Macrophages are the key regulator of T-cell responses depending on their activation state. C-C motif chemokine receptor-like 2 (CCRL2), a nonsignaling atypical receptor originally cloned from LPS-activated macrophages, has recently been shown to regulate immune under several inflammatory conditions. However, whether CCRL2 influences macrophage function and regulates tumor immunity remains unknown. Here, we found that tumoral expression is predictive indicator robust antitumor in human...

There is mounting evidence that T helper (Th)17 cells and regulatory (Treg) play parts in the pathogenesis of autoimmune disease. Hence, levels these T-cell subsets patients with alopecia areata (AA) merit investigation. Our goal was to assess Th17 Treg peripheral blood mononuclear (PBMC) scalp lesions AA, correlating findings clinical characteristics. PBMC 177 AA (test group) 42 healthy controls tissues 33 15 were collected. Levels then determined via flow cytometry immunohistochemical...

Trichoscopy is a novel tool for the diagnosis of hair loss disorders such as androgenetic alopecia (AGA), but there are still few reports on association between trichoscopic findings and disease severity, especially in Chinese population. A case-control observational study was conducted to observe AGA evaluate their relationship with severity. Trichoscopic examination performed handheld dermoscope 750 male (MAGA) 200 female (FAGA) patients, along 100 50 normal controls. Trichoscopically,...

Finasteride at 1 mg/day and 5% topical minoxidil are effective in male androgenetic alopecia (MAGA). However, studies describing their effects Chinese individuals scarce. 450 MAGA patients were randomly assigned to receive finasteride (n = 160), 130) combined medication 160) for 12 months. The returned the clinic every 3 months efficacy evaluation. And was evaluated 428 men treatment end, including 154, 122, 152 finasteride, minoxidil, combination groups, respectively. All groups showed...

Diabetic retinopathy (DR) remains the leading cause of blindness in adults with diabetes mellitus. Numerous microRNAs (miRNAs) have been identified to modulate pathogenesis DR. The main purpose this study was evaluate potential roles miR-455-5p high glucose (HG)-treated retinal pigment epithelial (RPE) cells and underlying mechanisms. Our present investigation discovered that expression apparently downregulated ARPE-19 stimulated HG. In addition, forced markedly enhanced cell viability...

Diabetic cardiomyopathy (DCM) is a common heart disease. The Phase II enzyme inducer (CPDT) complex that promotes the expression of antioxidant enzymes through activating nuclear factor erythroid 2-related 2 (Nrf2); these compounds have been shown to protect against oxidative stress. However, whether similar protective effects in DCM still remains unclear. purpose this study investigate and potential mechanism CPDT diabetic cardiomyopathy. In results, firstly, compared with control rats,...

Abstract Background Although bilirubin has been generally regarded as a waste with potential neurotoxicity at high levels, few clinical studies suggest protective role of physiological serum total (TBIL) concentrations in diabetic peripheral neuropathy (DPN). However, the pathological mechanisms underlying relationship remain poorly understood. The objective this study was to explore between TBIL and DPN, laboratory parameters. Methods Serum measured 1342 patients type 2 diabetes mellitus...

Objective To compare prospective ECG-gated multi-slice computed tomography (MSCT) and trans-thoracic echocardiography (TTE) in the diagnosis of complex congenital heart disease (CHD). Methods This was a study consecutive patients with CHD (age <7 years) treated at tertiary hospital between May 2013 2015. All were imaged TTE 128-slice spiral CT week before surgery. Effective radiation dose (ED) calculated from volume index (CTDIvol) length product (DLP). Image quality (5-point scale) assessed...

Abstract Background Alopecia areata (AA) is a common inflammatory disease characterized by cellular infiltration of T cells targeting the anagen‐stage hair follicle. Lack efficacious treatment for AA may be due to little knowledge about its exact mechanism. Studies have demonstrated that microRNAs (miRNAs) play an important role in regulation skin diseases such as atopic dermatitis and psoriasis. However, known miRNAs AA. Objective The present study aimed explore blood alterations patients...

Despite previous research that focused on aspartate aminotransferase/alanine aminotransferase ratio (AAR) as predictors of type 2 diabetes mellitus (T2DM) and cardiovascular disease, there has been limited evaluating the association between AAR diabetic microvascular complications. This study aimed to investigate with peripheral neuropathy (DPN). A total 1562 hospitalized patients T2DM were divided into four groups according quartiles. The relationship DPN related parameters was explored by...

