A5100656644- Pesticide Residue Analysis and Safety
- Antibiotic Resistance in Bacteria
- Insect and Pesticide Research
- Epigenetics and DNA Methylation
- Metabolism, Diabetes, and Cancer
- Gut microbiota and health
- Analytical Chemistry and Chromatography
- Genomics and Phylogenetic Studies
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Insect-Plant Interactions and Control
- Chromatography in Natural Products
- Genomics, phytochemicals, and oxidative stress
- Vibrio bacteria research studies
- Autophagy in Disease and Therapy
- Fluorine in Organic Chemistry
- Pharmacological Effects of Natural Compounds
- Cancer Mechanisms and Therapy
- interferon and immune responses
- Histone Deacetylase Inhibitors Research
- Peroxisome Proliferator-Activated Receptors
- Diet and metabolism studies
- Retinal Diseases and Treatments
- Plant tissue culture and regeneration
- Drug-Induced Hepatotoxicity and Protection
Wenzhou Medical University
2021-2025
Stomatology Hospital
2022-2025
Sun Yat-sen University
2022-2025
Quzhou University
2018-2025
Ministry of Education of the People's Republic of China
2024-2025
Zhejiang Chinese Medical University
2018-2025
Tongji Hospital
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2025
Huazhong University of Science and Technology
2025
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
2025
A high-performance flexible supercapacitor electrode with a core-shell structure is successfully developed from cellulose nanocrystal (CNC)-stabilized carbon nanotubes (CNTs). By incorporating poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAA), cross-linked nanofibrous membrane (CNT-CNC/PVA-PAA) prepared as the core material via directional electrospinning, followed by thermal treatment. The electrodes are eventually fabricated in situ polymerization of polyaniline (PANI), which was used...
Abstract Reducing the burden of death due to wound infection is an urgent global public health priority. Metal‐phenolic networks (MPNs) have received widespread attention in antimicrobial infections their facile synthesis process, excellent biocompatibility, and properties brought about by polyphenols metal ions. However, typical therapeutic MPNs show rapid release ions poor solution stability, impeding long‐acting efficacy multiple healing stages. To address these issues, copper‐poly...
Reactive oxygen species (ROS) play a pivotal role in macrophage-mediated acute inflammation. However, the precise molecular mechanism by which ROS regulate macrophage polarization remains unclear. Here, we show that function as signaling molecules M1 through ataxia-telangiectasia mutated (ATM) and cell cycle checkpoint kinase 2 (Chk2), vital effector kinases DNA damage response (DDR) pathway. We further demonstrate Chk2 phosphorylates PKM2 at T95 T195 sites, promoting glycolysis facilitating...
Abstract Background Flavonoids are reported to modulate the composition of gut microbiota, which play an important role in preventing obesity and associated metabolic diseases. In this study, we investigated effect Total Quzhou Fructus Aurantii Extract (TFQ) on microbial community mice fed with a high-fat diet (HFD). Methods C57BL/6J were either chow or HFD without oral gavage TFQ (300 mg/kg/day) for 12 weeks. Results Our data indicate significantly reduced obesity, inflammatio,n liver...
Developing motoneurons require trophic support from their target, the skeletal muscle. Despite a large number of neurotrophic molecules with survival-promoting activity for isolated embryonic motoneurons, those factors that are required motoneuron survival during development still not known. Cytokines ciliary factor (CNTF)–leukemia inhibitory (LIF) family have been shown to play role in (MN) survival. Importantly, mice lacking LIFRβ or CNTFRα there is significant loss MNs development....
Increasing evidence indicates several roles for thrombin-like serine proteases and their cognate inhibitors (serpins) in normal development and/or pathology of the nervous system. In addition to its prominent role thrombosis hemostasis, thrombin inhibits neurite outgrowth neuroblastoma primary neuronal cells vitro, prevents stellation glial cells, induces cell death cultures. Thrombin is known act via a surface protease-activated receptor (PAR-1), recent suggests that rodent neurons express...
