A5083451922- Immune Cell Function and Interaction
- Ocular Diseases and Behçet’s Syndrome
- Trypanosoma species research and implications
- Cytomegalovirus and herpesvirus research
- Immunodeficiency and Autoimmune Disorders
- T-cell and B-cell Immunology
- Toxoplasma gondii Research Studies
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Systemic Lupus Erythematosus Research
- Immunotherapy and Immune Responses
- Herpesvirus Infections and Treatments
- Research on Leishmaniasis Studies
- Long-Term Effects of COVID-19
- interferon and immune responses
- Ocular Surface and Contact Lens
- Dermatology and Skin Diseases
- Allergic Rhinitis and Sensitization
- Neurogenetic and Muscular Disorders Research
- Corneal Surgery and Treatments
- Vaccine Coverage and Hesitancy
- Reproductive System and Pregnancy
- Synthesis and Biological Evaluation
- Viral Infections and Immunology Research
- Cardiomyopathy and Myosin Studies
Hospital Israelita Albert Einstein
2016-2025
Universidade de São Paulo
2003-2024
Centro Universitário Barão de Mauá
2024
Faculdade de Medicina de São José do Rio Preto
2024
Insper
2011-2022
Instituto de Ensino e Pesquisa Santa Casa
2020
Spaulding Rehabilitation Hospital
2019
Harvard University
2019
Hospital São Paulo
2009-2017
National Institutes of Health
1995-2016
BackgroundThe efficacy and safety of tofacitinib, a Janus kinase inhibitor, in patients who are hospitalized with coronavirus disease 2019 (Covid-19) pneumonia unclear.MethodsWe randomly assigned, 1:1 ratio, adults Covid-19 to receive either tofacitinib at dose 10 mg or placebo twice daily for up 14 days until hospital discharge. The primary outcome was the occurrence death respiratory failure through day 28 as assessed use an eight-level ordinal scale (with scores ranging from 1 8 higher...
Previous studies have shown a high prevalence of toxoplasmosis and the frequent occurrence ocular disease in Brazil.To identify genotypes parasite strains associated with disease, we compared 25 clinical animal isolates Toxoplasma gondii from Brazil to previously characterized clonal lineages North America Europe.Multilocus nested polymerase chain reaction analysis was combined direct sequencing polymorphic intron classify by phylogenetic methods.The T. isolated were highly divergent when...
We performed a systematic literature review and meta-analysis on the effectiveness of coronavirus disease 2019 (COVID-19) vaccination against post-COVID conditions (long COVID) among fully vaccinated individuals.Systematic review/meta-analysis.We searched PubMed, Cumulative Index to Nursing Allied Health, EMBASE, Cochrane Central Register Controlled Trials, Scopus, Web Science from December 1, 2019, June 2, 2023, for studies evaluating COVID-19 vaccine (VE) individuals who received two doses...
To evaluate the safety and potential therapeutic activity of humanized anti-IL-2 receptor mAb (Daclizumab) therapy in treatment patients with severe, sight-threatening, intermediate posterior noninfectious uveitis, a nonrandomized, open-label, pilot study was performed. Patients uveitis were treated minimum 20 mg prednisone, cyclosporine, antimetabolites, or any combination these agents eligible. weaned off their systemic immunosuppressive according to standardized schedule, while ultimately...
Efforts have been made to correctly characterize the role of immune response in endometriosis. The objective this study was analyse interaction between Th1 and Th2 patterns endometriosis by evaluating a panel cytokines. Between January 2004 November 2005, 98 patients, classified into two groups according histologically confirmed presence (Group A) or absence B), were evaluated. Interleukins (IL) 2, 4 10, tumour necrosis factor-alpha interferon-gamma (IFN-gamma) measured flow cytometry...
Pathogenic effector T cells in experimental autoimmune uveitis (EAU) are helper type 1-like, and interleukin (IL)-12 is required for their generation function. Therefore, we expected that IL-12 administration would have disease-enhancing effects. Mice were immunized with a uveitogenic regimen of the retinal antigen interphotoreceptor retinoid-binding protein, treated (100 ng/d 5 d), EAU was assessed by histopathology. Unexpectedly, treatment failed to enhance resistant strains downregulated...
Experimental autoimmune uveitis (EAU) is a T cell-mediated disease that targets the neural retina and serves as model of human uveitis. Uveitogenic effector cells have Th1-like phenotype (high IFN-gamma, low IL-4), genetic susceptibility to EAU associated with an elevated Th1 response. Here we investigate whether ability produce IFN-gamma necessary for development by immunizing IFN-gamma-deficient (GKO) mice uveitogenic protein interphotoreceptor retinoid binding (IRBP) characterize...
