A5049482551- Marine Sponges and Natural Products
- Advanced biosensing and bioanalysis techniques
- Microbial Natural Products and Biosynthesis
- Biosensors and Analytical Detection
- RNA modifications and cancer
- Cell death mechanisms and regulation
- MicroRNA in disease regulation
- Higher Education and Teaching Methods
- Phonetics and Phonology Research
- Histone Deacetylase Inhibitors Research
- EFL/ESL Teaching and Learning
- Ubiquitin and proteasome pathways
- Protein Degradation and Inhibitors
- Coral and Marine Ecosystems Studies
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Education and Work Dynamics
- Electrochemical sensors and biosensors
- Nerve injury and regeneration
- Second Language Learning and Teaching
- Immune Response and Inflammation
- Prostate Cancer Treatment and Research
- Metabolomics and Mass Spectrometry Studies
- NF-κB Signaling Pathways
- Synthesis and Biological Activity
Nanjing Agricultural University
2022-2025
Shanxi Medical University
2014-2025
Ocean University of China
2022-2025
Taiyuan Central Hospital
2021-2025
Guizhou University
2025
Chinese PLA General Hospital
2018-2025
Hainan Normal University
2025
Tongji University
2015-2024
Second Military Medical University
2014-2024
Tongji Hospital
2010-2024
This study was designed to investigate the combined effects of ultrasound and mild heat on viability S. aureus in association with cell membrane integrity intracellular enzyme activity. Cells were treated by under 55°C for 3, 5, 7, 10, 15min. The dynamic changes viability, sublethal injury death evaluated using flow cytometric assay. Microscopies applied identify morphological appearance, ultrastructure topography aureus. results showed damage synchronous esterase inhibition during exposure...
Alveolar macrophage (AM) polarization plays a pivotal role in the inflammatory response during acute lung injury (ALI). As reported previously, vasodilator-stimulated phosphoprotein (VASP) may function as an anti-inflammatory agent hepatic tissues. However, specific of VASP ALI-induced remains unclear. To elucidate ALI, we established lipopolysaccharide (LPS)-induced M1 model MH-S cells. RNA sequencing was performed to identify differentially expressed genes polarization. The results...
miRNAs are involved in cancer development and progression, acting as tumor suppressors or oncogenes. In this study, miRNA profiling was conducted on 10 paired bladder tissues using 20 GeneChip Array, differentially expressed were identified adjacent noncancerous of any disease stage/grade. After being validated expanded cohort 67 human cell lines by quantitative real-time PCR (qRT-PCR), it found that miR-100 downregulated most significantly tissues. Ectopic restoration expression cells...
The self-calibration capability of ratiometric signals has been widely considered to enhance the accuracy, sensitivity, and anti-interference ability immunoassays. Exploring a new approach generate can provide more options for various requirements. Herein, we integrated negative-readout competitive positive-readout noncompetitive immunoassays into single assay by employing different color tracers, labeled peptidomimetic anti-immunocomplex peptides, create unconstrained signal approach. Using...
Castration-resistant prostate cancer (CRPC) and its treatment are challenging issues in management. Here, we report that miR-663 is upregulated CRPC tissues. Overexpression of LNCaP cells promotes cell proliferation invasion, neuroendocrine differentiation, reduction dihydrotestosterone-induced upregulation prostate-specific antigen expression. Furthermore, results situ hybridization show expression correlated with Gleason score TNM stage an independent prognostic predictor clinical...
Two new biscembranoid-like compounds, bissubvilides A (1) and B (2), were isolated together with sarsolilide (3), the proposed biogenetic precursor to 1, from soft coral Sarcophyton subviride. The structures absolute configurations solved by spectroscopic analysis TDDFT/ECD DFT/NMR calculations. represent a novel skeleton presumed derive cembrane-type diene capnosane-type dienophile via Diels–Alder reaction. These two molecules exerted no cytotoxicity against MG-63 or A549 tumor cells HuH7...
Abstract Olfactory ensheathing cells (OECs) are a unique type of macroglia with axonal growth‐promoting properties. The migrating ability OECs in CNS is essential for neural regeneration. However, little known about the extracellular and intracellular factors that regulate OEC migration. In present study, we examined effects glial cell line‐derived neurotrophic factor (GDNF) on Initially, “scratch” migration assay, Boyden chamber explant assay showed GDNF could promote vitro. Treatment also...
We have established a fluorometric and colorimetric detection method for alkaline phosphatase based on the difference in catalytic activity of polyphenol oxidase mimetic enzymes formed by nucleotide coordinated copper ion.
Circular RNA (CircRNA) is a newly identified special class of non-coding (ncRNA) that plays an important regulatory role in the progression certain diseases. Herein, our results indicate CircMEG3 downregulated expression and negatively correlated with telomerase-related gene Cbf5 human liver cancer. Moreover, inhibits growth cancer stem cells vivo vitro. m6A methyltransferase METTL3 dependent on HULC. Cbf5, component telomere synthetase H/ACA ribonucleoprotein (RNP; catalyst pseudouracil...
Alternarin A (1), a rearranged drimane meroterpenoid characterized by thioglycerate moiety, was isolated together with two known analogues from the coral-associated fungi Alternaria sp. ZH-15. Its structure determined based on spectroscopic analysis, modified Mosher's method, and TDDFT/ECD calculations. In primary cultured cortical neuronal network, compound 1 effectively inhibited activity of spontaneous synchronous Ca2+ oscillations 4-aminopyridine induced epileptic discharges in low...
Abstract Aging is an irreversible process. This research aims to study the anti-aging effects of GRCP, a compound preparation made by Ganoderma lucidum and Rhodiola rosen , in aging rats. Rats were subcutaneously injected with 400 mg/kg d -galactose daily, could be induced after 8 weeks. The rats treated GRCP. experiment was divided into 6 groups. randomly model group, positive control low-dose GRCP group (25 body weight), medium-dose (50 high-dose (100 healthy normal used as blank controls....