A5101456506- Cardiovascular Function and Risk Factors
- Atherosclerosis and Cardiovascular Diseases
- Cardiac Fibrosis and Remodeling
- Mesenchymal stem cell research
- Coronary Interventions and Diagnostics
- Lipoproteins and Cardiovascular Health
- Tissue Engineering and Regenerative Medicine
- MicroRNA in disease regulation
- Inflammasome and immune disorders
- Antiplatelet Therapy and Cardiovascular Diseases
- Mitochondrial Function and Pathology
- Adipose Tissue and Metabolism
- Autophagy in Disease and Therapy
- Cardiac Ischemia and Reperfusion
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Heart Failure Treatment and Management
- RNA modifications and cancer
- Circular RNAs in diseases
- Signaling Pathways in Disease
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Adipokines, Inflammation, and Metabolic Diseases
- Peroxisome Proliferator-Activated Receptors
- Cholesterol and Lipid Metabolism
Zhongshan Hospital
2016-2025
Fudan University
2016-2025
Second People’s Hospital of Huai’an
2023-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2025
Peking Union Medical College Hospital
2013-2025
Ruijin Hospital
2004-2025
Shanghai Institute of Hypertension
2004-2025
Shanghai Jiao Tong University
2025
Xuzhou Medical College
2023-2025
Sun Yat-sen University
2015-2024
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PCSK9 (proprotein convertase subtilisin/kexin 9), mainly secreted by the liver and released into blood, elevates plasma low-density lipoprotein cholesterol degrading receptor. Pleiotropic effects of beyond lipid metabolism have been shown. However, direct on platelet activation thrombosis, underlying mechanisms, as well, still remain unclear.We detected agonist-induced aggregation, dense granule ATP release, integrin αIIbβ3 activation, α-granule spreading, clot retraction. These studies were...
Rationale: Excessive myocardial fibrosis is the main pathological process in development of cardiac remodeling and heart failure; therefore, it important to prevent excessive fibrosis. We determined that microRNA-378 (miR-378) cardiac-enriched highly repressed during remodeling. therefore proposed miR-378 has a critical role regulation fibrosis, examined effects on after mechanical stress. Methods: Mechanical stress was respectively imposed mice through transverse aortic constriction (TAC)...
Myocardial infarction (MI) dampens heart function and poses a great health risk. The class III deacetylase sirtuin 1 (SIRT1) is known to confer cardioprotection. SIRT1 expression downregulated in the by number of stress stimuli that collectively drive pathogenesis MI, although underlying mechanism remains largely obscure. Here we show primary rat neonatal ventricular myocytes (NRVMs), ischaemic or oxidative leads rapid upregulation SUV39H, mammalian histone H3K9 methyltransferase,...
Background: Excessive accumulation of reactive oxygen species (ROS), catalyzed by the NADPH oxidases (NOX), is involved in pathogenesis ischemia-reperfusion (IR) injury. The underlying epigenetic mechanism remains elusive. Methods: We evaluated potential role megakaryocytic leukemia 1 (MKL1), as a bridge linking activation NOX to ROS production and cardiac Results: Following IR injury, MKL1-deficient (knockout) mice exhibited smaller myocardial infarction along with improved heart function...
Abstract Cardiac fibroblasts (CFs) are the primary cells tasked with depositing and remodeling collagen significantly associated heart failure (HF). TEAD1 has been shown to be essential for development homeostasis. However, fibroblast endogenous in cardiac remains incompletely understood. Transcriptomic analyses revealed consistently upregulated expression mice 4 weeks after transverse aortic constriction (TAC) Ang-II infusion. Further investigation that CFs were cell type expressing...
Both advanced glycosylation end products (AGEs) and dendritic cells (DCs) have been shown to play a causative role in atherosclerosis. However, whether they function interactively the process remains uncertain. We therefore studied effects of AGE-bovine serum albumin (AGE-BSA) on maturation DCs expressions scavenger receptor-A (SR-A) receptor for AGEs (RAGE) DCs.AGE-BSA induced accompanied with increased CD1a, CD40, CD80, CD83, CD86, MHC class II. The capacity stimulate T-cell proliferation...
