A5100377405- Cell Adhesion Molecules Research
- Cancer Immunotherapy and Biomarkers
- Cancer-related Molecular Pathways
- Gut microbiota and health
- Vibrio bacteria research studies
- Catalytic Cross-Coupling Reactions
- Immune cells in cancer
- Catalytic C–H Functionalization Methods
- Histone Deacetylase Inhibitors Research
- Neuroendocrine regulation and behavior
- Bioactive Compounds and Antitumor Agents
- Escherichia coli research studies
- Salmonella and Campylobacter epidemiology
- Advancements in Semiconductor Devices and Circuit Design
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Plant Virus Research Studies
- Immune Response and Inflammation
- Catalytic Alkyne Reactions
- Clostridium difficile and Clostridium perfringens research
- Liver Disease Diagnosis and Treatment
- Multiple Myeloma Research and Treatments
- Amoebic Infections and Treatments
- Protein Degradation and Inhibitors
- Ubiquitin and proteasome pathways
Centre for Addiction and Mental Health
2024-2025
Brigham and Women's Hospital
2019-2024
Medical University of South Carolina
2024
Harvard University
2019-2024
Howard Hughes Medical Institute
2020-2024
Beijing Luhe Hospital Affiliated to Capital Medical University
2024
Beijing Institute of Geology for Mineral Resources
2024
Mental Health Research Institute
2024
Ocean University of China
2023
Qingdao National Laboratory for Marine Science and Technology
2023
Accumulating evidence suggests the microbiota is a key factor in Disorders of Gut-Brain Interaction (DGBI), by affecting host immune and neural systems. However, underlying mechanisms remain elusive due to their complexity clinical heterogeneity patients with DGBIs. We aimed identify neuroimmune pathways that are critical microbiota-gut-brain communication during de novo gut colonization. employed combination gnotobiotic state-of-the-art microbial tools, behavioral analysis, pharmacological...
Transparent aluminum oxynitride ( AlON ) ceramics have been prepared through aqueous gelcasting forming technique starting from the raw materials of single phase powders. The powder was specially treated for anti‐hydrolysis in ethanol before shaping technique. surface‐treated powders could then be dispersed an aqueous‐organic solution to prepare stable slurries containing 35 vol% solids loading. obtained were subsequently casted, calcined, and pressureless sintered at 1950°C 8 h nitrogen...
Programmed cell death receptor 1 (PD-1) and its ligand PD-L1 are particularly interesting immune checkpoint proteins for human cancer treatment. Positron emission tomography (PET) imaging allows the dynamic monitoring of status during tumor progression, thus informing patients' response index. Herein, we report synthesis two linear peptide-based radiotracers, [64Cu]/[68Ga]HKP2201 [64Cu]/[68Ga]HKP2202, validate their utility visualization in preclinical models. The precursor peptide HKP2201...
Triptolide, a natural product derived from the Chinese plant Tripterygium wilfordii, is reported to exhibit antitumor effects in broad range of cancers. The activity triptolide associated with its biologic activities, as it inhibits various proproliferative or antiapoptotic factors that are dominantly expressed given types cancer cells. Herein, we show induced apoptosis subgroup acute lymphoblastic leukemia (ALL) cells overexpressing MDM2 oncoprotein by inhibiting expression. More...
Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy-associated liver disease with potentially deleterious consequences for the fetus, particularly when maternal serum bile-acid concentration >40 μM. However, etiology and pathogenesis ICP remain elusive. To reveal underlying molecular mechanisms association level fetal outcome in patients, DNA microarray was applied to characterize whole-genome expression profiles placentas from healthy women diagnosed ICP. Thirty pregnant recruited...
Intrahepatic cholestasis of pregnancy (ICP) is a cholestatic disorder with potentially deleterious consequences for fetuses. Although clear correlation between the elevated levels maternal serum bile acids and deficient fetal outcome has been established in clinical practice, underlying mechanisms remain elusive. Herein, we report that induce NF-κB pathway activation via G protein-coupled acid receptor 1 (Gpbar1), consequent upregulation inflammatory genes trophoblasts, leading to aberrant...
