A5062061231- Helicobacter pylori-related gastroenterology studies
- Gastric Cancer Management and Outcomes
- Gastroesophageal reflux and treatments
- Eosinophilic Esophagitis
- Gastrointestinal disorders and treatments
- Colorectal Cancer Screening and Detection
- Veterinary medicine and infectious diseases
- Gastrointestinal motility and disorders
- Clostridium difficile and Clostridium perfringens research
- Semiconductor materials and devices
- Microscopic Colitis
- Cancer, Lipids, and Metabolism
- Meta-analysis and systematic reviews
- Advancements in Semiconductor Devices and Circuit Design
- Colorectal Cancer Surgical Treatments
- Galectins and Cancer Biology
- Dialysis and Renal Disease Management
- Abdominal vascular conditions and treatments
- Ferroelectric and Negative Capacitance Devices
- Genetic factors in colorectal cancer
- Lipoproteins and Cardiovascular Health
- Mycobacterium research and diagnosis
- Pancreatic and Hepatic Oncology Research
- Liver Disease Diagnosis and Treatment
- Anesthesia and Neurotoxicity Research
National Taiwan University Hospital
2015-2024
National Taiwan University
2013-2024
Hangzhou Medical College
2017
Zhejiang Provincial People's Hospital
2017
Research Center for Environmental Changes, Academia Sinica
2017
I-Shou University
2011
Mackay Memorial Hospital
2008
National Yang Ming Chiao Tung University
2004
Objective A global consensus meeting was held to review current evidence and knowledge gaps propose collaborative studies on population-wide screening eradication of Helicobacter pylori for prevention gastric cancer (GC). Methods 28 experts from 11 countries reviewed the modified statements using Delphi method, with level predefined as ≥80% agreement each statement. The Grading Recommendation Assessment, Development Evaluation (GRADE) approach followed. Results Consensus reached in 26...
The antiferroelectricity in HfZrO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> (HZO) annealed at 600 °C with an abrupt turn ON of FET characteristics SS <inline-formula xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$_{\rm {min}}=23$ </tex-math></inline-formula> mV/dec and {avg}}=50$ over 4 decades notation="LaTeX">$I_{\rm {DS}}$ is demonstrated. near non-hysteresis achieved antiferroelectric-like HZO due to a...
Background: Although cold snare polypectomy (CSP) is considered effective in reducing delayed postpolypectomy bleeding risk, direct evidence supporting its safety the general population remains lacking. Objective: To clarify whether CSP would reduce risk after compared with hot (HSP) population. Design: Multicenter randomized controlled study. (ClinicalTrials.gov: NCT03373136) Setting: 6 sites Taiwan, July 2018 through 2020. Participants: Participants aged 40 years or older polyps of 4 to 10...
<h3>Background</h3> The efficacy of a levofloxacin-based regimen as the first-line treatment and clarithromycin-based second-line for <i>Helicobacter pylori</i> infection remains unknown. aim this study was to assess eradication rates these two regimens using different administration sequences. <h3>Methods</h3> Eligible patients were randomised receive LAL: levofloxacin (750 mg once day), amoxicillin (1000 twice day) lansoprazole (30 7 days, or CAL: clarithromycin (500 days. Patients with...
The efficacy of sequential therapy and the applicability genotypic resistance to guide selection antibiotics in third-line treatment Helicobacter pylori have not been reported. We aimed assess resistance-guided treatment. Genotypic phenotypic resistances were determined patients who failed at least two eradication therapies by PCR with direct sequencing agar dilution test, respectively. retreated containing esomeprazole amoxicillin for first 7 days, followed metronidazole plus...
<h3>Background and objective</h3> Whether there is distinct pathogenesis in subgroups of functional dyspepsia (FD), the postprandial distress syndrome (PDS) epigastric pain (EPS) remains controversial. We aimed to identify risk factors FD its Chinese population. <h3>Methods</h3> Patients with healthy subjects who underwent gastric cancer screening were enrolled this multicentre study from 2010 2012. All patients evaluated by questionnaire, oesophagoduodenoscopy, histological examination...