Abstract Intraocular inflammatory diseases are a common cause of severe visual impairment and blindness. In this study, we investigated the immunoregulatory role galectin-1 (Gal-1), an endogenous lectin found at sites T cell activation immune privilege, in experimental autoimmune uveitis (EAU), Th1-mediated model retinal disease. Treatment with rGal-1 either early or late during course interphotoreceptor retinoid-binding protein-induced EAU was sufficient to suppress ocular pathology,...
Objective This study describes epidemiological and clinical features of patients with confirmed infection by SARS-CoV-2 diagnosed treated at Hospital Israelita Albert Einstein , which admitted the first this condition in Brazil. Methods In retrospective, single-center study, we included all laboratory COVID-19 cases São Paulo, Brazil, from February until March 2020. Demographic, clinical, radiological data were analyzed. Results A total 510 a diagnosis [...]
Abstract Objective: To determine risk factors for the development of long coronavirus disease 2019 (COVID-19) in healthcare personnel (HCP). Methods: We conducted a case–control study among HCP who had confirmed symptomatic COVID-19 working Brazilian system between March 1, 2020, and July 15, 2022. Cases were defined as those having COVID according to Centers Disease Control Prevention definition. Controls documented but did not develop COVID. Multiple logistic regression was used assess...
This study examines whether genetic susceptibility vs resistance to experimental autoimmune uveoretinitis (EAU) in mice is associated with dominant type 1 2 cytokine response profiles. Mice from six strains were immunized the uveitogenic retinal Ag IRBP. EAU was evaluated by histopathology. As judged disease scores, three of susceptible, one minimally and two resistant. Ag-specific responses (protein and/or mRNA) draining lymph node cells, IgG2a IgG1 Ab isotypes IRBP, measured as indicators...
The role of IL-10 in the regulation ocular autoimmune disease was studied experimental uveoretinitis (EAU) elicited mice by immunization with retinal antigen interphotoreceptor retinoid binding protein. IL-10-deficient were susceptible to EAU, indicating that pathogenesis can occur without presence IL-10. Treatment normal for 5 days after uveitogenic ameliorated subsequent EAU scores, and down-regulated antigen-specific production tumor necrosis factor-alpha IFN-gamma. A concomitant...
<h3>Background and aims</h3> Toxoplasmic retinochoroiditis may recur months or years after the primary infection. Rupture of dormant cysts in retina is accepted hypothesis to explain recurrence. Here, authors present evidence supporting presence <i>Toxoplasma gondii</i> peripheral blood immunocompetent patients. <h3>Methods</h3> Direct observation by light microscopy immunofluorescence assay was performed, results were confirmed PCR amplification parasite DNA. <h3>Results</h3> The studied 20...
Coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) collection began in two Brazilian hospitals for treatment of severe/critical patients.Mild/moderate COVID-19 convalescents were selected as CCP donors after reverse transcription polymerase chain reaction (RT-PCR) confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and absence symptoms ≥14 days plus (a) age (18-60 years), body weight greater than 55 kg; (b) immunohematological studies; (c) no...
Although multiple studies have revealed that coronavirus disease 2019 (COVID-19) vaccines can reduce COVID-19-related outcomes, little is known about their impact on post-COVID-19 conditions. We performed a systematic literature review and meta-analysis the effectiveness of COVID-19 vaccination against conditions (ie, long COVID).
Abstract Protection from the development of experimental autoimmune uveitis (EAU) can be induced by feeding mice interphotoreceptor retinoid binding protein before uveitogenic challenge with same protein. Two different regimens are equally effective in inducing protective tolerance, although they seem to do so through mechanisms: one involving regulatory cytokines (IL-4, IL-10, and TGF-β), other minimal involvement cytokines. Here we studied importance IL-4 IL-10 for oral tolerance using...
The present study addresses the feasibility of potentiating oral tolerance by immunomanipulation, using murine model experimental autoimmune uveoretinitis (EAU) induced immunization with retinal antigen interphotoreceptor retinoid binding protein (IRBP). Three feedings 0.2 mg IRBP every other day before did not protect against EAU, whereas a similar regimen five doses was protective. However, supplementing nonprotective 3x as little one injection 1,000 U human recombinant interleukin-2...