Abstract Background It has been suggested that low vitamin D levels may affect the development of hair loss. Aims Our aim was to evaluate serum 25‐hydroxy [25(OH)D] status in Chinese patients with alopecia areata (AA), female pattern loss (FPHL), and male androgenetic (MAGA) compared healthy individuals. Methods We performed a case‐control study including 443 AA patients, 657 FPHL 777 MAGA 2070 normal controls (1064 1006 individuals) from 2015 2017 analyze correlation 25(OH)D population....

Abstract Background Previous studies that explored the relationship of serum albumin with diabetic peripheral neuropathy (DPN) have indicated inconsistent results. Thus, present study aimed to evaluated association between and DPN, defined as vibration perception threshold (VPT) values ≥ 25 V and/or inability feel monofilament, in Chinese patients type 2 diabetes mellitus (T2DM). Methods 1465 T2DM aged 16 years, who completed measurement DPN screening 2012 2015, were included cross-sectional...

Interleukin-2 receptor subunit alpha (IL2RA) is highly expressed on CD4+CD25+ regulatory T cells and important for immune homeostasis the suppression of autoimmune responses. It has been suggested that single nucleotide polymorphism in IL2RA may affect pathogenesis alopecia areata (AA).Our aim was to investigate link between AA a Chinese population.We examined 427 patients 430 controls this study. The rs3118470 evaluated using high-resolution melting analysis direct sequencing.The prevalence...

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; It has been suggested that the single nucleotide polymorphism (SNP) of CYP19A1 gene encoding aromatase may affect development female pattern hair loss (FPHL). &lt;b&gt;&lt;i&gt;Objective:&lt;/i&gt;&lt;/b&gt; Our aim was to investigate association SNPs with FPHL in a Chinese population. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; Two hundred Han patients and 200 controls were enrolled into our study. SNaPshot technology used detect...

Abstract Background Limited studies regarding the correlation of lipid accumulation product (LAP) with a decreased estimated glomerular filtration rate (eGFR) have yielded conflicting findings, and no report has demonstrated relationship LAP chronic kidney disease (CKD), defined as presence albuminuria and/or eGFR. The purpose this study was to estimate possible CKD prevalence in Chinese community adults. Method In cross-sectional study, level 7202 participants (age ≥ 40 years) determined,...

Omentin-1, a newly identified adipokine, has been demonstrated to be associated with bone metabolism, but the results have inconsistent. Moreover, potential relationship of circulating omentin-1 diabetic osteoporosis never reported. This study is intended for studying association between omentin-1, mineral density (BMD), prior fragility fractures, and other metabolic-related parameters.Circulating levels were measured in 172 patients type 2 diabetes mellitus (T2DM), participants divided into...

Neuregulin 4 (Nrg4) is a novel neurotrophic adipokine associated with the development of diabetic peripheral neuropathy (DPN), however, pathological mechanism remains poorly understood. The purpose our study was to investigate association circulating Nrg4 DPN and 25-hydroxy vitamin D [25(OH)D], multifunctional secosteroid hormone that regulates other factors adipokines gene expression, vascular complications.Circulating levels were measured an ELISA kit in 164 newly diagnosed type 2 diabetes...

To investigate the association of CAG repeat numbers in androgen receptor (AR) gene with female pattern hair loss (FPHL) a Chinese population.A total 200 Han patients FPHL (142 Ludwig II and 58 III cases) healthy controls were enrolled this study. The polymorphism was analyzed by fluorescent amplified fragment length technique.The biallelic mean 23.73 ± 2.04 repeats 23.90 2.13 controls, without any significant difference between two groups (p = 0.481). In addition, neither shorter nor longer...

Abstract The available interventions for androgenic alopecia (AGA), the most common type of hair loss worldwide, remain limited. insulin growth factor (IGF) system may play an important role in pathogenesis AGA. However, exact IGF binding protein‐related protein 1 (IGFBP‐rP1) and AGA has not been reported. In this study, we first found periodic variation IGFBP‐rP1 during cycle transition murine follicles (HFs). We further demonstrated that levels were lower serum scalp HFs individuals with...

Cardiovascular disease which is associated with cardiac dysfunction, usually measured circulating levels of B-type natriuretic peptide (BNP), has been incidence and progression diabetic peripheral neuropathy (DPN). The potential relationship physiological BNP DPN, however, not reported. Circulating were in 258 patients type 2 diabetes mellitus (T2DM), participants divided into a DPN group ( <a:math xmlns:a="http://www.w3.org/1998/Math/MathML" id="M1"> <a:mi>n</a:mi> <a:mo>=</a:mo>...