A5109172873- Marine Sponges and Natural Products
- Microbial Natural Products and Biosynthesis
- Traditional and Medicinal Uses of Annonaceae
- Plant chemical constituents analysis
- Synthesis and Biological Activity
- Genomics and Phylogenetic Studies
- Bioactive natural compounds
- Phytochemical compounds biological activities
- Synthesis of Indole Derivatives
- Phytochemistry and Biological Activities
- Microbial Community Ecology and Physiology
- Protein Hydrolysis and Bioactive Peptides
- Chemical synthesis and alkaloids
- Meat and Animal Product Quality
- Microbial Metabolism and Applications
- Sesquiterpenes and Asteraceae Studies
- Protist diversity and phylogeny
- Biological Activity of Diterpenoids and Biflavonoids
- Fungal Plant Pathogen Control
- Methane Hydrates and Related Phenomena
- Power Systems and Renewable Energy
- Atmospheric and Environmental Gas Dynamics
- Bioactive Compounds and Antitumor Agents
- Empathy and Medical Education
- Radiomics and Machine Learning in Medical Imaging
Hunan Normal University
2025
Hunan Provincial People's Hospital
2025
Institute of Oceanology
2006-2024
Chinese Academy of Sciences
2007-2024
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2021-2024
South China Sea Institute Of Oceanology
2007-2024
Sichuan University
2024
University of Chinese Academy of Sciences
2024
Objective To explore the current status of clinical nurses’ narrative medicine (NM) ability and its related influencing factors, so as to provide a theoretical basis for nursing managers develop targeted nurse training programmes. Design A cross-sectional study. Setting total 1792 nurses from eight medical institutions in Hunan province were selected participants using convenience sampling. Main outcome measures Online questionnaires employed collect general data, NM competence scores,...
For exploring structurally diverse metabolites and uniquely metabolic mechanisms, we systematically investigated the chemical constituents putative biosynthesis of Janibacter sp. SCSIO 52865 derived from deep-sea sediment based on OSMAC strategy, molecular networking tool, in combination with bioinformatic analysis. As a result, one new diketopiperazine (1), along seven known cyclodipeptides (2-8), trans-cinnamic acid (9), N-phenethylacetamide (10) five fatty acids (11-15), was isolated...
A marine bacterium, designated SCSIO 03483(T), was isolated from a sediment sample collected the Nansha Islands in South China Sea. The strain produced roundish colonies with diffusible yellow-coloured pigment on nutrient agar medium or 2216. Optimal growth occurred presence of 0-4 % (w/v) NaCl, at pH 7.0 and temperature range 28-37 °C. 16S rRNA gene sequence analysis indicated that isolate belonged to family Flavobacteriaceae showed relatively high similarity Imtechella halotolerans K1(T)...
Two new quinoldione alkaloids, methyl 2-(3-hydroxy-1-methyl-2,4-dioxo-1,2,3,4-tetrahydroquinolin-3-yl)acetate (1) and 3-hydroxy-1-methyl-3-(2-oxopropyl)quinoline-2,4(1H,3H)-dione (2), two quinolinone alkaloids previously synthesized but first isolated as natural products, N-methylflindersine (3) 4-hydroxy-3-methoxy-1-methyl-2(1H)-quinolinone (4), were from the stem bark of Micromelum falcatum, together with known N-methylswietenidine-B (5). Their structures established mainly on basis 1D-...
The aim of this study was to discover potent angiotensin-converting enzyme (ACE) inhibitory (ACEI) peptides from Pinctada fucata (P. fucata) for treating hypertension and characterize them using in silico analysis. P. proteins were hydrolyzed by Alcalase®, a serine endopeptidase with broad selectivity, at various times (0, 2, 4, 6, 8, 10 h). degree hydrolysis (DH) ACEI activity the different hydrolysates measured. Considering molecular weight activity, h hydrolysate purified series...
A new prenylated flavon-4-ol with a modified ring A, which we have named pongaflavanol (1), was isolated from the stem bark of Pongamia pinnata along known compound tunicatachalcone (2). The structure 1 elucidated on basis spectroscopic data.
Abstract Catunaregin ( 1 ) and epicatunaregin 2 ), two novel norneolignans with a unique O‐bridged furopyran ring, together three known neolignans, ficusal, balanophonin, 5″‐methoxy‐4″‐ O ‐(8‐guaiacylglycerol)buddlenol A, were isolated from the stem bark of Catunaregam spinosa , Chinese mangrove associate. Their structures elucidated by spectroscopic means, including two‐dimensional NMR techniques. Compounds exhibited moderate inhibition against mammary cancer F10 cell line.
