A5002705877- Cardiovascular Disease and Adiposity
- COVID-19 Clinical Research Studies
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Long-Term Effects of COVID-19
- Cardiovascular Effects of Exercise
- SARS-CoV-2 and COVID-19 Research
- Advanced MRI Techniques and Applications
- Atrial Fibrillation Management and Outcomes
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Cardiac Structural Anomalies and Repair
- Cardiac Arrhythmias and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- COVID-19 and healthcare impacts
- Cardiac Valve Diseases and Treatments
- Retinal Imaging and Analysis
- Retinal and Optic Conditions
- Pulmonary Hypertension Research and Treatments
- Sports injuries and prevention
- Acute Myocardial Infarction Research
- Cardiomyopathy and Myosin Studies
- Cardiac electrophysiology and arrhythmias
- Reproductive Biology and Fertility
Capital Medical University
2016-2025
Beijing Anzhen Hospital
2015-2025
Fifth Hospital of Shijiazhuang
2021-2025
Huzhou University
2025
Zhejiang University
2025
Shanghai Jiao Tong University
2020-2025
Shanghai First People's Hospital
2025
Beijing Chao-Yang Hospital
2019-2024
Changchun University of Chinese Medicine
2024
Renji Hospital
2024
The dynamic changes of lymphocyte subsets and cytokines profiles patients with novel coronavirus disease (COVID-19) their correlation the severity remain unclear.
To figure out whether diabetes is a risk factor influencing the progression and prognosis of 2019 novel coronavirus disease (COVID-19).A total 174 consecutive patients confirmed with COVID-19 were studied. Demographic data, medical history, symptoms signs, laboratory findings, chest computed tomography (CT) as well treatment measures collected analysed.We found that without other comorbidities but (n = 24) at higher severe pneumonia, release tissue injury-related enzymes, excessive...
The novel coronavirus pneumonia COVID-19 caused by SARS-CoV-2 infection could lead to a series of clinical symptoms and severe illnesses, including acute respiratory distress syndrome (ARDS) fatal organ failure. We report the fundamental pathological investigation in lungs other organs cases for mechanistic understanding development specific therapy these cases.
Background: The dynamic changes of lymphocyte subsets and cytokines profiles patients with novel coronavirus disease (COVID-19) their correlation the severity remain unclear. Method: Peripheral blood samples were longitudinally collected from 40 confirmed COVID-19 examined for by flow cytometry cytokine specific immunoassays. Findings: Of enrolled, 13 severe cases showed significant sustained decreases in counts but increases neutrophil than 27 mild cases. Further analysis demonstrated T...
Abstract Severe COVID-19 disease caused by SARS-CoV-2 is frequently accompanied dysfunction of the lungs and extrapulmonary organs. However, organotropism port virus entry for systemic dissemination remain largely unknown. We profiled 26 autopsy cases from four cohorts in Wuhan, China, determined distribution SARS-CoV-2. was detected multiple organs critically ill patients up to 67 days after symptom onset. Based on pathological features patients, divided into viral intrapulmonary subtypes....
Cardiac magnetic resonance imaging (CMR) is the gold standard for cardiac function assessment and plays a crucial role in diagnosing cardiovascular disease (CVD). However, its widespread application has been limited by heavy resource burden of CMR interpretation. Here, to address this challenge, we developed validated computerized interpretation screening diagnosis 11 types CVD 9,719 patients. We propose two-stage paradigm consisting noninvasive cine-based followed cine late gadolinium...
Human pre-implantation embryonic development involves extensive changes in chromatin structure and transcriptional activity. Here, we report on LiCAT-seq, a technique that enables simultaneous profiling of accessibility gene expression with ultra-low input cells, map the transcriptome landscapes for human embryos. We observed global difference between sperm all stages embryos, finding accessible regions tend to occur gene-poor genomic regions. Integrative analyses two datasets reveals strong...
Highlights•The COVID-19 patients with CVD experienced more severe pneumonia.•The showed tissue injury-related enzymes release.•The were at higher risk of cytokine storm.•The hypercoagulable state.•CVD is a factor for the progression and prognosis COVID-19.AbstractBackground aimA novel coronavirus acute respiratory syndrome corona virus 2 (SARS-CoV-2) caused pneumonia, Coronavirus Disease 2019 (COVID-19), broke out in Wuhan, China December 2019, spread all over world. Patients huge...
