A5003736471- Lipid metabolism and disorders
- Liver Disease Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Tryptophan and brain disorders
- Ginseng Biological Effects and Applications
- Autophagy in Disease and Therapy
- Metabolomics and Mass Spectrometry Studies
- Adipose Tissue and Metabolism
- Inflammasome and immune disorders
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Diet and metabolism studies
- Signaling Pathways in Disease
- Cardiac Fibrosis and Remodeling
- Nitric Oxide and Endothelin Effects
- Stress Responses and Cortisol
- Eicosanoids and Hypertension Pharmacology
- Cancer-related molecular mechanisms research
- Epigenetics and DNA Methylation
- Heart Rate Variability and Autonomic Control
- Hedgehog Signaling Pathway Studies
- Cardiac Ischemia and Reperfusion
- Adipokines, Inflammation, and Metabolic Diseases
State Administration of Traditional Chinese Medicine of the People's Republic of China
2017-2025
Hebei Medical University
2007-2025
Nanchang University
2025
First Affiliated Hospital of Nanchang University
2025
National Clinical Research Center for Digestive Diseases
2025
Jianghan University
2025
Songjiang District Central Hospital
2022-2025
Nanjing University of Chinese Medicine
2021-2024
I-Shou University
2023
E-Da Hospital
2023
Bazi Bushen (BZBS), a traditional Chinese medicine, has been proven effective in the treatment of age-related disease mouse models. However, whether its therapeutic effects are due to antiaging mechanism not yet explored. In present study, we investigated BZBS naturally aging mice by using behavioral tests, liver DNA methylome sequencing, methylation age estimation, and frailty index assessment. The analysis revealed decrease mCpG levels aged liver. tended restore age-associated decline...
Purpose The senescence-accelerated prone mouse 8 (SAMP8) is a widely used model for accelerating aging, especially in central aging. Mounting evidence indicates that the microbiota-gut-brain axis may be involved pathogenesis and progression of aging-related diseases. This study aims to investigate whether Bazi Bushen capsule (BZBS) attenuates deterioration intestinal function aging animal model. Methods In our study, SAMP8 mice were randomly divided into group, BZ-low group (0.5 g/kg/d...
Objective: Oridonin (Ori) is a diterpene compound that has multiple biological properties. Here, our study was conducted to observe the therapeutic effect of Ori on depression as well uncover mechanism. Methods: Lipopolysaccharide (LPS)-induced models were established both in C57BL/6 mice and primary astrocytes, which treated with Ori, autophagy agonist Rapamycin (Rap) inhibitor 3-Methyladenine (3-MA). The depressive-like behaviors assessed behavioral tests. Autophagy evaluated hippocampus...
A novel metabonomic method based on fast liquid chromatography coupled with ion trap-time of flight mass spectrometry (UFLC/MS-IT-TOF) was applied to study the metabolic changes plasma and urine in depression excess fatigue rats. Principal component analysis (PCA) partial least squares-discriminant (PLS-DA) were for classifying depression, control Metabolites which important classification three groups rats selected as potential biomarkers identified by MSn information achieved from...
Qiliqiangxin (QL), a traditional Chinese medicine, has been used in the treatment of chronic heart failure. However, whether QL can benefit cardiac remodeling hypertensive state is unknown. We here examined effects on development hypertrophy through comparing those losartan C57BL/6 mice underlying transverse aorta constriction for 4 weeks. and were administrated at 0.6 mg 13.4 mg·kg·d, respectively. Cardiac hypertrophy, function, evaluated by echocardiography, catheterization, histology,...
Qiliqiangxin capsule (QL) was developed under the guidance of TCM theory collateral disease and had been shown to be effective safe for treatment heart failure. The present study explored role mechanism by which herbal compounds QL act on energy metabolism, in vivo, pressure overload SD rats received ascending aorta constriction (TAC) establish a model myocardial hypertrophy. animals were treated orally period six weeks. significantly inhibited cardiac hypertrophy due aortic improved...
