A5064121512- Bone Tissue Engineering Materials
- Foot and Ankle Surgery
- Silk-based biomaterials and applications
- Pregnancy-related medical research
- Pelvic and Acetabular Injuries
- Hip and Femur Fractures
- Spine and Intervertebral Disc Pathology
- Osteoarthritis Treatment and Mechanisms
- Polymer crystallization and properties
- Polymer Nanocomposites and Properties
- Tendon Structure and Treatment
- biodegradable polymer synthesis and properties
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Advanced Polymer Synthesis and Characterization
- User Authentication and Security Systems
- Curcumin's Biomedical Applications
- Atherosclerosis and Cardiovascular Diseases
- Collagen: Extraction and Characterization
- Advanced Authentication Protocols Security
- Cryptography and Data Security
- Diabetic Foot Ulcer Assessment and Management
- Sports injuries and prevention
- Electrochemical sensors and biosensors
- Calcium Carbonate Crystallization and Inhibition
Beihang University
2025
Capital Medical University
2021-2025
Beijing Tongren Hospital
2021-2025
Henan University
2025
Fudan University
2011-2024
Zhongshan Hospital
2016-2023
Institute of Zoology
2022-2023
Chinese Academy of Sciences
2022-2023
Lanzhou University
2003-2022
The First Affiliated Hospital, Sun Yat-sen University
2016-2022
Abstract Intra‐articular injection of drugs is an effective strategy for osteoarthritis (OA) treatment. However, the complex microenvironment and limited joint space result in rapid clearance drugs. Herein, a nanogel‐based proposed prolonged drug delivery remodeling. Nanogel constructed through functionalization hyaluronic acid (HA) by amide reaction on surface Kartogenin (KGN)‐loaded zeolitic imidazolate framework‐8 (denoted as KZIF@HA). Leveraging inherent hydrophilicity HA, KZIF@HA...
Abstract Recently, strong polymer‐based hydrogels have been intensively investigated. However, the development of tough protein with controlled degradation for bone regeneration has rarely reported. Here, regenerated silk fibroin/gelatin (RSF/G) both strength and are prepared via physically chemically double‐crosslinked networks. As a representative example, 9%RSF/3%G hydrogel shows approximately 80% elongation compressive tensile modulus up to 0.25 0.21 MPa, respectively. It also rate that...
Abstract Cartilage equivalents from hydrogels containing chondrocytes exhibit excellent potential in hyaline cartilage regeneration, yet current approaches have limited success at reconstituting the architecture to culture nondifferentiated vitro. In this study, specially designed lacunar hyaluronic acid microcarriers (LHAMCs) with mechanotransductive conditions that rapidly form stable (HA) N ‐hydroxy succinimide ester (NHS‐ester) are reported. Specifically, carboxyl‐functionalized HA is...
Abstract Efferocytosis, an intrinsic regulatory mechanism to eliminate apoptotic cells, will be suppressed due the delayed apoptosis process in aging‐related diseases, such as osteoarthritis (OA). In this study, cartilage lesion‐localized hydrogel microspheres are developed remodel situ efferocytosis reverse senescence and recruit endogenous stem cells accelerate repair. Specifically, aldehyde‐ methacrylic anhydride (MA)‐modified hyaluronic acid (AHM), loaded with pro‐apoptotic liposomes...
Self-assembly of amphiphilic block copolymers into well-defined nanostructures as drug delivery systems for the treatment cancer has been a hot subject research. However, sequential polymerizations synthesized with covalent links suffered mainly from multistep synthesis and purification procedures well repeated optimization polymer composition to form aggregates structures. To overcome these drawbacks, supramolecular noncovalent were developed provide simplicity required. Herein, we designed...
Osteoarthritis (OA) is characterized by inflammation and extracellular matrix (ECM) degradation one of the most common chronic degenerative joint diseases that causes pain disability in adults. Urolithin A (UA) has been widely reported for its anti-inflammatory properties several diseases. However, effects UA on OA remain unclear. The aim current study was to investigate mechanism interleukin-1β (IL-1β)-induced chondrocytes.No marked cytotoxicity noted, protected cartilage from damage...
