A5024464961- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Alcohol Consumption and Health Effects
- Hepatocellular Carcinoma Treatment and Prognosis
- Diet, Metabolism, and Disease
- Liver Diseases and Immunity
- Colorectal Cancer Screening and Detection
- Hepatitis Viruses Studies and Epidemiology
- Epigenetics and DNA Methylation
- HIV/AIDS drug development and treatment
- Organ Transplantation Techniques and Outcomes
- Systemic Lupus Erythematosus Research
- Gastric Cancer Management and Outcomes
- Folate and B Vitamins Research
- Viral Infections and Immunology Research
- Animal Virus Infections Studies
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer, Lipids, and Metabolism
- Diet and metabolism studies
- Multiple and Secondary Primary Cancers
- Diabetes and associated disorders
Stanford Medicine
2016-2025
Stanford University
2016-2025
VA Palo Alto Health Care System
2016-2025
Palo Alto University
2022-2024
Veterans Health Administration
2004-2024
Queen Mary Hospital
1992-2024
University of Hong Kong - Shenzhen Hospital
2024
University of Hong Kong
1992-2024
Second Affiliated Hospital of Xi'an Jiaotong University
2024
Kaohsiung Medical University
2024
Nonalcoholic steatohepatitis (NASH) is currently the third leading indication for liver transplantation (LT) in U.S. and predicted to become LT near future. The trends NASH-related hepatocellular carcinoma (HCC) among recipients remain undefined. We performed a retrospective cohort study evaluate etiology of HCC adult from 2002 2012, using national data United Network Organ Sharing registry. From 2002-2012, there were 61,868 adults who underwent U.S., including 10,061 patients with HCC....
Hepatitis C virus (HCV) encodes two putative virion glycoproteins (E1 and E2) which are released from the polyprotein by signal peptidase cleavage. In this report, we have characterized complexes formed between E1 E2 (called E1E2) for different HCV strains (H BK) studied their intracellular localization. Vaccinia Sindbis vectors were used to express structural proteins in three cell lines (HepG2, BHK-21, PK-15). The kinetics of association E2, as pulse-chase analysis coprecipitation with an...
It is believed that the hepatitis C virus (HCV)-specific CD8 + cytotoxic T lymphocytes (CTLs) play a role in development of liver cell injury and clearance virus. To develop direct binding assay for HCV-specific CTLs, we generated two peptide-MHC tetramers by using recombinant HLA A2.1 molecule A2-restricted epitopes HCV NS3 protein. With these reagents are able to detect specific cells blood 15 20 HLA-A2 , HCV-infected patients, at frequency ranging from 0.01% 1.2% peripheral cells....
Clinical factors such as age, gender, alcohol use, and age-at-infection influence the progression to cirrhosis but cannot accurately predict risk of developing in patients with chronic hepatitis C (CHC). The aim this study was develop a predictive signature for Caucasian patients. All had well-characterized liver histology clinical factors; DNA extracted from whole blood genotyping. We validated all significant markers genome scan training cohort, selected 361 building. Using "machine...
In the United States, non-alcoholic fatty liver disease (NAFLD) is most common and associated with higher mortality according to data from earlier National Health Nutrition Examination Survey (NHANES) 1988–1994. Our goal was determine NAFLD prevalence in recent 1999–2012 NHANES, risk factors for advanced fibrosis (stage 3–4) mortality. defined as having a States Fatty Liver Index (USFLI) > 30 absence of heavy alcohol use other known diseases. The probability low/high determined by Fibrosis...
Abstract Background Updated prevalence and outcome data for nonobese NAFLD the multi‐ethnic US population is limited. Objectives We aimed to investigate prevalence, clinical characteristics mortality of obese individuals with in United Sates. Methods A retrospective study was conducted using 1999–2016 NHANES databases. determined hazard ratio stratified by obesity status Cox regression log‐rank test. Results Overall 32.3%: 22.7% were 9.6% nonobese, increasing trend over time NAFLD, but not...
Background/Aims: Due to increases in obesity and type 2 diabetes, the prevalence of nonalcoholic fatty liver disease (NAFLD) has also been increasing. Current forecast models may not include non-obese NAFLD. Here, we used Bayesian approach NAFLD through year 2040.Methods: Prevalence data from 245 articles involving 2,699,627 persons were with a hierarchical 2040. Subgroup analyses performed for age, gender, presence metabolic syndrome, region, smoking status. Sensitivity analysis was...
HCC risk in chronic hepatitis B (CHB) is higher the indeterminate phase compared with inactive phase. However, it unclear if antiviral therapy reduces this population. We aimed to evaluate association between and
Hepatitis B virus (HBV), a DNA with human-only reservoir, is worldwide public health problem. transmitted through parenteral or mucosal exposure to infected blood and body fluids. The mode of transmission usually vertical horizontal in highly endemic areas early life, resulting high chronicity rate. In low countries, adulthood self-limiting infection most. prevalence chronic HBV variable, ranging from 0.1% the United States 20-30% some Pacific Island nations. There are an estimated 360...
Hepatitis B virus (HBV) infection remains a major global health problem, exacerbated by poor linkage to care. We aimed determine the prevalence of HBV infection, exposure, self‐reported vaccination, vaccine‐induced immunity, disease awareness, and treatment in United States birthplace race/ethnicity during 1999‐2016. A total 47,628 adult participants National Health Nutrition Examination Survey who completed core antibody (anti‐HBc) surface antigen (HBsAg) tests 47,618 adults (anti‐HBs)...
Background and Aims Survival data among patients with hepatitis C virus (HCV)‐related hepatocellular carcinoma (HCC) after achieving sustained virologic response (SVR) interferon‐free direct‐acting antivirals (DAAs) in both Asian western countries are limited. rates were compared between HCV‐related HCC who untreated for HCV those achieved SVR. Approach Results Using from two U.S. six centers 2005 to 2017, we categorized 1,676 mono‐infected into (untreated group) DAA‐treated SVR (SVR matched...