A5101626352- Gout, Hyperuricemia, Uric Acid
- Alcohol Consumption and Health Effects
- Adipose Tissue and Metabolism
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Sarcoma Diagnosis and Treatment
- Pancreatic function and diabetes
- Metabolomics and Mass Spectrometry Studies
- Traditional Chinese Medicine Analysis
- Exercise and Physiological Responses
- Photonic and Optical Devices
- Endoplasmic Reticulum Stress and Disease
- Chemistry and Chemical Engineering
- Spondyloarthritis Studies and Treatments
- Chemical Reactions and Mechanisms
- Plant-based Medicinal Research
- Metastasis and carcinoma case studies
- Cardiac Ischemia and Reperfusion
- Mesenchymal stem cell research
- CO2 Reduction Techniques and Catalysts
- Cardiac pacing and defibrillation studies
- Tissue Engineering and Regenerative Medicine
- Metabolism and Genetic Disorders
- Medicinal plant effects and applications
Yangzhou University
2023
Zhejiang Chinese Medical University
2018-2022
Shanghai University of Sport
2017-2020
Robert Bosch (Germany)
2020
Qingdao Eighth People's Hospital
2018
China Pharmaceutical University
2015-2017
Third People's Hospital of Yunnan Province
2015
Uric acid metabolic disorder is considered to be the main pathogenesis of uric nephropathy (UN). Smilax glabra Roxb. a traditional Chinese herb which has been used in treatment gout, but mechanism was unclear. In this study, we investigated protective effects flavonoid-rich fraction from rhizomes (SGF) on rats and its underlying mechanisms promoting excretion. Sprague Dawley (SD) were induced by high purine diet (yeast pellets + adenine) for 5 weeks. Rats orally treated with SGF or...
Although age and parity are recognized as associated factors for adverse pregnancy outcomes, there no studies exploring the interaction between two during pregnancy. This study aimed to investigate impact of on outcomes.This was a retrospective cohort with 15,861 women aged ≥20 years. All were grouped according age, parity, mix two. The data analyzed using multivariate logistic regression analysis.Age, related risk gestational hypertension, eclampsia/pre-eclampsia, placenta previa, placental...
The present study aimed to determine the effects of polysaccharides-riched Prunus mume fruit juice concentrate (PFC) on uric acid (UA) excretion and gut microbiota in mice with chronic kidney disease (CKD). C57BL/6 were randomly allocated four groups: two that fed AIN93M diet, one which was administered 500 mg/kg PFC, diet containing 0.2% adenine, PFC. PFC promoted UA excretion, may have been mediated through increases protein expression ATP-binding cassette transporter G2 (ABCG2), organic...
Dihydromyricetin is the major flavonoid in vine tea, whose pharmacological action has attracted increasing attention recent years. The triglyceride, albumin (ALB), alanine aminotransferase, aspartate malondialdehyde, superoxide dismutase, glutathione (GSH), GSH peroxidase, tumor necrosis factor‑α, interleukin (IL)‑1β, IL‑6 and IL‑18 expression levels were measured using enzyme‑linked immunosorbent assay kits. protein of ALB collagen I, PPARα, NF‑κB, p53 Bax used to measure western blotting....
Abstract Emodinol, 1β,3β,23-trihydroxyolean-12-en-28-acid, as the main active ingredient firstly extracted from rhizomes of Elaeagus pungens by our research group, has been demonstrated to exhibit uricosuric activity previous study. The aim this study was evaluate and nephroprotective effects emodinol explore its possible mechanisms in potassium oxonate-induced hyperuricemic mice with renal dysfunction. Mice were orally administrated 250 mg/kg oxonate once daily for 7 consecutive days induce...
Combined aerobic and resistance training has been demonstrated to benefit glycemic control reverse nonalcoholic fatty liver disease in childhood obesity. General nonderepressible 2 (GCN2) deficiency reported attenuate hepatic steatosis insulin resistance. However, whether GCN2 impacts the positive effects of combined exercise remains unknown.To investigate improves glucose intolerance role plays mediating metabolic regulation exercise.Wild-type (WT) knockout (GCN2KO) mice were fed a high-fat...
Objective: This study aims to evaluate the effects of exercise training on heart function mice with diabetic cardiomyopathy. Materials and Methods: Twenty-four healthy C57 were randomly divided into three groups high-fat group (n = 8), control low-fat 8). High-fat fed a diet for 16 weeks, was subjected aerobic treadmill resistance 8 weeks. After 24 cardiac structure detected, indexes mouse analyzed compared. Results: The maintained hyperglycemia. results echocardiography showed that left...
Exercise preconditioning may protect against cardiac injury induced by lipopolysaccharide (LPS), but the mechanism is unresolved. The aim of this study to explore whether general control nonderepressible 2 (GCN2) kinase gene associated with protective effect exercise preconditioning. Eight-week-old male C57BL/6J (n = 40) and GCN2 knockout (KO) mice were divided into four groups: control, LPS (L), (E), (EL). Mice in groups performed for eight weeks. After exercise, all given an equal volume...
PURPOSE: Diabetic cardiomyopathy account for most of the diabetic death according to clinical data, and prevention treatment are still among challenging health problems today. To explore possible therapeutic intervention cardiomyopathy, a designed exercise training program was applied mice model with in this study, followed by systolic diastolic heart function measurement echocardiography. METHODS: Sixteen C57BL6 induced high fat glucose diet were divided randomly into group (Ex) control...
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