A5020095413- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Esophageal Cancer Research and Treatment
- Gastric Cancer Management and Outcomes
- Esophageal and GI Pathology
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Helicobacter pylori-related gastroenterology studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastroesophageal reflux and treatments
- Liver Disease and Transplantation
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Diabetes Treatment and Management
- Lung Cancer Diagnosis and Treatment
- Gastrointestinal Bleeding Diagnosis and Treatment
- Tracheal and airway disorders
- Veterinary medicine and infectious diseases
- Cholangiocarcinoma and Gallbladder Cancer Studies
- HIV, Drug Use, Sexual Risk
- Head and Neck Cancer Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Systemic Lupus Erythematosus Research
I-Shou University
2016-2025
E-Da Hospital
2016-2025
Second Affiliated Hospital of Xi'an Jiaotong University
2024
Kaohsiung Medical University
2024
National Sun Yat-sen University
2024
Fu Jen Catholic University
2018
Tao Yuan General Hospital
1997-2010
There are limited data on antiviral treatment
ABSTRACT Background Alanine aminotransferase (ALT) frequently elevates in chronic hepatitis B patients stopping nucleos(t)ide analogs (NAs). Aims To clarify the association between ALT elevation and HBsAg seroclearance after NA withdrawal. Methods This multicenter cohort study reviewed consecutive discontinuing 2004/04/01 2022/05/24. Treatment initiation discontinuation generally followed Asian‐Pacific guidelines. Eligible had negative HBeAg undetectable HBV DNA before treatment cessation,...
There remains an unmet need for convenient biomarkers to assess the risks of discontinuing nucleos(t)ide analogues (NAs) in chronic hepatitis B (CHB).To investigate if core-related antigen (HBcrAg) is independent surface (HBsAg) risk prediction NA cessation.This prospective multicentre study enrolled 135 CHB patients who stopped entecavir or tenofovir after achieving viral remission a median 25.2 months. All with negative HBeAg and undetectable DNA, were then observed clinical relapse HBsAg...
Background: Although cold snare polypectomy (CSP) is considered effective in reducing delayed postpolypectomy bleeding risk, direct evidence supporting its safety the general population remains lacking. Objective: To clarify whether CSP would reduce risk after compared with hot (HSP) population. Design: Multicenter randomized controlled study. (ClinicalTrials.gov: NCT03373136) Setting: 6 sites Taiwan, July 2018 through 2020. Participants: Participants aged 40 years or older polyps of 4 to 10...
Objective The Taiwan Government issued a policy to restrict antimicrobial usage since 2001. We aimed assess the changes in antibiotic consumption and primary resistance of H. pylori after this impact virulence factors on resistance. Methods defined daily dose (DDD) antibiotics was analyzed using National Health Insurance (NHI) research database. strains isolated from treatment naïve (N=1395) failure prior eradication therapies (N=360) 9 hospitals between 2000 2012 were used for analysis....
<h3>Objective</h3> Significant heterogeneity was observed in previous trials that assessed the efficacies of sequential therapy for 10 days (S10) versus triple 14 (T14) first-line treatment <i>Helicobacter pylori.</i> We aimed to compare efficacy S10 and T14 assess factors affecting their efficacies. <h3>Design</h3> conducted this open-label randomised multicentre trial eight hospitals one community Taiwan. 1300 adult subjects with <i>H pylori</i> infection naïve were (1:1) receive...
Summary Background Finite nucleos(t)ide analogue (NUC) therapy has been proposed as an alternative treatment strategy for chronic hepatitis B (CHB). Aim To quantify the incidence of severe flares following NUC cessation in everyday clinical practice. Methods This population‐based cohort study enrolled 10,192 patients (male 71.7%, median age 50.9 years, cirrhosis 10.7%) who had received first‐line NUCs at least 1 year before discontinuing treatment. The primary outcome was flare with hepatic...
Risk factors for mortality in acute variceal hemorrhage remain incompletely understood. Whether endoscopy timing is associated with risk of has not been investigated. We aimed to investigate in-hospital cirrhotic patients hemorrhage, emphasis on timing.Three hundred and eleven (73% male 23% female) consecutive presenting from July 2004 2007 were The univariate association as the predictor was examined. Independent determined by multivariate logistic regression analysis consisting clinical,...
Summary Background Racial and ethnic disparities exist for hepatitis C virus (HCV) treatment hepatocellular carcinoma (HCC) survival. Aim To evaluate the impact of HCV on such disparities. Methods In a retrospective cohort study, we analysed 6069 patients with HCV‐related HCC (54.2% Asian, 30.1% White, 8.5% Black, 7.3% Hispanic) from centres in United States Asia. Results The mean age was 61, 60, 59 68, respectively, Hispanic Asian patients. Black were most likely to have Barcelona Clinic...
INTRODUCTION: Concerns regarding bleeding remain in cold snare polypectomy (CSP) for small pedunculated (0-Ip) polyps. The aim of this study was to compare the risk CSP and hot (HSP) such lesions. METHODS: Data on 0-Ip colorectal polyps ≤10 mm were extracted from a large, pragmatic, randomized trial. Immediate postpolypectomy (IPPB), defined as perioperative use clip bleeding, evaluated through polyp-level analysis. Delayed (DPPB), occurring within 2 weeks postoperatively, assessed at...
Background/Aims: Finite nucleos(t)ide analog (NA) therapy has been proposed as an alternative treatment strategy for chronic hepatitis B (CHB), but biomarkers post-treatment monitoring are limited. We investigated whether measuring core-related antigen (HBcrAg) after NA cessation may stratify the risk of subsequent clinical relapse (CR).Methods: This retrospective multicenter analysis enrolled adults with CHB who were prospectively monitored discontinuing entecavir or tenofovir negative...
The impact of nucleos(t)ide analogues on intrahepatic viral burden and immune microenvironment in patients with chronic hepatitis B (CHB) is not clear.
Abstract Background Cure rates of hepatitis C virus (HCV) treatment with direct-acting antivirals (DAAs) for patients active and inactive hepatocellular carcinoma (HCC) may differ, but well-controlled studies are limited. We aimed to evaluate DAA outcomes in a large East Asian HCV/HCC population compared HCV/non-HCC patients. Methods Using data from the Real-World Evidence Asia Liver Consortium (REAL-C) registry (Hong Kong, Japan, South Korea, Taiwan), we used propensity score matching (PSM)...
Mac-2 binding protein glycosylation isomer (M2BPGi) is a novel glycoprotein biomarker that correlates with liver fibrosis. It has been investigated in East Asian populations as hepatocellular carcinoma (HCC) biomarker. We assessed M2BPGi an HCC ethnically diverse cohort of patients chronic hepatitis B virus (HBV) and C (HCV) infection. enrolled 947 treatment-naive mono-infected HBV or HCV without at baseline. Biomarker levels were measured from baseline sera correlated longitudinal clinical...