A5013393532- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Hepatitis B Virus Studies
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Liver physiology and pathology
- Liver Diseases and Immunity
- Cancer-related molecular mechanisms research
- Liver Disease and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatitis Pathology and Treatment
- Pancreatic function and diabetes
- Pediatric Hepatobiliary Diseases and Treatments
- Organ Transplantation Techniques and Outcomes
- RNA modifications and cancer
- Circular RNAs in diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Metabolism and Genetic Disorders
- Glycosylation and Glycoproteins Research
- IgG4-Related and Inflammatory Diseases
- Diabetes and associated disorders
- Systemic Lupus Erythematosus Research
- Eating Disorders and Behaviors
- Fibroblast Growth Factor Research
- Diet and metabolism studies
Yamagata University
2014-2025
Saiseikai Niigata Daini Hospital
2024
Second Affiliated Hospital of Xi'an Jiaotong University
2024
Kaohsiung Medical University
2024
National Sun Yat-sen University
2024
Japan Agency for Medical Research and Development
2021
Mayo Clinic in Florida
2014-2017
WinnMed
2014-2015
Mayo Clinic
2014
University Gastroenterology
2013
Hepatocellular cancers (HCC) are highly resistant to chemotherapy. TGFβ has been associated with chemoresistance in some human but the mechanisms involved unknown. We explored how might contribute altered responses therapy by assessing involvement and mechanistic contribution of extracellular vesicle long non-coding RNA (lncRNA) mediating TGFβ-dependent chemoresistance. reduced sensitivity HCC cells sorafenib or doxorubicin release both vesicles selected lncRNA within these vesicles. Amongst...
Abstract Hepatocellular cancer (HCC) is a highly treatment-refractory and also resistant to adverse cellular stress. Although cell behavior can be modulated by noncoding RNAs (ncRNA) within extracellular vesicles (EV), the contributions of long (lncRNAs) are largely unknown. To this end, involvement functional roles lncRNAs contained EVs during chemotherapeutic stress in human HCC were determined. Expression profiling identified subset that enriched tumor cell–derived released from two...
Resistance to adverse environmental conditions such as hypoxia contributes the efficacy of anticancer therapies and tumor progression. Although deregulated expression many long non-coding RNA (lncRNA) occur in human cancers, their contributions responses are unknown. profiling identified several hypoxia-responsive lncRNAs including linc-RoR, which is also increased malignant liver cancer cells. Linc-RoR was hypoxic regions within cell xenografts vivo. Tumor viability during reduced by siRNA...
Abstract Stem cell-based therapies have potential for treatment of liver injury by contributing to regenerative responses, through functional tissue replacement or paracrine effects. The release extracellular vesicles (EV) from cells has been implicated in intercellular communication, and may contribute beneficial effects stem therapies. Therapeutic bone-marrow derived mesenchymal (MSC) released these were examined a lethal murine model hepatic failure induced d-galactosamine/tumor necrosis...
The contributions of mesenchymal stem cells (MSCs) to tumour growth and stroma formation are poorly understood. Tumour can transfer genetic information modulate cell signalling in other through the release extracellular vesicles (EVs). We examined contribution EV‐mediated inter‐cellular between bone marrow MSCs human cholangiocarcinoma, highly desmoplastic cancers that characterized by closely intertwined within a dense fibrous stroma. Exposure cell–derived EVs enhanced MSC migratory...
Hepatic ischemia/reperfusion injury (IRI) and associated inflammation contributes to liver dysfunction complications after surgery transplantation. Mesenchymal stem cells (MSCs) have been reported reduce hepatic IRI because of their reparative immunomodulatory effects in injured tissues. Recent studies highlighted beneficial extracellular vesicles from mesenchymal (MSC‐EV) on tissue injury. The systemically administered mouse bone marrow–derived MSC‐EV were evaluated an experimental murine...
Chronic hepatitis B virus (HBV) infection is a leading cause of hepatocellular carcinoma (HCC) worldwide. Nucleos(t)ide analogues (NAs) are widely used in chronically HBV-infected patients, but the risk HCC still remains NA-treated patients. In this study, we aimed to validate scores for patients treated with nucleos(t)ide (NAs). Among total 360 who were NAs, 253 without history PAGE-B, mPAGE-B, PAGED-B, APA-B, and aMAP scores, as well recently developed score, FAL-1 which consists FIB-4...
