experiments were performed on knockout age‐matched wild‐type mice infused with angiotensin II (1400 ng/kg per minute) or saline for...
Mechanical overload can be classified into pressure and volume overload, causing concentric eccentric cardiac hypertrophy, respectively. Here, we aimed to differentiate the load-mediated signaling pathways involved in versus hypertrophy. Pressure or was imposed on C57BL/6J mice by transverse aortic constriction (TAC) regurgitation (AR), After surgery (2 wk), left ventricular structure function were evaluated echocardiographic, hemodynamic, histological analyses. Signaling related fibrosis,...
Doxorubicin (DOX) is a highly potent chemotherapeutic agent, but its usage limited by dose-dependent cardiotoxicity. DOX-induced cardiotoxicity involves increased oxidative stress and activated endoplasmic reticulum-mediated apoptosis. Alginate oligosaccharide (AOS) non-immunogenic, non-toxic biodegradable polymer, with anti-oxidative, anti-inflammatory anti-endoplasmic reticulum properties. The present study examined whether AOS pretreatment could protect against acute DOX cardiotoxicity,...
Systemic treatments are listed as first-line therapies for HCC with portal vein tumor thrombus (PVTT), resulting in modest efficacy. We aimed to evaluate the efficacy and safety of sintilimab plus bevacizumab combined radiotherapy PVTT identify prognostic biomarkers.
Objective. Anesthesia provides sedation and immobility, facilitating echocardiography in mice, but it influences cardiovascular function therefore outcomes of measurement. This study aimed to determine the effect optimal heart rate (HR) anesthetic timing on echocardiographic reproducibility under isoflurane anesthesia. Methods. Male C57BL/6J mice underwent high-resolution with relative fixed HRs timing. The same experiment was repeated once again after 1 week. Results. Echocardiography...
Background: Myocardial infarction is one of the leading causes morbidity and mortality worldwide, triggering irreversible myocardial cell damage heart failure. The role low-density lipoprotein receptor-related proteins 5 6 (LRP5/6) as coreceptors Wnt/β-catenin pathway in adult remain unknown. Insulin-like growth factor binding protein 4 dickkopf-related 1 (Dkk1) are 2 secreted LRP5/6 that play a crucial development through preventing activation. However, their roles unexplored. Methods: To...
Although inhibition of cyclic nucleotide phosphodiesterase type 3 (PDE3) has been reported to protect rodent heart against ischemia/reperfusion (I/R) injury, neither the specific PDE3 isoform involved nor underlying mechanisms have identified. Targeted disruption subfamily B (PDE3B), but not A (PDE3A), protected mouse from I/R injury in vivo and vitro, with reduced infarct size improved cardiac function. The cardioprotective effect PDE3B(-/-) was reversed by blocking cAMP-dependent PKA...
Abstract Alpha-lipoic acid (α-LA), a well-known antioxidant, was proved to active ALDH2 in nitrate tolerance and diabetic animal model. However, the therapeutic advantage of α-LA for heart failure related signaling pathway have not been explored. This study designed examine role α-LA–ALDH2 injury mitochondrial damage. knockout (ALDH2 −/− ) mice primary neonatal rat cardiomyocytes (NRCMs) were subjected assessment myocardial function autophagy. Our data demonstrated significantly reduced...
Sirtuin 5 (SIRT5) is a member of the NAD+-dependent sirtuin family protein deacylase that catalyzes removal post-translational modifications, such as succinylation, malonylation, and glutarylation on lysine residues. In light SIRT5's roles in regulating mitochondrion function, we show here SIRT5 deficiency leads to suppression mitochondrial NADH oxidation inhibition ATP synthase activity. As result, decreases production, increases AMP/ATP ratio, subsequently activates AMP-activated kinase...
Abstract Myocardial ischemia/reperfusion injury (MI/RI) is identified as a severe vascular emergency, and the treatment strategy of MI/RI still needs further improvement. The present study aimed to investigate potential effects mild therapeutic hypothermia (MTH) on underlying mechanisms. In (I/R) rats, MTH significantly improved myocardial injury, attenuated infarction, inhibited mitochondrial apoptosis pathway. results proteomics SLC25A10 main target treatment. Consistently, expressions in...
RNA-binding proteins play multiple roles in several biological processes. However, the of RBM15—an important protein and a significant regulator RNA methylation—in cardiovascular diseases remain elusive. This study aimed to investigate function RBM15 its fundamental mechanisms myocardial infarction (MI). Methylated immunoprecipitation sequencing was used explore N6-methyladenosine (m6A) difference between MI normal tissues. Our findings showed elevated level m6A MI, transcription profile...
Interleukin (IL)-5 is thought to play an important role in asthmatic bronchial mucosal inflammation and a potential therapeutic target. To investigate the effect of IL-5 on infiltration eosinophils airway vivo, we compared eosinophil counts their activation status airways without after topical instillation recombinant human IL-5. Eight subjects with mild atopic asthma underwent initial bronchoscopy during which control bronchoalveolar lavage (BAL) fluid as well mucosa were obtained, at same...
Qiliqiangxin (QL), a traditional Chinese medicine, has been used in the treatment of chronic heart failure. However, whether QL can benefit cardiac remodeling hypertensive state is unknown. We here examined effects on development hypertrophy through comparing those losartan C57BL/6 mice underlying transverse aorta constriction for 4 weeks. and were administrated at 0.6 mg 13.4 mg·kg·d, respectively. Cardiac hypertrophy, function, evaluated by echocardiography, catheterization, histology,...