A5008550424- Cardiac Fibrosis and Remodeling
- Acute Myocardial Infarction Research
- Cardiac Imaging and Diagnostics
- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Coronary Interventions and Diagnostics
- Hormonal Regulation and Hypertension
- Heat shock proteins research
- Congenital heart defects research
- Coal Properties and Utilization
- Cardiac Structural Anomalies and Repair
- Atrial Fibrillation Management and Outcomes
- MicroRNA in disease regulation
- Macrophage Migration Inhibitory Factor
- Eicosanoids and Hypertension Pharmacology
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac electrophysiology and arrhythmias
- Metabolomics and Mass Spectrometry Studies
- Signaling Pathways in Disease
- Coronary Artery Anomalies
- Circular RNAs in diseases
- Scoliosis diagnosis and treatment
- Inflammasome and immune disorders
- Adenosine and Purinergic Signaling
Qingdao University
2023-2024
Qingdao Municipal Hospital
2024
Shanghai East Hospital
2017-2023
Chongqing Medical University
2023
Shanghai Jiao Tong University
2022-2023
Second Affiliated Hospital of Chongqing Medical University
2023
Shanxi Medical University
2023
Dalian Medical University
2023
Taiyuan University of Technology
2022
Tongji University
2022
Background Recent studies have emphasized causative links between microRNAs (miRNAs) deregulation and tumor development. In hepatocellular carcinoma (HCC), more miRNAs were identified as diagnostic prognostic cancer biomarkers, well additional therapeutic tools. This study aimed to investigate the functional significance regulatory mechanism of miR-199a2/214 cluster in HCC progression. Methods Findings this study, we showed that miR-214, miR-199a-3p miR-199a-5p levels significantly reduced...
Prolonged endoplasmic reticulum (ER) stress causes apoptosis and is associated with heart failure. Whether CYP2J2 its arachidonic acid metabolites [epoxyeicosatrienoic acids (EETs)] have a protective influence on ER failure has not been studied. Assays of myocardial samples from patients end-stage showed evidence stress. Chronic infusion isoproterenol (ISO) or angiotensin II (AngII) by osmotic mini-pump induced cardiac hypertrophy in mice as evaluated hemodynamic measurements...
Background and Purpose Inhibition of the cGMP‐specific phosphodiesterase 5 ( PDE5 ) exerts profound beneficial effects on failing hearts. However, mechanisms underlying therapeutic inhibition heart failure are unclear. The purpose this study was to investigate whether decreases endoplasmic reticulum ER stress, a key event in failure. Experimental Approach Heart induced by isoprenaline s.c. injection S prague– D awley rats transverse aortic constriction TAC mice. inhibited with sildenafil....
We aimed to investigate the predictors and prognosis of left ventricular thrombus (LVT) in patients admitted for post-myocardial infarction (MI) dysfunction after contemporary percutaneous coronary intervention (PCI).We prospectively enrolled 267 consecutive post-MI with ejection fraction (LVEF) <0.45 based on Shanghai East Hospital PCI database since 2012. Altogether 25 (9.36%) were selected as LVT group. Baseline, angiographic, procedural characteristics 1-year clinical outcomes compared...
Fibrotic cardiac muscle exhibits high stiffness and low compliance which are major risk factors of heart failure. Although heat shock transcription factor 1 (HSF1) was identified as an intrinsic cardioprotective factor, the role that HSF1 plays in fibrosis remains unclear. Our study aims to investigate pressure overload-induced underlying mechanism. phosphorylation significantly downregulated transverse aortic constriction (TAC)-treated mouse hearts mechanically stretched fibroblasts (cFBs)....
Primary percutaneous coronary intervention (PCI) has been the standard reperfusion strategy for patients with acute myocardial infarction (AMI) in contemporary era. Meanwhile, incidence and prognosis of left ventricular aneurysm (LVA) AMI remain ambiguous. The aim current study is to identify predictor long-term LVA anterior infarction.
A comprehensive view of the role NLRP3/caspase-1/GSDMD-mediated pyroptosis in pressure overload cardiac hypertrophy is presented this study. Furthermore, mitigation NLRP3 deficiency-induced confers cardioprotection against through activation TAK1, whereas salutary effect abolished by inhibition TAK1 activity, highlighting a previously unrecognized reciprocally regulatory NLRP3-TAK1 governing inflammation-induced cell death and hypertrophic growth. Translationally, study advocates strategies...
Cardiac hypertrophy after myocardial infarction (MI) is an independent risk factor for heart failure. Regression of cardiac has emerged as a promising strategy in the treatment MI patients. Here, we have been suggested that heat-shock transcription 1 (HSF1) novel repressor ischaemia-induced hypertrophy. Ligation left anterior descending coronary was used to produce HSF1-deficient heterozygote (KO), HSF1 transgenic (TG) mice and their wild-type (WT) littermates, respectively. Neonatal rat...
Abstract Background Dual antiplatelet therapy (DAPT) with aspirin and a P2Y12 receptor inhibitor has become the standard of care to reduce thrombotic events in patients acute coronary syndrome or after percutaneous intervention (PCI). The role routine platelet function testing (PFT) treated DAPT PCI remains controversial evidence PFT‐guided for ST‐segment elevation myocardial infarction (STEMI) undergoing primary is limited. Methods We analyzed 1,353 consecutive STEMI PCI. PFT was performed...
