A5100330940- Cell Adhesion Molecules Research
- Cancer Immunotherapy and Biomarkers
- Immune Response and Inflammation
- SARS-CoV-2 and COVID-19 Research
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- Immune cells in cancer
- Platelet Disorders and Treatments
- Cancer Cells and Metastasis
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- COVID-19 Clinical Research Studies
- Protease and Inhibitor Mechanisms
- Phagocytosis and Immune Regulation
- Viral gastroenteritis research and epidemiology
- Cellular Mechanics and Interactions
- Galectins and Cancer Biology
- Biochemical and Structural Characterization
- Glycosylation and Glycoproteins Research
- RNA and protein synthesis mechanisms
- Cancer Genomics and Diagnostics
- Influenza Virus Research Studies
- Extracellular vesicles in disease
- Wnt/β-catenin signaling in development and cancer
- RNA modifications and cancer
The University of Texas MD Anderson Cancer Center
2023-2025
Center for Excellence in Molecular Cell Science
2014-2024
Chinese Academy of Sciences
2013-2024
Harbin Medical University
2020-2024
Second Affiliated Hospital of Harbin Medical University
2020-2024
University of Chinese Academy of Sciences
2013-2024
Dalian Institute of Chemical Physics
2024
Dalian Medical University
2015-2024
First Affiliated Hospital of Dalian Medical University
2015-2024
China Three Gorges University
2010-2024
Rationale: Vascular calcification is a hallmark of atherosclerosis, major cause morbidity and mortality in the United States. We have previously reported that osteogenic transcription factor Runx2 an essential sufficient regulator vascular smooth muscle cells (VSMC) vitro. Objective: To determine contribution differentiation VSMC to pathogenesis function VSMC-derived regulating vivo. Methods Results: SMC-specific Runx2-deficient mice, generated by breeding SM22α-Cre mice with exon 8 floxed...
Background: Inflammation resolution and cardiac repair initiation after myocardial infarction (MI) require timely activation of reparative signals. Histone lactylation confers macrophage homeostatic gene expression signatures via transcriptional regulation. However, the role histone in response post-MI remains unclear. We aimed to investigate whether induces monocytes early remotely post-MI. Methods: Single-cell transcriptome data indicated that genes were activated bone marrow circulating...
Alterations of gut microbiota have been implicated in multiple diseases including cancer. However, the spectrum lung cancer remains largely unknown. Here we profiled composition a discovery cohort containing 42 early-stage patients and 65 healthy individuals through 16S ribosomal RNA (rRNA) gene sequencing analysis. We found that displayed significant shift contrast to populations. To identify optimal signature for noninvasive diagnosis purpose, took advantage Support-Vector Machine (SVM)...
Genetic variations in the ITGAM gene (encoding CD11b) strongly associate with risk for systemic lupus erythematosus (SLE). Here we have shown that 3 nonsynonymous variants produce defective CD11b elevated levels of type I interferon (IFN-I) lupus, suggesting a direct link between reduced activity and chronically increased inflammatory status patients. Treatment small-molecule agonist LA1 led to partial integrin activation, IFN-I responses WT but not CD11b-deficient mice, protected...
Activation of TGFB (transforming growth factor β) promotes liver fibrosis by activating hepatic stellate cells (HSCs), but the mechanisms activation are not clear. We investigated role ECM1 (extracellular matrix protein 1), which interacts with extracellular and structural proteins, in mouse livers.We performed studies C57BL/6J mice (controls), ECM1-knockout (ECM1-KO) mice, hepatocyte-specific knockout EMC1 (ECM1Δhep). or soluble TGFBR2 (TGFB receptor 2) were expressed livers after injection...
Macrophages are the key regulator of T-cell responses depending on their activation state. C-C motif chemokine receptor-like 2 (CCRL2), a nonsignaling atypical receptor originally cloned from LPS-activated macrophages, has recently been shown to regulate immune under several inflammatory conditions. However, whether CCRL2 influences macrophage function and regulates tumor immunity remains unknown. Here, we found that tumoral expression is predictive indicator robust antitumor in human...
Abstract Migrasomes are organelles that generated by migrating cells. Here we report the key role of neutrophil-derived migrasomes in haemostasis. We found a large number exist blood mice and humans. Compared with neutrophil cell bodies platelets, these adsorb enrich coagulation factors on surface. Moreover, they highly enriched adhesion molecules, which enable them to preferentially accumulate at sites injury, where trigger platelet activation clot formation. Depletion neutrophils, or...
The α subunit-inserted (I) domain of integrin αLβ2 [lymphocyte function-associated antigen-1 (LFA-1)] binds to intercellular adhesion molecule-1 (ICAM-1). C- and N-termini the I are near one another on "lower" face, opposite metal ion-dependent site (MIDAS) "upper face". In conversion open conformation, a 7 Å downward, axial displacement C-terminal helix α7 is allosterically linked rearrangement MIDAS into its high-affinity conformation. Here, we test hypothesis that when an applied force...
The lymphocyte homing receptor integrin α4β7 is unusual for its ability to mediate both rolling and firm adhesion. α4β1 are targeted by therapeutics approved multiple sclerosis Crohn’s disease. Here, we show electron microscopy crystallography how two therapeutic Fabs, a small molecule (RO0505376), mucosal adhesion molecule-1 (MAdCAM-1) bind α4β7. A long binding groove at the α4–β7 interface immunoglobulin superfamily domains differs in shape from pockets that Arg-Gly-Asp motifs. RO0505376...
Abstract Liver cirrhosis remains major health problem. Despite the progress in diagnosis of asymptomatic early-stage cirrhosis, prognostic biomarkers are needed to identify cirrhotic patients at high risk developing advanced stage disease. is result deregulated wound healing and featured by aberrant extracellular matrix (ECM) remodeling. However, it not comprehensively understood how ECM dynamically remodeled progressive development liver cirrhosis. It yet unknown whether signature...
Enzymes involved in collagen biosynthesis, including lysyl oxidase (LOX), have been proposed as potential therapeutic targets for idiopathic pulmonary fibrosis. LOX expression is significantly upregulated bleomycin (BLM)-induced lung fibrosis, and knockdown of or inhibition activity alleviates the Unexpectedly, treatment mice with inhibitor at inflammatory stage, but not fibrogenic efficiently reduces deposition normalizes architecture. Inhibition impairs cell infiltration, TGF-β signaling,...
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-associated liver disease with potentially deleterious consequences for the fetus, particularly when maternal serum bile-acid concentration >40 μM. However, etiology and pathogenesis ICP remain elusive. To reveal underlying molecular mechanisms association level fetal outcome in patients, DNA microarray was applied to characterize whole-genome expression profiles placentas from healthy women diagnosed ICP. Thirty pregnant recruited...
Study Design. A three-level rat tail caudal intervertebral disc (IVD) degeneration (IVDD) model was established to study effects of static compression on extracellular matrix (ECM) remodeling and integrin signaling in IVDs during IVDD. Objective. The aim this investigate the effect force ECM Summary Background Data. Integrins sense mechanical environment alteration via binding ligands trigger intracellular for pathological However, role IVDD remains elusive. Methods. Compared with classical...
Type IV collagens (Col IV), components of basement membrane, are essential in the maintenance tissue integrity and proper function. Alteration Col is related to developmental defects diseases, including cancer. α chains form α1α1α2, α3α4α5 α5α5α6 protomers that further collagen networks. Despite knowledge on functions major (α1α1α2), little known whether minor (α3α4α5 α5α5α6) plays a role It also remains be elucidated functionally redundant. We show α5 chain indispensable cancer development...