Abstract The metabolism of cancer cells is highly plastic. Cancer can change their preference for nutrient uptake under stress. Fructose one the most common carbohydrates in diet and its also involved development progression tumors. GLUT5, encoded by SLC2A5 , specific fructose transporter mammalian cells. In this study, we found that significantly upregulated lung adenocarcinoma (LUAD) patients overexpression correlated with poor prognosis LUAD patients. expression determined utilization...
Uric acid metabolic disorder is considered to be the main pathogenesis of uric nephropathy (UN). Smilax glabra Roxb. a traditional Chinese herb which has been used in treatment gout, but mechanism was unclear. In this study, we investigated protective effects flavonoid-rich fraction from rhizomes (SGF) on rats and its underlying mechanisms promoting excretion. Sprague Dawley (SD) were induced by high purine diet (yeast pellets + adenine) for 5 weeks. Rats orally treated with SGF or...
Introduction: Rheumatoid arthritis is an autoimmune disease characterized by chronic joint inflammation. Methotrexate one of the most effective drugs for rheumatoid arthritis, but adverse reactions caused oral methotrexate greatly limit its clinical application. Transdermal drug delivery system ideal alternative to absorbing into human body through skin. However, in existing microneedles mostly used alone, and there are few reports combined use with other anti-inflammatory drugs. Methods: In...
Abstract Backgrounds Mitochondria plays a critical role in the development and pathogenesis of nonalcoholic fatty liver disease (NAFLD). Neohesperidin (NHP) could lower blood glucose prevent obesity mice. However, direct effect NHP on hepatic steatosis has not been reported. Methods Mice were fed with either chow diet or HFD without oral gavage for 12 weeks. A variety biochemical histological indicators examined. In vitro cell culture model was utilized to demonstrate underlying molecular...
There is a growing body of evidence which suggests that intestinal microbiota, especially Fusobacterium nucleatum ( F. ), are associated with immune disease such as ulcerative colitis (UC). The mechanism by promotes epithelial cell (IEC) death remained undefined. Here, we investigated the potential mechanisms about how aggravates IEC in UC. We first detected abundance UC tissues and analyzed its relationship clinical characteristics Next, explored whether vitro vivo . Furthermore, extracted...
An efficient Ni–(S,S)-Ph-BPE complex that catalyzed asymmetric hydrogenation of cyclic N-acyl hydrazones has been developed to produce various chiral hydrazines in high yields with excellent enantioselectivities up >99% enantiomeric excess. Moreover, the can not only proceed smoothly on a gram scale under lower catalyst loading (S/C = 3000) without any decrease enantioselectivity but also be applied synthesis RIP-1 kinase inhibitor.
Cinobufacini is a traditional Chinese medicine used clinically that has antitumor and anti-inflammatory effects. It improves colitis outcomes in the clinical setting, but mechanism underlying its function yet to be uncovered. We investigated protective effects mechanisms of cinobufacini on using dextran sulfate sodium (DSS)-induced mouse model, mainly focusing impact macrophage polarization. Our results showed dramatically ameliorated DSS-induced mice. treatment reduced infiltration...
Abstract An iron‐catalyzed hydrofluorination of unactivated alkenes has been developed. The use a multidentate ligand and the fluorination reagent N ‐fluorobenzenesulfonimide (NFSI) proved to be critical for this reaction, which afforded various fluorinated compounds in up 94 % yield.
Modern accumulations of genetic data offer unprecedented opportunities for understanding the systematic classification and origins specific groups organisms. The genus Sinocyclocheilus is among most cave abundant genera in Cyprinidae, with 76 recognized species, belonging to 4 species groups. Recent phylogenetic studies have shown that within remains controversial. In this study, we constructed a sequence supermatrix 26 from using mitochondrial genome reveal relationships, historical...
Intercropping can reduce agricultural pest incidence and represents an important sustainable alternative to conventional control methods. Citrus intercropped with guava (Psidium guajava L.) has a lower of Asian citrus psyllid (ACP, Diaphorina citri Kuwayama) huanglongbing disease (HLB), but the mechanisms are still unknown. In this study, we tested whether volatile organic compounds (VOCs) emitted by plants play role in plant-plant communications trigger defense responses sweet orange...