A5068426566- Atherosclerosis and Cardiovascular Diseases
- Protein Hydrolysis and Bioactive Peptides
- Coronary Interventions and Diagnostics
- Cardiac and Coronary Surgery Techniques
- Neonatal Respiratory Health Research
- Ferroptosis and cancer prognosis
- Cancer, Hypoxia, and Metabolism
- Neuropeptides and Animal Physiology
- 3D Printing in Biomedical Research
- Insect Utilization and Effects
- Hip and Femur Fractures
- Meat and Animal Product Quality
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer Cells and Metastasis
- Nitric Oxide and Endothelin Effects
- Microfluidic and Bio-sensing Technologies
- Sports injuries and prevention
- Trauma and Emergency Care Studies
- Cardiovascular Health and Disease Prevention
- Peptidase Inhibition and Analysis
University of Chinese Academy of Sciences
2021-2025
Chinese Academy of Sciences
2021-2023
South China Sea Institute Of Oceanology
2021
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2021
Institute of Oceanology
2021
At the bend and bifurcation of arteries prone to atherosclerosis, pulsatile blood retention may cause overstretch on tube wall. It has been reported that more than half foam cells found in atherosclerotic plaques are derived from vascular smooth muscle (VSMCs), but mechanism is not adequately understood. In this work, we used a microfluidic device apply cyclic stretch (15 % 0.05 Hz) VSMC for 24 h. The caused significant increase intracellular lipid accumulation, accompanying with...
The aim of this study was to discover potent angiotensin-converting enzyme (ACE) inhibitory (ACEI) peptides from Pinctada fucata (P. fucata) for treating hypertension and characterize them using in silico analysis. P. proteins were hydrolyzed by Alcalase®, a serine endopeptidase with broad selectivity, at various times (0, 2, 4, 6, 8, 10 h). degree hydrolysis (DH) ACEI activity the different hydrolysates measured. Considering molecular weight activity, h hydrolysate purified series...
Atherosclerosis is the narrowing of arteries due to formation fatty plaques, which main cause myocardial infarction and stroke. It important develop an in vitro model that can combine multiple-type cell co-culture, vessel wall-like structure, fluid condition simulate processes atherosclerosis. Herein, we used a simple microfluidic chip made three polydimethylsiloxane layers co-culture endothelial smooth muscle cells flat rectangular microchannel. After being connected with circulating...
Mechanical ventilation is an essential respiratory support in acute distress syndrome and other intensive care cases, but it also leads to ventilator-induced lung injury (VILI). In this work, we used a microfluidic device simulate vivo with cyclic stretch (30% total deformation 15 cycles per minute) oxygen (air) exchange driven by controlled pressured airflow. Basis on experimental setting, found that the stretching caused significant cell damage four types of cells, accompanied excessive...
In order to discover the dipeptidyl peptidase IV (DPP-IV) peptides quickly from Pinctada fucata (P. fucata), in this research, 20 reported DPP-IV inhibitors database were used form a training set and construct pharmacophore models, which then valuated by test molecules fisher random validation. The online website PeptideCutter was employed perform virtual hydrolysis with P. meat protein as raw materials. optimal model (Hypo1) initially screen 192 low-molecular (the number of amino acids no...