A5112971486- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Immunotherapy and Immune Responses
- Influenza Virus Research Studies
- Animal Virus Infections Studies
- Insect Utilization and Effects
- Immune Cell Function and Interaction
- Monoclonal and Polyclonal Antibodies Research
- Insect symbiosis and bacterial influences
- Insect-Plant Interactions and Control
- Respiratory viral infections research
- Radiomics and Machine Learning in Medical Imaging
- Plant and Fungal Interactions Research
- MicroRNA in disease regulation
- AI in cancer detection
- Plant Disease Resistance and Genetics
- IL-33, ST2, and ILC Pathways
- Viral gastroenteritis research and epidemiology
- Insect behavior and control techniques
- Liver Disease Diagnosis and Treatment
- CRISPR and Genetic Engineering
- Digital Radiography and Breast Imaging
- Eosinophilic Esophagitis
- Medical Imaging and Analysis
- Entomopathogenic Microorganisms in Pest Control
Annoroad Gene Technology (China)
2025
Center for Excellence in Molecular Cell Science
2019-2025
University of Chinese Academy of Sciences
2018-2025
Sichuan Academy of Agricultural Sciences
2021-2025
Institute of Plant Protection
2021-2025
Sun Yat-sen Memorial Hospital
2020-2024
Sun Yat-sen University
2020-2024
ShenZhen People’s Hospital
2021-2024
Chinese Academy of Sciences
2019-2023
Jinan University
2023
Abstract Coronavirus disease 2019 (COVID-19), caused by the novel human coronavirus SARS-CoV-2, is currently a major threat to public health worldwide. The viral spike protein binds host receptor angiotensin-converting enzyme 2 (ACE2) via receptor-binding domain (RBD), and thus believed be target block entry. Both SARS-CoV-2 SARS-CoV share this mechanism. Here we functionally analyzed key amino acid residues located within binding motif of RBD that may interact with ACE2 available...
A facile solvent-free approach to prepare 2D nZVI/biochar with a shearing/carbonization method using lignocellulosic waste and FeCl<sub>3</sub>·6H<sub>2</sub>O as precursors.
Activation of TGFB (transforming growth factor β) promotes liver fibrosis by activating hepatic stellate cells (HSCs), but the mechanisms activation are not clear. We investigated role ECM1 (extracellular matrix protein 1), which interacts with extracellular and structural proteins, in mouse livers.We performed studies C57BL/6J mice (controls), ECM1-knockout (ECM1-KO) mice, hepatocyte-specific knockout EMC1 (ECM1Δhep). or soluble TGFBR2 (TGFB receptor 2) were expressed livers after injection...
Abstract Background The receptor-binding domain (RBD) variants of SARS-CoV-2 could impair antibody-mediated neutralization the virus by host immunity; thus, prospective surveillance antibody escape mutants and understanding evolution RBD are urgently needed. Methods Using single B cell cloning technology, we isolated characterized 93 RBD-specific antibodies from memory cells four COVID-19 convalescent individuals in early stage pandemic. Then, global alanine scanning with a panel 19 selected...
T-follicular helper (TFH) cells are a subset of CD4+ T that help germinal center (GC) B-cell differentiation and high-affinity antibody production during reactions. Whether important extracellular molecules control TFH is not fully understood. Here, we demonstrate secreted protein matrix 1 (ECM1) critical for response. A lack ECM1 inhibited cell development impaired GC reactions antigen-specific in an antigen-immunized mouse model. was induced by IL-6 IL-21 cells, promoting down-regulating...
Abstract Background Organisms have orchestrated coagulation and immune systems. Although a link between inflammation haemostasis has been reported in asthma, the interaction mechanism not completely elucidated. Here, we investigated direct mammalian Methods Mice were administered protease or antigens intranasally to induce airway with without thrombin inhibitors treatment. The effects of its on interleukin (IL)‐33 both vivo vitro. Peripheral blood mononuclear cells (PBMCs) plasma from asthma...