Abstract Enterovirus 71 (EV71) is the main causative agent of hand, foot and mouth disease (HFMD), which induces significantly elevated levels cytokines chemokines, leading to local or system inflammation severe complications, whereas underlying regulatory mechanisms inflammatory pathogenesis remain elusive. ARRDC4 one member arrestins family, having important roles in glucose metabolism G-protein-coupled receptors (GPCRs) related physiological pathological processes, however, function...
MSCs-based therapy for cancer is a relatively new but rapidly growing area of research.Human term placenta, an attractive source MSCs (PMSCs), appears to have great advantage due its easy access without invasive procedures, lack ethical issues and high-throughput young age.In the present study, we isolated from placenta characterized their morphology differentiation capacities.We next investigated underlying antitumor effects potential mechanism PMSCs express endostatin using adenoviral...
Immune cell infiltration is important for predicting the clinical outcomes of colorectal cancer. Integrin β7 (ITGB7), which expressed on surface leukocytes, plays an essential role in homing immune cells to gut-associated lymphoid tissue and facilitating retention lymphocytes gut epithelium; however, its cancer pathogenesis poorly explored. Here, we found that number β7+ decreased significantly tumor compared with adjacent normal tissue. expression tumor-derived tissue-derived CD8+ T cells....
Systemic infections can yield distinct outcomes in different tissues. In mice, intravenous inoculation of Escherichia coli leads to bacterial replication within liver abscesses, while other organs such as the spleen clear pathogen. Abscesses are macroscopic necrotic regions that comprise vast majority burden animal, yet little is known about processes underlying their formation. Here, we characterize E. abscesses and identify host determinants abscess susceptibility. Spatial transcriptomics...
Catalyst-controlled mono- and diolefinations of arenes <italic>via</italic> C–H activation in water with reaction times tens minutes.
A novel small-molecule anthraquinone (AQ) analogue, AQ-101, which was synthesized through chemical modification of the core structures rhein, exhibited potent anticancer activity. In present study, we evaluated cancer-inhibiting mechanism AQ-101 and tested therapeutic potential this compound for treating cancer in mice. We found that able to induce MDM2 protein degradation a self-ubiquitination proteasome-mediated mechanism. This AQ-101-induced downregulation led activation p53, contributed...
A radial p-n junction solar cell based on vertically free-standing silicon nanowire (SiNW) array is realized using a novel low-temperature and shallow phosphorus doping technique. The SiNW arrays with excellent light trapping property were fabricated by metal-assisted chemical etching process was carried out in hot wire vapor disposition chamber low substrate temperature of 250°C H2-diluted PH3 as the gas. Auger electron spectroscopy Hall effect measurements prove formation P atom surface...
It is known that the MDM2 protein stabilized when it forms a heterodimer with its partner MDM4, but stability in homodimer form not known. The contains C-terminal RING domain only functions as an E3 ligase to regulate ubiquitination of p53 and itself, also characterized be able bind several specific cellular mRNAs gene expression. In this study, we evaluate whether regulated by binding small RNA (XIAP IRES mRNA).We performed chemical cross-linking bimolecular fluorescence complementation...
Significance Here, a genome-scale CRISPR/Cas9 screen in epithelial cells using Salmonella , prototypical intracellular pathogen, led to the discovery of new role for IFN-I signaling. We found that this canonical antiviral signaling pathway controls subcellular localization, protein content, pH, and protease activity lysosomes. signaling-dependent lysosomal acidification was associated with heightened virulence gene expression escape into cytosol, vivo studies confirmed promoting systemic...
Palladium-catalyzed direct ethoxycarbonylation with diethyl azodicarboxylate was developed and its reaction mechanism explored by using DFT calculations.
To evaluate the efficacy and safety of intranasal insulin on postoperative cognitive dysfunction (POCD) in elderly patients after laparoscopic radical resection colorectal cancer.
A rhodium‐catalyzed ortho ‐cyanation protocol for 2‐aryl‐1,2,3‐triazole has been developed by using N ‐cyano‐ ‐phenyl‐ p ‐toluensulfonamide (NCTS) as an environmentally friendly cyanide source. This simple cyanation reaction provides a new the diversification of benzonitriles in moderate to good yields and tolerates useful functional groups. In addition, method was used synthesize 5‐methyl‐2‐(2 H ‐1,2,3‐triazol‐2‐yl)benzoic acid, which is key intermediate suvorexant.