Background/Aims: Finite nucleos(t)ide analog (NA) therapy has been proposed as an alternative treatment strategy for chronic hepatitis B (CHB), but biomarkers post-treatment monitoring are limited. We investigated whether measuring core-related antigen (HBcrAg) after NA cessation may stratify the risk of subsequent clinical relapse (CR).Methods: This retrospective multicenter analysis enrolled adults with CHB who were prospectively monitored discontinuing entecavir or tenofovir negative...
Polysaccharide from fuzi (FPS), a Chinese herbal medicine extract, has been demonstrated to exert lipid lowering affects. In this study we examined potential mechanisms underlying affect, specifically alterations in expression of the LDL-receptor (LDL-R), 3-hydroxy-3-methyl glutaryl (HMG)-CoA reductase and cytochrome P450 7alpha-1 (CYP7alpha-1), using rat model hypercholesterolemia.
Context Bazi Bushen capsule (BZBS) has anti-ageing properties and is effective in enhancing memory.Objective To find evidence supporting the mechanisms biomarkers by which BZBS functions.Materials methods Male C57BL/6J mice were randomly divided into five groups: normal, ageing, β-nicotinamide mononucleotide (NMN), low-dose (LD-BZ) high-dose (HD-BZ). The last four groups subcutaneously injected with d-galactose (d-gal, 100 mg/kg/d) to induce ageing process. At same time, LD-BZ, HD-BZ NMN...
Abstract Background Chronic inflammation and metabolic dysfunction are key features of systemic aging, closely associated with the development progression age-related diseases. Bazi Bushen (BZBS), a traditional Chinese medicine used to alleviate frailty, delays biological aging by modulating DNA methylation levels. However, precise mechanism its anti-aging effect remains unclear. In this study, we developed Energy Expenditure Aging Index (EEAI) estimate age. By integrating EEAI transcriptome...
Considering the uncertain relationship between high-density lipoprotein cholesterol (HDL-C) and uric acid (UA) with diabetic retinopathy (DR),this study investigates link Uric Acid to High-Density Lipoprotein Cholesterol (UHR) DR in T2DM patients, evaluating its potential for diagnosis early prediction. This retrospective analyzed 1450 type 2 diabetes divided into NDR groups by retinal exams. We gathered demographic clinical data, calculated UHR, explored correlation development. Individuals...
Objectives: Limited studies have investigated the association between compliance with a Mediterranean diet and depression in China. We sought to explore potential adherence an alternate score (aMED) risk of developing among adults Eastern Methods: This study used prospective cohort design that involved total 52,232 individuals Shanghai Suburban Adult Cohort Biobank (SSACB). A reliable food frequency questionnaire (FFQ) was utilized evaluate dietary intake, we calculated aMED for each...
Lung cancer is one of the malignant cancers with highest incidence rate, and it important to identify factors contributing lung carcinogenesis for prevention. Lifestyle genetic play roles in development, however impact dietary factors, such as soy product intake, on risk remains inadequately understood. This study aims explore associations between risk, incidence, validate consistent effects intake European populations, thereby providing new insights Utilizing Shanghai Suburban Adult Cohort...
Activation of brown adipose tissue (BAT) thermogenesis could contribute to energy expenditure, which is critical for the treatment obesity and type 2 diabetes mellitus (T2DM). In present study, we aimed systematically investigate whether traditional Chinese medication Jinlida (JLD) granules improve metabolic disorders activate BAT in C57BL/6 J mice fed with a high-fat diet (HFD).In JLD (3.8 g/kg) 0.5% carboxymethyl cellulose (CMC) solution was administrated daily by oral gavage HFD-induced...
Background: Dyslipidemia is one of the mechanisms atherosclerosis (AS). Depletion estrogen plays a key role in pathogenesis postmenopausal AS women, and blood lipid levels women are closely related to endogenous levels. Phytoestrogens (PEs) exert estrogenic effects, including protection against AS, without adverse effects administration. Bazi Bushen capsule (BZBS) traditional Chinese medicine herbal compound prescription that has been shown contain 11 unique PEs. In present study, we...