A5077053050- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Radical Photochemical Reactions
- Optical Coherence Tomography Applications
- Aortic aneurysm repair treatments
- Glioma Diagnosis and Treatment
- Catalytic C–H Functionalization Methods
- Cancer-related molecular mechanisms research
- Environmental remediation with nanomaterials
- COVID-19 Clinical Research Studies
- Sulfur-Based Synthesis Techniques
- Solar Radiation and Photovoltaics
- Ferroptosis and cancer prognosis
- Behavioral Health and Interventions
- Service-Oriented Architecture and Web Services
- Advanced Algorithms and Applications
- Peer-to-Peer Network Technologies
- Structural Behavior of Reinforced Concrete
- Oxidative Organic Chemistry Reactions
- Health Literacy and Information Accessibility
- Aortic Disease and Treatment Approaches
- Gut microbiota and health
- Optical Polarization and Ellipsometry
- Photovoltaic System Optimization Techniques
- Misinformation and Its Impacts
Macau University of Science and Technology
2022-2025
Zhejiang Chinese Medical University
2025
Army Medical University
2017-2024
North Dakota State University
2011-2024
Institute of Cardiology
2024
Northeast Agricultural University
2024
South China University of Technology
2016-2024
Southwest Hospital
2019-2024
Anyang Institute of Technology
2024
Minzu University of China
2024
Malignant gliomas are largely refractory to immune checkpoint blockade (ICB) therapy. To explore the underlying regulators, we examine microenvironment in glioma and find that tumor-infiltrating T cells mainly confined perivascular cuffs express high levels of CCR5, CXCR3, programmed cell death protein 1 (PD-1). Combined analysis clustering with receptor (TCR) clone expansion shows potential tumor-killing categorized into pre-exhausted/exhausted effector CD8+ subsets, as well cytotoxic CD4+...
Abstract Glioblastoma (GBM) is a prevalent and highly lethal form of glioma, with rapid tumor progression frequent recurrence. Excessive outgrowth pericytes in GBM governs the ecology perivascular niche, but their function mediating chemoresistance has not been fully explored. Herein, we uncovered that potentiate DNA damage repair (DDR) cells residing which induces temozolomide (TMZ) chemoresistance. We found increased pericyte proportion correlates accelerated recurrence worse prognosis....
Glioblastoma (GB) is the most common and highly malignant brain tumor characterized by aggressive growth resistance to alkylating chemotherapy. Autophagy induction one of hallmark effects anti-GB therapies with temozolomide (TMZ). However, non-classical form autophagy, autophagy-based unconventional secretion, also called secretory autophagy its role in regulating sensitivity GB TMZ remains unclear. There an urgent need illuminate mechanism develop novel therapeutic targets for GB.Cancer...
Background Healthy lifestyle improvement of older Chinese adults has drawn a lot attention due to an exceeding ageing population in mainland China. The current study aims investigate the beneficial functions multi-channel health information seeking on elders’ self-management. Objective We conducted mediation analysis test association between behavior and self-management, which mediates by perceived self-management competence. Meanwhile, we also moderation effect competence management with...
High-grade glioma (HGG) is a fatal human cancer. Bortezomib, proteasome inhibitor, has been approved for the treatment of multiple myeloma but its use in awaits further investigation. This study aimed to explore chemotherapeutic effect and underlying mechanism bortezomib on gliomas. U251 U87 cell viability proliferation were detected by 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay, tumor spheroid growth, colony formation assay. Cell apoptosis cycle flow...
Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics facilitate development novel therapeutics. In this study, we report findings from lungs lymphatic organs 12 decedents-findings that evaluated histopathological changes, immune cell signature inflammatory factor expression in lungs, spleen lymph nodes. Here show major pulmonary alterations included diffuse alveolar damage, interstitial fibrosis exudative...
Gliomas are the most common primary tumors in central nervous system. The prognosis of patients with glioma is poor regardless development therapeutic strategies. Its aggressive behavior mainly depends on potent ability proliferation. transcription factor EGR1 (early growth response 1) a member zinc finger family which plays an essential role cell and proliferation.EGR1 expression levels 39 tissues 10 normal brain were tested by RT-qPCR Western-blotting. effects U251 cells, stem-like cells...
Abstract Vascular smooth muscle cell (VSMC) phenotypic switching plays a critical role in the formation of abdominal aortic aneurysms (AAAs). FoxO3a is key suppressor VSMC homeostasis. We found that human and animal AAA tissues, was upregulated, SM22α α-smooth actin (α-SMA) proteins were downregulated synthetic markers indicating occurred these diseased tissues. In addition, cultured VSMCs, significant enhancement expression during angiotensin II (Ang II)-induced switching. vivo,...
Abstract Background The gut microbiome plays an important role in various cardiovascular diseases, such as atherosclerosis and hypertension, which are associated with abdominal aortic aneurysms (AAAs). Methods Here, we used 16S rRNA sequencing to explore microbiota C57BL ApoE −/− mice AAAs. A mouse model of was induced angiotensin II (Ang II) (1000 ng/min per kg). On day 28 after the operation, fecal samples were collected stored at − 80 °C until DNA extraction. We determined relative...
Thanks to their accessibility and low cost, electronic personal health information (ePHI) technologies have been widely used facilitate patient-physician communication promote prevention behaviors (e.g. cancer screening). Despite that empirical evidence has supported the association between ePHI technology use screening behaviors, underlying mechanism through which influences remains a topic of discussion.This study investigates relationship uses American women examines mediating role...
The aim of this paper is to study the flexural behavior reinforced concrete (RC) beams by engineered cementitious composite (ECC). reinforcement effect ECC on RC beam studied experiments, numerical simulation and theoretical analysis, considering secondary load. Five were tested under static load, including two with layers at top bottom (TBEB), (BEB) one unreinforced beam. Different parameters in test include ratio, whether equipped layer, thickness layer. data used validate finite element...
Abstract Background Polyphyllin VII (PP7), a steroidal saponin from P. polyphylla has been found to exert strong anticancer activity. Little is known about the anti-angiogenesis and anti-metastasis properties of PP7. In this study, anti-angiogenic anti-metastatic effects PP7 on HCC molecular mechanisms were evaluated. Methods Effect angiogenesis was assessed by tube formation assay applied transgenic Tg(fli1:EGFP) zebrafish model. Effects tumor metastasis invasion examined in cell migration...
Multi-task optimization (MTO) algorithms aim to simultaneously solve multiple tasks. Addressing issues such as limited precision and high computational costs in existing MTO algorithms, this article proposes a multi-task snake (MTSO) algorithm. The MTSO algorithm operates two phases: first, independently handling each problem; second, transferring knowledge. Knowledge transfer is determined by the probability of knowledge selection elite individuals. Based on decision, either transfers from...