Shuhui Sun
A5101888153- Single-cell and spatial transcriptomics
- Epigenetics and DNA Methylation
- Systemic Lupus Erythematosus Research
- Ferroelectric and Piezoelectric Materials
- Telomeres, Telomerase, and Senescence
- Multiferroics and related materials
- Genetics, Aging, and Longevity in Model Organisms
- Inflammatory Myopathies and Dermatomyositis
- Neuroinflammation and Neurodegeneration Mechanisms
- interferon and immune responses
- Ocular Diseases and Behçet’s Syndrome
- Neurogenesis and neuroplasticity mechanisms
- Inflammasome and immune disorders
- Immune cells in cancer
- Pluripotent Stem Cells Research
- Mesenchymal stem cell research
- Circadian rhythm and melatonin
- Genetics and Neurodevelopmental Disorders
- Dietary Effects on Health
- Hepatitis B Virus Studies
- Extracellular vesicles in disease
- Cancer Cells and Metastasis
- Platelet Disorders and Treatments
- Dielectric properties of ceramics
- Systemic Sclerosis and Related Diseases
Chinese Academy of Sciences
2019-2025
Renji Hospital
2016-2025
Shanghai Jiao Tong University
2019-2025
Institute of Zoology
2019-2025
University of Chinese Academy of Sciences
2019-2025
Beijing Anzhen Hospital
2024-2025
Capital Medical University
2024-2025
Sanya University
2025
Hainan University
2025
Shandong Jianzhu University
2024
Organismal aging is driven by interconnected molecular changes encompassing internal and extracellular factors. Combinational analysis of high-throughput 'multi-omics' datasets (gathering information from genomics, epigenomics, transcriptomics, proteomics, metabolomics pharmacogenomics), at either populational or single-cell levels, can provide a multi-dimensional, integrated profile the heterogeneous process with unprecedented throughput detail. These new strategies allow for exploration...
Inactivation of the histone acetyltransferase gene KAT7 prolongs survival in naturally aged mice and progeroid that age prematurely.
•An atlas of age-, tissue-, and cell-type-specific benefits long-term exercise.•Exercise protects tissues from infectious injury, especially in younger ones.•Exercise promotes rejuvenation aged tissues, the nervous system.•Exercise exerts geroprotective effects, by resetting circadian programs via clock protein BMAL1. Exercise whole organism, yet, how across body orchestrally respond to exercise remains enigmatic. Here, young old mice, with or without exercise, exposed we characterized...
Aging is a major risk factor for many diseases, especially in highly prevalent cardiopulmonary comorbidities and infectious diseases including Coronavirus Disease 2019 (COVID-19). Resolving cellular molecular mechanisms associated with aging higher mammals therefore urgently needed. Here, we created young old non-human primate single-nucleus/cell transcriptomic atlases of lung, heart artery, the top tissues targeted by SARS-CoV-2. Analysis cell type-specific aging-associated transcriptional...
The hippocampus plays a crucial role in learning and memory, its progressive deterioration with age is functionally linked to variety of human neurodegenerative diseases. Yet systematic profiling the aging effects on various hippocampal cell types primates still missing. Here, we reported new aging-associated phenotypic changes primate hippocampus. These include, particular, increased DNA damage heterochromatin erosion time, alongside loss proteostasis elevated inflammation. To understand...
Progressive functional deterioration in the cochlea is associated with age-related hearing loss (ARHL). However, cellular and molecular basis underlying cochlear aging remains largely unknown. Here, we established a dynamic single-cell transcriptomic landscape of mouse aging, which characterized aging-associated changes 27 different cell types across five time points. Overall, our analysis pinpoints proteostasis elevated apoptosis as hallmark features highlights unexpected transcriptional...
Aging increases the risk of liver diseases and systemic susceptibility to aging-related diseases. However, cell type-specific changes underlying mechanism aging in higher vertebrates remain incompletely characterized. Here, we constructed first single-nucleus transcriptomic landscape primate aging, which resolved gene expression fluctuation hepatocytes across three zonations detected aberrant cell-cell interactions between niche cells. Upon in-depth dissection this rich dataset, identified...
The primate frontal lobe (FL) is sensitive to aging-related neurocognitive decline. However, the aging-associated molecular mechanisms remain unclear. Here, using physiologically aged non-human primates (NHPs), we depicted a comprehensive landscape of FL aging with multidimensional profiling encompassing bulk and single-nucleus transcriptomes, quantitative proteome, DNA methylome. Conjoint analysis across these neuropathological layers underscores nuclear lamina heterochromatin erosion,...
This study examines whether genetic susceptibility vs resistance to experimental autoimmune uveoretinitis (EAU) in mice is associated with dominant type 1 2 cytokine response profiles. Mice from six strains were immunized the uveitogenic retinal Ag IRBP. EAU was evaluated by histopathology. As judged disease scores, three of susceptible, one minimally and two resistant. Ag-specific responses (protein and/or mRNA) draining lymph node cells, IgG2a IgG1 Ab isotypes IRBP, measured as indicators...
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a rare hereditary cerebrovascular disease caused by NOTCH3 mutation. However, the underlying cellular molecular mechanisms remain unidentified. Here, we generated non-integrative induced pluripotent stem cells (iPSCs) from fibroblasts of CADASIL patient harboring heterozygous mutation (c.3226C>T, p.R1076C). Vascular smooth muscle (VSMCs) differentiated CADASIL-specific iPSCs showed gene...
RAP1 is a well-known telomere-binding protein, but its functions in human stem cells have remained unclear. Here we generated RAP1-deficient embryonic (hESCs) by using CRISPR/Cas9 technique and obtained mesenchymal (hMSCs) neural (hNSCs) via directed differentiation. In both hMSCs hNSCs, not only negatively regulated telomere length also acted as transcriptional regulator of RELN tuning the methylation status gene promoter. deficiency enhanced self-renewal delayed senescence hMSCs,...