A5024765179- Bladder and Urothelial Cancer Treatments
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Colorectal Cancer Surgical Treatments
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Renal and related cancers
- Liver Disease Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Colorectal Cancer Treatments and Studies
- Lymphoma Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Urinary and Genital Oncology Studies
- Gastric Cancer Management and Outcomes
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Colorectal and Anal Carcinomas
- Genetic factors in colorectal cancer
- Hepatitis C virus research
- Medical Imaging and Pathology Studies
- Glioma Diagnosis and Treatment
- Liver Diseases and Immunity
Taipei Medical University Hospital
2018-2025
Taipei Medical University
2018-2025
Taipei Medical University-Shuang Ho Hospital
2020-2025
Wan Fang Hospital
2019-2025
I-Shou University
2011-2018
E-Da Hospital
2011-2018
Creative Commons
2016
National Taiwan University Hospital
2016
Fu Jen Catholic University
2016
Czech Academy of Sciences, Institute of Biotechnology
2013
Purpose:The majority deaths of cancer patients are related to metastasis, thus genes associated with cell motility interest us.SPOCK1 was elected by data mining and serial evaluation.In addition, SPOCK1 has been reported be highly expressed in different human cancers adverse outcomes.Therefore, we validate its prognostic significance urothelial carcinoma (UC).Materials Methods: Real-time RT-PCR assay used detect transcript level 27 urinary tract (UTUC) bladder (UBUC)...
Melanotic Xp11 translocation renal cancer is a recently recognized aggressive epithelioid neoplasm with features overlapping between PEComa, carcinoma, and melanoma. We describe morphologic immunohistochemical characteristics of melanotic occurring in an 18-year-old girl perform molecular genetic studies to analyze its alterations related melanogenetic activities. The tumor was composed solid nests cells bearing abundant clear finely granular eosinophilic cytoplasm separated by delicate...
Despite recent improvements in the diagnosis and treatment, final outcomes patients with nasopharyngeal carcinomas (NPC) still remain suboptimal. Through data mining from published transcriptomic database further bioinformatic validation, fibronectin (FN1) was identified as a differentially upregulated gene NPC tissues, which implicates transition epithelial to mesenchymal phenotype (EMT) promotes metastasis. Given roles of risk stratification frontline therapeutics common carcinomas, such...
Aims Amino acid biosynthesis is one of the cardinal events carcinogenesis that has not been investigated in urothelial carcinoma ( UC ). By data‐mining a published transcriptomic database s urinary bladder UBUC s) GSE 31684), we identified branched‐chain amino transaminase 1 BCAT ) as most significantly stepwise up‐regulated gene during tumour progression among those associated with biosynthetic process GO :0008652). Accordingly, analysed transcript and protein expression their...
Neoadjuvant concurrent chemoradiotherapy has been widely used for rectal cancer to improve local tumor control. The varied response of individual tumors encouraged us search useful biomarkers predict the therapeutic response. study was aimed evaluate prognostic impact lipid biosynthesis-associated in patients treated with preoperative chemoradiotherapy. Through analysis previously published gene expression profiling database focusing on genes associated biosynthesis, we found that HSD17B2...
No animal model studies have been conducted in which the efficacy of herbal compounds has tested against multidrug-resistant Acinetobacter baumannii infections. Very few antibiotics are available for treatment pulmonary infections caused by extensively drug-resistant (XDRAB). To find alternative treatments, traditional Chinese herbs were screened their antimicrobial potential. The present study 30 that traditionally used Taiwan and commonly prescribed heat clearing detoxification. with...
Klebsiella pneumoniae is an important human pathogen causing hospital-acquired and community-acquired infections. Systemic K. infections may be preceded by gastrointestinal colonization, but the basis of this bacterium's interaction with intestinal epithelium remains unclear. Here, we report that Sap (sensitivity to antimicrobial peptides) transporter contributes bacterial-host cell interactions in vivo virulence. Gene deletion showed sapA required for adherence a blood isolate epithelial,...
Urothelial carcinoma (UC) is common cancer worldwide. The molecular aberrations regarding tumor progression remain unclear. Pericellular proteolysis crucial in tumorigenesis, but its significance unexplored UC. By data mining the datasets Gene Expression Omnibus, specifically focus on pathway, and followed by a preliminary validation pilot batch of samples, we identified that upregulation dipeptidyl peptidase 4 (DPP4) was most significantly associated with clinical aggressiveness UCs....
Purpose: Urothelial carcinoma (UC) is a type of tumor, especially the urinary bladder, that affects people worldwide.Clarification its detailed tumor biology and discovery potential targets for developing treatment strategies are imperative because frequent recurrences poor prognosis advanced UCs.By data mining published dataset UC bladder (UCB) transcriptome (GSE31684) from Gene Expression Omnibus, National Center Biotechnology Information (GEO, NCBI), we identified THBS2 was most...
Radiofrequency ablation (RFA) and endoscopic submucosal dissection (ESD) can potentially be applied for early esophageal squamous cell neoplasia (ESCN); however, no study has directly compared these 2 modalities. We retrospectively enrolled the patients with flat-type "large" (length ≥3 cm extending ≥1/2 of circumference esophagus) ESCNs treated endoscopically. The main outcome measurements were complete response at 12 months, adverse events. Of a total 65 patients, 18 RFA 47 ESD. procedure...