Oxidized LDL (ox-LDL) activates dendritic cells (DCs), thereby initiating inflammation responses in atherosclerosis, yet the modulatory mechanisms remain unclear. MicroRNAs (miRNAs) are important regulators for DC functions. This study evaluated regulation by miRNAs of ox-LDL-induced immune response. In CD11c(+) DCs from ApoE-deficient mice with hyperlipidemia, microRNA miR-181a was significantly up-regulated. cultured bone marrow-derived (BMDCs), ox-LDL promoted maturation and up-regulated...
Objective. Anesthesia provides sedation and immobility, facilitating echocardiography in mice, but it influences cardiovascular function therefore outcomes of measurement. This study aimed to determine the effect optimal heart rate (HR) anesthetic timing on echocardiographic reproducibility under isoflurane anesthesia. Methods. Male C57BL/6J mice underwent high-resolution with relative fixed HRs timing. The same experiment was repeated once again after 1 week. Results. Echocardiography...
The immune inflammatory response plays a crucial role in many cardiac pathophysiological processes, including ischaemic injury and the post-infarction repair process. MicroRNAs (miRNAs) regulate development function of dendritic cells (DCs), which are key players initiation regulation responses; however, underlying regulatory mechanisms remain unclear. Here, we used supernatants necrotic primary cardiomyocytes (Necrotic-S) to mimic myocardial infarction (MI) microenvironment investigate...
Abstract The role of M1 macrophages (M1M)-derived exosomes in the progression neointimal hyperplasia remains unclear now. Using a transwell co-culture system, we demonstrated that M1M contributed to functional change vascular smooth muscle cell (VSMC). We further stimulated VSMCs with isolated from M1M. Our results these could be taken up by through macropinocytosis. microRNA array assay, identified miR-222 originated M1M-derived triggered changes VSMCs. In addition, confirmed played key...
To evaluate the clinical efficacy and safety of α-Lipoic acid (ALA) for critically ill patients with coronavirus disease 2019 (COVID-19).A randomized, single-blind, group sequential, active-controlled trial was performed at JinYinTan Hospital, Wuhan, China. Between February 2020 March 2020, 17 COVID-19 were enrolled in our study. Eligible randomly assigned a 1:1 ratio to receive either ALA (1200 mg/d, intravenous infusion) once daily plus standard care or equal volume saline infusion...
Abstract Cardiomyocyte pyroptosis and apoptosis play a vital role in the pathophysiology of several cardiovascular diseases. Our recent study revealed that gasdermin D (GSDMD) can promote myocardial I/R injury via caspase-11/GSDMD pathway. We also found GSDMD deletion attenuated MI by reducing cardiomyocyte pyroptosis. However, how mediates protects function remains unclear. Here, we doxorubicin (DOX) treatment resulted increased cardiomyocytes could mediate DOX-induced cardiotoxicity (DIC)...
N6-methyladenosine (m6A) methylation produces a marked effect on cardiovascular diseases. The m6A demethylase AlkB homolog 5 (ALKBH5), as an "eraser", is responsible for decreased modification. However, its role in cardiac fibroblasts during the post-myocardial infarction (MI) healing process remains elusive.
Abstract Rho‐associated kinase ( ROCK ) plays a critical role in pressure overload‐induced left ventricular remodelling. However, the underlying mechanism remains unclear. Here, we reported that TGF ‐β1‐induced elevation suppressed BMP ‐2 level and strengthened fibrotic response. Exogenous supply effectively attenuated ‐β1 signalling pathway through S mad6‐ murf‐1 complex activation. In vitro cultured cardiomyocytes, mechanical stretch up‐regulated cardiac ‐β1, ‐β1‐dependent down‐regulated...
Ryanodine receptor type 2 (RyR-2) mediates Ca(2+) release from sarcoplasmic reticulum and contributes to myocardial contractile function. However, the role of RyR-2 in development cardiac hypertrophy is not completely understood. Here, mice with or without reduction gene (RyR-2(+/-) wild-type, respectively) were analyzed. At baseline, there was no difference morphology cardiomyocyte heart contractility between RyR-2(+/-) wild-type mice, although impaired isolated cardiomyocytes. During a...