A5100633554- Viral Infections and Vectors
- Gold and Silver Nanoparticles Synthesis and Applications
- Congenital Diaphragmatic Hernia Studies
- Neonatal Respiratory Health Research
- Lipid metabolism and biosynthesis
- Advanced Nanomaterials in Catalysis
- Tissue Engineering and Regenerative Medicine
- Neuroinflammation and Neurodegeneration Mechanisms
- Electrospun Nanofibers in Biomedical Applications
- Mitochondrial Function and Pathology
- Autophagy in Disease and Therapy
- interferon and immune responses
- Ubiquitin and proteasome pathways
- Peroxisome Proliferator-Activated Receptors
- Cellular transport and secretion
- Trace Elements in Health
- Silk-based biomaterials and applications
- Extracellular vesicles in disease
- Innovative Microfluidic and Catalytic Techniques Innovation
- Plasmonic and Surface Plasmon Research
- Molecular Sensors and Ion Detection
- Colorectal Cancer Treatments and Studies
- Bone Metabolism and Diseases
- Histone Deacetylase Inhibitors Research
- Telomeres, Telomerase, and Senescence
Zhejiang University
2021-2025
Hebei Medical University
2025
Lawrence Technological University
2019-2024
Shanghai Jiao Tong University
2022-2024
Second Affiliated Hospital of Zhejiang University
2024
Yangzhou University
2023-2024
Jiangnan University
2024
Harbin Medical University
2024
Second Affiliated Hospital of Harbin Medical University
2024
Soochow University
2023
Aim: Exosomes are nanoscale membranous vesicles secreted by most cell types able to transfer bioactive molecules among cells, which play crucial roles in intercellular communication. We characterized the exosomes derived from Toxoplasma gondii and detected immune response macrophages. Methods: used transmission electron microscopy, nanotracking analysis western blotting identify T. exosomes. Functional experiments were performed RAW264.7 cells for induction of cytokines, MAPKs (p38 MAPK, ERK...
A single fluorescent probe (SF-probe) that can simultaneously and discriminatively visualize two organelles is a powerful tool to investigate their interaction in cellular processes. However, it still challenging develop this unique type of due the lack feasible design strategy. Herein, we proposed dual-targeting group strategy construct SF-probes by integrating different organelle-targeting groups into same fluorophore. versatile fluorophore nonintrusive are elements In view only few having...
Backgroud Bronchopulmonary dysplasia (BPD) is one of the most important complications plaguing neonates and can lead to a variety sequelae. ability HIF-1α/VEGF signaling pathway promote angiogenesis has an role in neonatal lung development.
The absence of HIBCH or ECHS1, two Leigh syndrome genes, in cultured cells results abnormal mitochondrial morphology and respiratory defects. Fly eyes lacking either protein exhibit age-dependent degeneration. Elevated lysine methacrylation (Kmea) is observed both HIBCH- ECHS1-deficient fly tissues. Quantitative mass spectrometry reveals that many proteins are ectopically modified by Kmea these cells. Mimicking like CH60, FKBP4, BIP, LDHB, DHRS2 replicates the changes seen Reducing...
Gold nanorods (AuNRs) show great potential for versatile biomedical applications, such as stem cell therapy and bone tissue engineering. However, an indispensable shape-directing agent the growth of AuNRs, cetyltrimethylammonium bromide (CTAB) is not optimal biological studies because it forms a cytotoxic bilayer on AuNR surface, which interferes with interactions cells.Citrate-stabilized AuNRs various aspect-ratios (Cit-NRI, Cit-NRII, Cit-NRIII) were prepared by combination end-selective...
The regulation of lipid homeostasis is not well understood. Using forward genetic screening, we demonstrate that the loss dTBC1D22, an essential gene encodes a Tre2-Bub2-Cdc16 (TBC) domain-containing protein, results in droplet accumulation multiple tissues. We observe dTBC1D22 interacts with Rab40 and exhibits GTPase activating protein (GAP) activity. Overexpression either GTP- or GDP-binding-mimic form accumulation. mutant flies are defective mobilization. depletion induced by...
High TRABD expression is associated with tau pathology in patients Alzheimer's disease; however, the function of unknown. Human encodes a mitochondrial outer-membrane protein. The loss resulted fragmentation, and overexpression led to clustering fusion. C-terminal tail anchored outer membrane TraB domain could form homocomplexes. Additionally, forms complexes MFN2, MIGA2, PLD6 facilitate Flies lacking dTRABD are viable have normal lifespans. However, aging flies exhibit reduced climbing...
Abstract Background Bronchopulmonary dysplasia is a serious and lifelong pulmonary disease in premature neonates that influences around one-quarter of newborns. The wingless-related integration site /β-catenin signaling pathway, which abnormally activated the lungs with fibrosis, affects cell differentiation lung development. Methods Newborn rats were subjected to hyperoxia exposure. Histopathological changes evaluated through immunohistochemistry, activation disheveled Wnt pathway...
Vitamin D is a lipid soluble vitamin that mostly used to treat bone metabolism-related diseases. In this study, the effect of Cd toxicity in vitro on osteogenic differentiation derived from BMSCs and alleviating lα, 25-(OH)2D3 were investigated. Cell index real time was monitored using Real-time cell analyzer (RTCA) system. The activity alkaline phosphatase (ALP), calcified nodules distribution Runx2 protein detected ALP staining, alizarin red immunofluorescence, respectively. Furthermore,...
Stimulator of the interferon gene (STING) is involved in mammalian antiviral innate immunity as an (IFN) activator. However, there still a lack clarity regarding molecular characterization goose STING (GoSTING) and its role immune response. In present study, we cloned GoSTING performed series bioinformatics analyses. was grouped into avian clades showed highest sequence similarity to duck STING. The vitro experiments that mRNA levels GoSTING, IFNs, IFN-stimulated genes (ISGs),...
Abstract Photo‐mediated synthesis wielding localized surface plasmon resonance (LSPR) of nanoscale metal is widely applied to sculpt silver (Ag) nanocrystals with controllable dimensions and morphologies. However, this photo‐mediated strategy remains underutilized owing low efficiency inferior quality in conventional batch reactors. Here, the effective Ag demonstrated via flow reactors elucidates anisotropic growth mechanism. The investigation reveals that intersection between excitation...
Osteocyte senescence is associated with skeletal dysfunction, but how to prevent bone loss and find the effective therapeutic targets a potential scientific concern. Cadmium (Cd) widespread environmental contaminant that causes substantial damage in both animals humans. Oligomeric proanthocyanidins (OPC) are naturally polyphenolic substances found various plants demonstrate significant anti-senescence potential. Here, we investigated protective effects of OPC against Cd-induced osteocytes...
Lipid homeostasis is essential to cells. However, its regulation not well understood. Using forward genetic screen, we demonstrated that the loss of CG5745, an gene in Drosophila encodes a Tre2–Bub2–Cdc16 (TBC) domain-containing protein, results lipid droplet accumulation multiple tissues. We named this as dTBC1D22 based on homology with mammalian genes TBC1D22A and TBC1D22B. The TBC proteins are potential Rab GTPase activating (GAPs). observed GAP activity was critical for function...
Abstract Background: Bronchopulmonary dysplasia (BPD) is a serious and lifelong pulmonary disease in premature neonates, which has an influence on quarter of newborns. Wingless/integrated(Wnt)/β-catenin signaling pathway affects lung cell differentiation tissue structure, abnormal activation the lungs rats with fibrosis. Method: Newborn were subjected to hyperoxia-exposure, histopathological changes tissues evaluated through Immunohistochemistry (IHC), Dishevelled (DVL-1) pathways detected...