Two new prenylated flavonoids (1, 2), together with five known compounds, were isolated from the stem bark of Pongamia pinnata. Their structures characterized on basis spectral data
A new flavanone, 4′,5,7-trihydroxy-6,8-di-(2-hydroxy-3-methylbut-3-enyl)- was isolated from the aerial parts of Derris trifoliate, together with eleven known compounds: rotenone, tephrosin, 12a-hydroxyrotenone, deguelin, 6a,12a-dehydro-rotenone, dehydrodeguelin, 7a-O-methyldeguelol, 7a-O-methylelliptonol, 5,7,3',4'-tetra-hydroxy-6,8-diprenylisoflavone, daidzein and 4'-hydroxy-7-methoxyflavanone. 7a-O-Methylelliptonol for first time genus Derris. Their structures were characterized on basis...
Two new coumarins, 7-methoxy-8-(2-hydroxmethyl-1-O-isovaleryl-4-butenyl)-coumarin (1) and 7-methoxy-8-(1-hydroxy-2-O-b-glucopyranosyl-3-methyl-4-butene-1-yl)coumarin (2), twelve known coumarins 3–14 were isolated from the stem bark of Micromelum falcatum. The structures compounds 1–14 elucidated by extensive spectroscopic data analyses. toxicity was tested using a brine shrimp assay in vitro antiproliferative against mammary cancer (F10) lung (HvEvc) cell lines MTT method. Some had moderate...
Marine methane sequestration pattern and potential play significant roles in climate change mitigation. It is essential to study the fate of bubbles migrating from seafloor, given widespread occurrence seeping seafloor. We investigated kinetics hydrate formation bubble flow, including mass transfer CH4 gas water molecules at different flow patterns, morphological evolution consumption during reactor, 277.2 K 12 MPa corresponding temperature pressure "Haima" cold surroundings. found that a...
Deep-sea sediment-derived bacterium may make full use of self-genes to produce more bioactive metabolites adapt extreme environment, resulting in the discovery novel with unique structures and metabolic mechanisms. In paper, we systematically investigated structurally diversity their biosynthesis from deep-sea Agrococcus sp. SCSIO 52902 based on OSMAC strategy, Molecular Networking tool, combination bioinformatic analysis. As a result, three new compounds one natural product, including...
An ethyl acetate extract of a marine actinomycete strain, Nocardiopsis mentallicus SCSIO 53858, isolated from deep-sea sediment sample in the South China Sea, exhibited anti-quorum-sensing (QS) activity against Chromobacterium violaceum CV026. Guided by anti-QS activity, novel active compound was and purified identified as 2,3-dimethoxycinnamic acid (2,3-DCA) through spectral data analysis. At concentration 150 μg/mL, 2,3-DCA robust inhibitory effects on three QS-regulated traits C. CV026:...
Marine actinomycetes, especially Streptomyces, are recognized as excellent producers of diverse and bioactive secondary metabolites on account the multiplicity marine habitations unique ecological conditions, which yet to be explored in terms taxonomy, ecology, functional activity. Isolation, culture genome analysis novel species Streptomyces explore their potential for discovering compounds is an important approach natural product research. A actinobacteria, designated strain SCSIO 75703 T,...
Abstract Four new coumarins, micromelosides A–D, together with four known coumarins were isolated from the stem bark of Micromelum falcatum . The complete assignments 1 H and 13 C NMR chemical shifts for these compounds achieved by means 1D 2D techniques, including H‐ COSY, HSQC, HMBC NOE difference. Copyright © 2009 John Wiley & Sons, Ltd.
Guided by the brine shrimp lethality assay, a new cyclitol derivative, sarcotride D (1), was isolated from marine sponge Sarcotragus species. The structure established based on NMR and MS analyses.
The effects of glycopeptides, prepared from pearl oyster Pinctada fucata, on embryonic development, larval and juvenile growth adult non-specific immunity P. fucata were investigated in this study. Glycopeptides had a pronounced stimulatory effect development fucata. enhancing with increased glycopeptide concentrations. All haemocytes, phagocytosis, aggregation, serum microbiostatic activity bacteriocidal all showed significant increases after 60-day feeding, relative to unfed controls....