The present study was conducted to evaluate the application and efficacy of autologous bone marrow infusion (ABMi) for improvement liver function in patients with alcoholic cirrhosis (ALC). Five subjects 5 control ALC who had abstained from alcohol intake 24 weeks before were enrolled. Autologous cells washed injected intravenously, changes serum parameters, level type IV collagen 7S domain as a marker fibrosis, monitored weeks. distribution activated assessed by indium-111-chloride...
Citrin, encoded by SLC25A13, is a component of the malate-aspartate shuttle, which main NADH-transporting system in liver. Citrin deficiency causes neonatal intrahepatic cholestasis (NICCD), usually resolves within first year life. However, small numbers adults with citrin develop hyperammonemic encephalopathy, adult-onset type II citrullinemia (CTLN2), leads to death due cerebral edema. Liver transplantation only definitive therapy for patients CTLN2. We previously reported that lactose...
In recent years, the development of diagnostics using artificial intelligence (AI) has been remarkable. AI algorithms can go beyond human reasoning and build diagnostic models from a number complex combinations. Using next-generation sequencing technology, we identified hepatitis C virus (HCV) variants resistant to directing-acting antivirals (DAA) by whole genome full-length HCV genomes, applied these various machine-learning evaluate preliminary predictive model. genomic RNA was extracted...
Abstract Background Cure rates of hepatitis C virus (HCV) treatment with direct-acting antivirals (DAAs) for patients active and inactive hepatocellular carcinoma (HCC) may differ, but well-controlled studies are limited. We aimed to evaluate DAA outcomes in a large East Asian HCV/HCC population compared HCV/non-HCC patients. Methods Using data from the Real-World Evidence Asia Liver Consortium (REAL-C) registry (Hong Kong, Japan, South Korea, Taiwan), we used propensity score matching (PSM)...
Abstract Extracellular vesicles (EVs) are released from all cells. Bile directly contacts bile duct tumor; bile-derived EVs may contain high concentrations of cancer biomarkers. We performed a proteomic analysis human and identified novel biomarker cholangiocarcinoma (CCA). were isolated using ultracentrifugation, chelating agents, ethylenediaminetetraacetic acid ethylene glycol tetraacetic (EDEG) phosphate buffered saline (PBS) used as dissolution solutions. was collected 10 CCA...
The number of Japanese patients with anorexia nervosa (AN) is increasing as society changes. Mild liver injury a complication AN in around 30% cases. In some rare instances, present severe similar to acute failure. However, there are numerous uncertainties over the clinical characteristics this condition. objective study was clarify complicated by and investigate factors related hepatic complications.Thirty-seven hospitalized at our institution diagnosis were enrolled subjects. used data...
Our research elucidated that the composition of basolateral EVs from biliary epithelial cells changed under bile acid exposure and contained novel inflammation-inducing proteins NPM, NCL, MK fibrosis-inducing protein LECT2. We report these new results are possible to lead potential therapeutic target cholestatic liver diseases in future.
Abstract Objectives While esophageal varices (EVs) are typically treated endoscopically, other options such as interventional radiology or surgical treatment considered when endoscopic is challenging. Pipeline EVs difficult to treat endoscopically due their large diameter, and currently, no specific guidelines have been established. Methods We reviewed cases of pipeline at our hospital analyzed previously reported collect evidence for the formulation guidelines. Additionally, we created EV...
Abstract Background Advanced liver fibrosis in cases of metabolic dysfunction-associated steatotic disease (MASLD) leads to cirrhosis and hepatocellular carcinoma. The current gold standard for is invasive biopsy. Therefore, a less biomarker that accurately reflects the stage highly desirable. Methods This study enrolled 269 patients with biopsy-proven MASLD. Patients were divided into three groups (F0/1 ( n = 41/85), F2 47), F3/4 72/24)) according stage. We performed serum N -glycomics...