Ryanodine receptor type 2 (RyR-2), the main Ca2+ release channel from sarcoplasmic reticulum in cardiomyocytes, plays a vital role regulation ofmyocardial contractile function and cardiac hypertrophy. However, of RyR-2 fibrosis during development hypertrophy remains unclear.In this study, we examined whether regulates TGFβ1, which is secreted cardiomyocytes exerts on using cultured fibroblasts neonatal rats. The expression was found only cardiomyocytesbut not fibroblasts. Mechanical stretch...
We previously showed that Qiliqiangxin (QL) capsules could ameliorate cardiac hypertrophy and remodeling in a mouse model of pressure overload. Here, we compared the effects QL alone with those combined following 3 types antihypertensive drugs on dysfunction induced by overload for 4 weeks mice: an angiotensin II type 1 receptor (AT1-R) blocker (ARB), angiotensin-converting enzyme inhibitor (ACEI), β-adrenergic (β-AR) (BB). Adult male mice (C57B/L6) were subjected to either transverse aortic...
By employing a proteomic analysis on supernatant of mechanically stretched cardiomyocytes, we found that stretch induced significantly high level β-2 microglobulin (β2M), non-glycosylated protein, which is related to inflammatory diseases but rarely known in cardiovascular diseases. The present data showed serum β2M was increased patients with hypertension and further chronic heart failure (HF) as compared control group, the correlated cardiac dysfunction these patients. In pressure overload...
The clinical goal of cell-based treatment for chronic heart failure is to coordinately reconstitute the cardiomyocytes and associated circulation environment including coronary resistance arteries, arterioles, capillary profiles.(1)) This can be possibly achieved by implementing multipotent adult stem cells. However, it remains a challenge modify network in decompensated heart. A mechanical stress model was used this study mimic hemodynamic hormonal states vitro. angiogenesis role...
In mice, myocardial hypertrophic preconditioning (HP), which is produced by the removal of short-term transverse aortic constriction (TAC), was recently reported to render heart resistant responses induced subsequent reconstriction (Re-TAC). However, there no efficient noninvasive method for ensuring that repeated manipulations were successfully performed. We previously demonstrated ultrasound biomicroscopy (UBM) a and effective approach predicting TAC success. Here, we investigated value...
Coronary artery aneurysm (CAA) and coronary ectasia (CAE) may be two different types of dilatation with unknown etiology. This study aimed to compare the differences between CAA CAE investigate their pathogenesis necessity antiplatelet therapy.One hundred patients each confirmed CAA, CAE, normal (NCA) from September 2017 July 2019 were included. All completed examinations ankle-brachial index (ABI), pulse wave rate, carotid ultrasonography; tested for routine blood, lipid, immune parameters....
Acetaldehyde is one of the crucial gases with odor released during early stage spontaneous combustion coal, and it essential for predicting tendency coal. In this study, we systematically investigated effects coal metamorphic degree, temperature, particle size, oxygen concentration on release acetaldehyde using three samples different degrees a combination oxidation warming processes as well gas liquid chromatography. The results showed that increase in amount first increased then stabilized...
The threshold dilution ratio of acetaldehyde is much larger than those other odor compounds generated during the spontaneous combustion process and so it most important odorant. Studying mechanism by which can provide necessary theoretical support for acetaldehyde-based analysis. In present work, release was monitored while heating lignite, long-flame coal, coking coal specimens under either air or nitrogen. data show that primarily produced oxidation active sites in rather pyrolysis...
In general, an advanced control strategy is necessary for electro-hydraulic servo system to obtain fast and accurate response. A novel scheme called PID sliding mode was proposed by combining conventional strategy. The linear dynamic of established precisely. law deduced in detail. chattering problem caused original weakened a continuous algorithm. simulation results demonstrated the effectiveness method.
This study sought to investigate the dynamic functional changes of coronary intermediate lesions using quantitative flow ratio (QFR) and its implication on long-term clinical outcomes. Physiology-guided percutaneous intervention in patients with angiographic has been associated favorable consecutively enrolled 1130 deferred at baseline angiography subsequently received second-time between 9 months 2 years later from two centers China. The follow-up (ΔQFR) were defined as (baseline...
Aortic regurgitation (AR) is a common valvular heart disease that exerts volume overload on the and represents global public health problem. Although mice are widely applied to shed light mechanisms of cardiovascular disease, mouse models AR, especially those induced by surgery, still paucity. Here, model AR was described in detail which surgically disruption aortic valves under high-resolution echocardiography. In accordance with regurgitated blood flow, hearts present distinctive...
Based on former combination synchronization studies, a new type of approach is developed in this research, with the consideration parallel drive systems. This referred to as synchronization‐II. As representative case, synchronization‐II between three systems and one response system studied. Applying Lyapunov stability theorem active backstepping design, sufficient conditions for proposed are derived. Numerical simulations performed show feasibility effectiveness approach. investigation...