A5100324089- Hepatitis B Virus Studies
- Hormonal Regulation and Hypertension
- Hepatitis C virus research
- Medication Adherence and Compliance
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Pharmacological Effects and Toxicity Studies
- Glioma Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Pharmacy and Medical Practices
- Bipolar Disorder and Treatment
- Blood Pressure and Hypertension Studies
- Eicosanoids and Hypertension Pharmacology
- Biochemical and Molecular Research
- Connexins and lens biology
- Clostridium difficile and Clostridium perfringens research
- MicroRNA in disease regulation
- Retinal and Optic Conditions
- Renal Transplantation Outcomes and Treatments
- Histone Deacetylase Inhibitors Research
- Poisoning and overdose treatments
- Electronic Health Records Systems
- Inflammasome and immune disorders
- Cardiac Ischemia and Reperfusion
- Pharmaceutical Economics and Policy
- Vasculitis and related conditions
Huashan Hospital
2013-2024
Fudan University
2013-2024
Xiamen University
2022
// Wei Ding 1 , Honglei Guo 2 Chengyan Xu 3 Bin Wang Minmin Zhang and Feng Division of Nephrology, Shanghai Ninth People's Hospital, School Medicine, Jiaotong University, Shanghai, China The Fifth Hospital Fudan Huashan Institute Correspondence to: Zhang, email: Ding, Keywords : aldosterone, mitochondrial reactive oxygen species, NLRP3 inflammasome, renal tubular cells, chronic kidney disease, Pathology Section Received November 01, 2015 Accepted March 11, 2016 Published 21, Abstract...
Abstract Rationale, aims and objectives We aim to investigate a range of risk factors associated with medication adherence among C hinese hypertensive patients. also the association between blood pressure control. Methods A cross‐sectional study was conducted patients in comprehensive teaching hospital S hanghai, hina, using validated scale, self‐designed questionnaire patients' medical records. Results Of 232 eligible participants, 61 (26.3%), 51 (22.0%) 120 (51.7%) showed low, medium high...
Abstract Myocardial ischemia/reperfusion injury (MI/RI) is identified as a severe vascular emergency, and the treatment strategy of MI/RI still needs further improvement. The present study aimed to investigate potential effects mild therapeutic hypothermia (MTH) on underlying mechanisms. In (I/R) rats, MTH significantly improved myocardial injury, attenuated infarction, inhibited mitochondrial apoptosis pathway. results proteomics SLC25A10 main target treatment. Consistently, expressions in...
Background/Aim: Aldosterone (Aldo), a mediator of kidney fibrosis, is implicated in the pathogenesis chronic diseases (CKD). The aim this study was to evaluate regulatory role rapamycin (Rap) Aldo-induced tubulointerstitial inflammation and fibrosis. Methods: Uninephrectomized, Sprague-Dawley rats were given 1% NaCl (salt) drink randomized receive treatment for 28 days as follows: vehicle infusion (control), 0.75 μg/h Aldo subcutaneous infusion, or plus 1 mg/kg/day Rap by intraperitoneal...
We report a case of 19-year-old male who presented with bilateral Vogt-Koyanagi-Harada (VKH)-like panuveitis following an injection inactivated Covid-19 vaccine.A was referred to our clinic 2-week history blurred vision on both eyes and headaches, 12 hours the administration first dose virus vaccine (Sinovac). He denied any past ocular or medical history. Clinical examination multimodal imaging tests identified serous retinal detachment choroidal thickening posteriorly deep yellow foci in...
BACKGROUND:Reactive oxygen species (ROS) and inflammation both contribute to the progression of aldosterone-induced renal injury. To better understand underlying mechanisms, we examined mitochondrial dysfunction NLRP3 inflammasome activation in aldosterone-infused rats, explored role rotenone attenuating these injuries. MATERIAL AND METHODS:Sprague-Dawley rats were divided into 3 groups: vehicle-treated, aldosterone-infused, aldosterone plus rotenone. Renal damage was evaluated using PAS...
Background/Aims: Connexin43 (Cx43) belongs to a family of transmembrane proteins that build cell-to-cell channels in gap junctions, which play an essential role intercellular communication, cell proliferation, differentiation and apoptosis. The aim this study is clarify the effect Cx43 aldosterone (Aldo)-induced podocyte injury explore possible molecular mechanism behind effect. Methods: Uninephrectomized Sprague-Dawley rats were given 1% NaCl (salt) their water Aldo infusion (0.75 μg/h) for...
Oxidative stress has been implicated in the pathogenesis of chronic kidney disease (CKD) and antioxidants may ameliorate progression. We investigate beneficial effect Tempol, a superoxide dismutase-mimetic drug, on progression mouse model CKD.CKD was surgically induced c57BL/6 mice by 5/6 nephrectomy. Mice were randomly divided into 3 groups: sham group, nephrectomized group (Nx) Nx+Tempol (2 mmol/l drinking water). sacrificed at end 12 weeks. Renal function, structure as well expression key...
Abstract The heterogeneous molecular subtypes of gliomas demonstrate varied responses to chemotherapy and distinct prognostic outcomes. Gliomas with Isocitrate dehydrogenase 1 (IDH1) mutation are associated better outcomes more responsive temozolomide (TMZ) compared those without IDH1 mutation. IDH1-mutant elevate D-2-hydroxyglutarate (D-2HG) levels, potential dual effects on tumor progression. Limited research has explored the anti-glioma D-2HG in combination TMZ. Clinical data from over...
To evaluate Hy's law, DrILTox ALF Score, Robles-Diaz Model, and a new logistic regression model for predicting acute liver failure (ALF) in Chinese patients with drug-induced injury (DILI).
What is known and objective The frequent tenofovir disoproxil fumarate (TDF)-related adverse drug reactions (ADRs) are nephrotoxicity bone toxicity; however, tooth-related ADRs of TDF have not been reported. We describe the case a 41-year-old Han Chinese man with chronic hepatitis B TDF-associated tooth loss. Case summary He presented halitosis, gingival swelling loss after use. After excluding possibility other drug-related ADRs, was considered possible cause switched alafenamide (TAF). 6...
Telbivudine (LdT) is an antiviral agent currently used in the treatment of chronic hepatitis B virus, which was first approved by US FDA 2006. The safety LdT great importance for patients that receive long-term this condition. It has been confirmed treated with have significantly elevated creatine kinase levels. However, mechanism responsible adverse reaction unclear. This review summarizes current literature reactions and possible mechanisms are involved infection. Thus, we aim to provide...
Abstract Background Studies have found dysbiosis of the gut microbiota in hepatitis B virus (HBV)-infected individuals. Tenofovir dipivoxil (TDF) is one preferred oral antiviral drugs for treatment chronic (CHB), but effect TDF on and inflammatory factors remains unexplored. Methods In this study, we prospectively collected stool samples from unmedicated HBV patients CHB treated with TDF. Gut were studied 42 healthy subjects (HC group), 109 HBV-infected individuals, including 48 who did not...