Abstract Background The dynamic changes of lymphocyte subsets and cytokines profiles patients with novel coronavirus disease (COVID-19) their correlation the severity remain unclear. Methods Peripheral blood samples were longitudinally collected from 40 confirmed COVID-19 examined for by flow cytometry cytokine specific immunoassays. Results Of enrolled, 13 severe cases showed significant sustained decreases in counts but increases neutrophil than 27 mild cases. Further analysis demonstrated...
Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics facilitate development novel therapeutics. In this study, we report findings from lungs lymphatic organs 12 decedents-findings that evaluated histopathological changes, immune cell signature inflammatory factor expression in lungs, spleen lymph nodes. Here show major pulmonary alterations included diffuse alveolar damage, interstitial fibrosis exudative...
An outbreak of pneumonia caused by a novel coronavirus (COVID-19) began in Wuhan, China December 2019 and quickly spread throughout the country world. efficient convenient method based on clinical characteristics was needed to evaluate potential deterioration patients. We aimed develop simple practical risk scoring system predict severity COVID-19 patients admission. retrospectively investigated information confirmed from 10 February 2020 29 Wuhan Union Hospital. Predictors were identified...
SummaryBackgroundThe outbreak of COVID-19 has led to international concern. We aimed establish an effective screening strategy in Shanghai, China, aid early identification patients with COVID-19.MethodsWe did a multicentre, observational cohort study fever clinics 25 hospitals 16 districts Shanghai. All visiting the within period were included. A for was presented and then suspected cases monitored analysed until they confirmed as or excluded. Logistic regression used determine risk factors...
Abstract Aims The molecular signatures in epicardial adipose tissue (EAT) that contribute to the pathogenesis of heart failure with preserved ejection fraction (HFpEF) are poorly characterized. In this study, we sought elucidate including genetic transcripts and long non‐coding RNAs (lncRNAs) EAT might modulate HFpEF development. Methods RNA sequencing (RNA‐seq) was performed identify differentially expressed lncRNAs mRNAs samples from patients ( n = 5) without HF (control, who underwent...
Reference values on atrial and ventricular strain from cardiovascular magnetic resonance (CMR) are essential in identifying patients with impaired function. However, reference have not been established for Chinese subjects. One hundred fifty healthy volunteers (75 Males/75 Females; 18-82 years) were recruited. All underwent CMR scans images acceptable further analysis. Subjects stratified by age: Group 1, 18-44 years; 2, 45-59 3, ≥60 years. Feature tracking of cine imaging was used to obtain...
Epicardial adipose tissue (EAT) is a metabolically active visceral fat depot closely linked to the pathogenesis of heart failure (HF). But molecular signatures related mechanism HF have not been systematically explored. Here, we present comprehensive proteomic analysis EAT in patients and non-HF as controls. A total 771 proteins were identified liquid chromatography-tandem mass spectrometry experiments. Amongst them, 17 increased abundance seven decreased. They involved HF-related processes...
Accumulating studies have suggested that epicardial adipose tissue (EAT) play an important role in the pathogenesis of atrial fibrillation (AF), but few characterized underlying mechanism between their interactions. Recent evidence bioactive molecules secreted from EAT, including exosomes carrying long non-coding RNAs (lncRNAs), may modulate remodeling. LncRNAs are associated with cardiovascular disorders, AF, roles EAT remain elusive. The aim present study was to investigate expression...
Direct myocardial and vascular injuries due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection-driven inflammation is the leading cause of cardiac injury associated with disease 2019 (COVID-19). However, in-depth knowledge characteristics heart affected by lacking. In this study, using a quantitative spatial proteomics strategy that combines comparative anatomy, laser-capture microdissection, histological examination, we establish region-resolved proteome map myocardia...
A complete diagnostic autopsy is the gold-standard to gain insight into Coronavirus disease 2019 (COVID-19) pathogenesis. To delineate in situ immune responses SARS-CoV-2 viral infection, here we perform comprehensive high-dimensional transcriptional and spatial profiling 22 COVID-19 decedents from Wuhan, China. We find TIM-3-mediated PD-1-mediated immunosuppression as a hallmark of severe COVID-19, particularly men, with PD-1+ cells being proximal rather than distal TIM-3+ cells....
Natural medicines possess significant research and application value in the field of atherosclerosis (AS) treatment. The study was performed to investigate impacts a natural drug component, notoginsenoside R1, on development potential mechanisms.