Manganese dioxide (MnO2) nanostructures have aroused great interest among analytical and biological medicine researchers as a unique type of tumor microenvironment (TME)-responsive nanomaterial. However, reliable approaches for synthesizing yolk–shell (YSNs) with mesoporous MnO2 shell still remain exciting challenges. Herein, YSN (size, ∼75 nm) containing Er3+-doped upconversion/downconversion nanoparticle (UCNP) core large cavity is demonstrated the first time. This nanostructure not only...
Recently, regenerated silk fibroin is one of the most investigated silk-based materials for tissue engineering. However, it needs complex preparation process and will irresistibly denature to solid state with time, which biggest challenge produce in large scale widely use as commercial material. In this work, industrially produced sericin, amino acid, powder were on its physico–chemical biological properties compared laboratory prepared fibroin, order excavate potential application...
Abstract Night shift workers with disordered rhythmic mechanical loading are more prone to intervertebral disc degeneration (IDD). Our results showed that circadian rhythm (CR) was dampened in degenerated and aged NP cells. Long-term environmental CR disruption promoted IDD rats. Excessive strain disrupted the inhibited expression of core clock proteins. The inhibitory effect on extracellular matrix genes could be reversed by BMAL1 overexpression Rho/ROCK pathway demonstrated mediate...
At the bend and bifurcation of arteries prone to atherosclerosis, pulsatile blood retention may cause overstretch on tube wall. It has been reported that more than half foam cells found in atherosclerotic plaques are derived from vascular smooth muscle (VSMCs), but mechanism is not adequately understood. In this work, we used a microfluidic device apply cyclic stretch (15 % 0.05 Hz) VSMC for 24 h. The caused significant increase intracellular lipid accumulation, accompanying with...
Lung cancer is one of the malignant cancers with highest incidence rate, and it important to identify factors contributing lung carcinogenesis for prevention. Lifestyle genetic play roles in development, however impact dietary factors, such as soy product intake, on risk remains inadequately understood. This study aims explore associations between risk, incidence, validate consistent effects intake European populations, thereby providing new insights Utilizing Shanghai Suburban Adult Cohort...
Abstract A stretchable electronic facial mask (SEFM) for skin electroporation by transdermal drug delivery is introduced. The SEFM exhibits characteristics of reusability, water‐resistant, low cost, and portability. To achieve these objectives while maintaining satisfactory mechanical electrical performance the device, two main areas are innovated: (1) Grinding doping modification conductive ink to enhance its adhesion silicone increase conductivity through material research, as well...
The root system architecture (RSA) determines plant growth and yield. characterization of optimal RSA discovery genetic loci or candidate genes that control traits are therefore important research goals. However, the hidden nature makes it difficult to perform nondestructive, rapid analyses RSA. In this study, we developed an automated, high-throughput phenotyping platform (Root-HTP) a corresponding data processing pipeline for efficient, large-scale wheat (Triticum aestivum L.) This is...
Bioprinting is an emerging approach for constructing sophisticated tissue analogues with detailed architectures such as vascular networks, which requires bioink to fulfill the highly printable property and provide a cell-friendly microenvironment mimicking native extracellular matrix (ECM). Here, we developed human placental ECM-derived (hp-bioink) meeting requirements of 3D printing printability bioactivity. We first decellularized placenta, followed by enzymatic digestion, dialysis,...
The morphology of foot joints is widely accepted as a significant factor in the development various disorders. Nevertheless, role first tarsometatarsal joint (TMT1) hallux valgus (HV) remains unclear, and its impact on TMT1 instability has not been fully explored. This study aimed to investigate potential correlation with HV instability.Weightbearing computed tomography (WBCT) scans 82 consecutive feet 79 controls were reviewed this case-control study. Three-dimensional (3D) models...