Insect gut microbes have important roles in host feeding, digestion, immunity, development, and coevolution with pests. The fall armyworm, Spodoptera frugiperda (Smith, 1797), is a major migratory agricultural pest worldwide. effects of plant on the pest’s bacteria remain to be investigated better understand their coevolution. In this study, differences bacterial communities were examined for fifth sixth instar larvae S. fed leaves different plants (corn, sorghum, highland barley, citrus)....
Abstract Most structurally characterized broadly neutralizing antibodies (bnAbs) against influenza A viruses (IAVs) target the conserved conformational epitopes of hemagglutinin (HA). Here, we report a lineage naturally occurring human sharing same germline gene, V H 3-48/V K 1-12. These neutralize major circulating strains IAV in vitro and vivo mainly by binding contiguous epitope H3N2 HA, but H1N1 respectively. Our structural functional studies antibody 28-12 revealed that continuous amino...
Modulation or depletion of tumor-infiltrating Tregs (Ti-Tregs) is a promising strategy in the field antitumor immunotherapy. However, this approach poses challenges due to diversity within Treg population and lack precision targeting Ti-Tregs. To selectively efficiently eliminate Ti-Tregs while sparing other immune cells, we developed bispecific antibody, FT10-Fab, TNFR2 CCR8, which are highly expressed on Our results showed that FT10-Fab outperformed monotherapies several tumor models by...
ABSTRACT Gut microbiota crucially affects metabolism and health. Hycleus cichorii Linnaeus has been listed as a medicinal insect in the Pharmacopeia of People's Republic China due to presence cantharidin, which curative effect on many cancers skin diseases. In order analyze effects dietary habits gender diversity composition gut H. provide basis for an artificial diet, this study, full‐length 16S rRNA sequencing technology was used 35 adults, including wild female adults (WFA), male (WMA),...
Background and Aims: Extracellular matrix protein 1 (ECM1) is known to inhibit transforming growth factor β (TGF-β) signalling hepatic stellate cells (HSCs) activation, thereby attenuating liver fibrosis. RNA-seq profiling of livers from wild-type (WT) Ecm1-deficient mice revealed different enrichments in metabolic changes fatty acid synthesis inflammatory pathways, suggesting a regulatory role for ECM1 steatosis. Here, we studied the dysfunction-associated steatotic disease (MASLD)...
Abstract Three prevalent SARS-CoV-2 variants of concern (VOCs) emerged and caused epidemic waves. It is essential to uncover advantageous mutations that cause the high transmissibility VOCs. However, viral are tightly linked, so traditional population genetic methods, including machine learning–based cannot reliably detect conferring a fitness advantage. In this study, we developed an approach based on sequential occurrence order accelerated furcation rate in pandemic-scale phylogenomic...
Induction of broadly neutralizing monoclonal antibodies (bNAbs) that bind to the viral envelope glycoproteins is a major goal hepatitis C virus (HCV) vaccine research. The study bNAbs arising in natural infection essential this endeavor. We generated human antibody, 8D6, recognizing E2 protein HCV isolated from chronic patient. This antibody shows activity, which covers pan-genotypic panel cell culture-derived virions (HCVcc). Functional and epitope analyses demonstrated 8D6 can block...
Geographic isolation is an important factor that limit species dispersal and thereby affects genetic diversity. Because islands are often small surrounded by a natural water barrier to dispersal, they generally form discrete isolated habitats. Therefore, may play key role in the distribution of diversity insects, including flies. To characterize structure island populations Bactrocera dorsalis, we analyzed dataset containing both microsatellite mtDNA loci B. dorsalis samples collected from...
The Mulibrey (Muscle-liver-brain-eye) nanism caused by loss-of-function variants in TRIM37 gene is an autosomal recessive disorder characterized severe growth failure and constrictive pericarditis. These patients also suffer from respiratory infections, co-incident with increased mortality rate. Here, we revealed that were associated recurrent infection. Trim37 FINmajor (a representative variant of patients) knockout mice susceptible to influenza virus showed defects follicular helper T...