Objective The Taiwan Government issued a policy to restrict antimicrobial usage since 2001. We aimed assess the changes in antibiotic consumption and primary resistance of H. pylori after this impact virulence factors on resistance. Methods defined daily dose (DDD) antibiotics was analyzed using National Health Insurance (NHI) research database. strains isolated from treatment naïve (N=1395) failure prior eradication therapies (N=360) 9 hospitals between 2000 2012 were used for analysis....
<h3>Objective</h3> Significant heterogeneity was observed in previous trials that assessed the efficacies of sequential therapy for 10 days (S10) versus triple 14 (T14) first-line treatment <i>Helicobacter pylori.</i> We aimed to compare efficacy S10 and T14 assess factors affecting their efficacies. <h3>Design</h3> conducted this open-label randomised multicentre trial eight hospitals one community Taiwan. 1300 adult subjects with <i>H pylori</i> infection naïve were (1:1) receive...
Context: Overexpression of IGF-II and IGF-binding protein (IGFBP)-2 has been reported in several cancers.
The aim of this study was to determine whether statin use exerts a protective effect against pancreatic cancer in Type 2 diabetic patients. A retrospective population-based cohort designed analyze the National Health Insurance Research database (NHIRD) from 1997-2010 Taiwan. total 1,140,617 patients with first-time diagnosis diabetes were enrolled. event defined as newly diagnosed cancer. Cox proportional hazards regression model time-dependent covariates used calculate hazard ratios (HRs)...
INTRODUCTION: Concerns regarding bleeding remain in cold snare polypectomy (CSP) for small pedunculated (0-Ip) polyps. The aim of this study was to compare the risk CSP and hot (HSP) such lesions. METHODS: Data on 0-Ip colorectal polyps ≤10 mm were extracted from a large, pragmatic, randomized trial. Immediate postpolypectomy (IPPB), defined as perioperative use clip bleeding, evaluated through polyp-level analysis. Delayed (DPPB), occurring within 2 weeks postoperatively, assessed at...
The accuracy of genotypic resistance to levofloxacin (gyrA mutations) and its agreement with treatment outcomes after levofloxacin-based therapy have not been reported. We aimed assess the correlation. Helicobacter pylori strains isolated from patients who received clarithromycin-based triple therapies in a previous randomized trial were analyzed for point mutations gyrA 23S rRNA. PCR followed by direct sequencing was used rRNA mutations. An agar dilution test determine MICs clarithromycin...
Objectives: The efficacy of levofloxacin triple therapy has fallen below 80% in the second-line treatment ofHelicobacter pylori (H. pylori).We aimed to assess whether sequential is more effective than treatment. Methods: This open-label, randomized, multicenter trial was conducted between 2012 and 2015.H. pylori-infected subjects who failed from clarithromycin-based regimens (N=600) were randomized (1:1) receive (LS: lansoprazole amoxicillin for first 5 days, followed by lansoprazole,...
Abstract Background Probiotics may alter the gut microbiota and reduce antibiotic‐related dysbiosis after H . pylori eradication. However, whether probiotics are effective in reducing bacterial load of modifying remains unknown. We aimed to assess efficacy Lactobacillus acidophilus rhamnosus microbiota. Materials methods In this double‐blind, randomized, placebo‐controlled trial, we recruited 40 adult subjects with moderate high loads , defined as a mean delta over baseline (DOB) value 13...
Sequential therapy appears to achieve a higher Helicobacter pylori eradication rate than triple therapy. We assessed the efficacy and tolerability of modified sequential containing levofloxacin high-dose esomeprazole in second-line therapy.Patients who failed first-line with clarithromycin, amoxicillin proton pump inhibitor were eligible this multicentre trial. Eligible patients treated 40 mg 1 g for first 5 days, followed by mg, 250 metronidazole 500 another days (all given twice daily)....