A5039601252- Ubiquitin and proteasome pathways
- Remote-Sensing Image Classification
- Remote Sensing and Land Use
- Autophagy in Disease and Therapy
- Remote Sensing in Agriculture
- Cancer-related Molecular Pathways
- Advanced Image Fusion Techniques
- Liquid Crystal Research Advancements
- RNA modifications and cancer
- Advanced optical system design
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related gene regulation
- Glycosylation and Glycoproteins Research
- Synthesis and properties of polymers
- Image and Signal Denoising Methods
- Cancer, Hypoxia, and Metabolism
- Protein Degradation and Inhibitors
- Coronary Interventions and Diagnostics
- Viral Infectious Diseases and Gene Expression in Insects
- Peptidase Inhibition and Analysis
- Calibration and Measurement Techniques
- Spectroscopy and Chemometric Analyses
- Extracellular vesicles in disease
- Geochemistry and Geologic Mapping
- NF-κB Signaling Pathways
Zhejiang University
2016-2025
First Affiliated Hospital Zhejiang University
2016-2025
Aerospace Information Research Institute
2020-2025
Chinese Academy of Sciences
2014-2025
University of Chinese Academy of Sciences
2017-2025
Zunyi Medical University
2021-2025
Xinxiang Medical University
2024-2025
Xian Yang Central Hospital
2025
Wuhu No 1 People's Hospital
2025
Fudan University
2020-2024
We have produced the first 30 m resolution global land-cover maps using Landsat Thematic Mapper (TM) and Enhanced Plus (ETM+) data. classified over 6600 scenes of TM data after 2006, 2300 ETM+ before all selected from green season. These images cover most world's land surface except Antarctica Greenland. Most these came United States Geological Survey in level L1T (orthorectified). Four classifiers that were freely available employed, including conventional maximum likelihood classifier...
Validating land-cover maps at the global scale is a significant challenge. We built validation data-set based on interpreting Landsat Thematic Mapper (TM) and Enhanced TM Plus (ETM+) images for total of 38,664 sample units pre-determined with an equal-area stratified sampling scheme. This was supplemented by MODIS enhanced vegetation index (EVI) time series data other high-resolution imagery Google Earth. Initially designed validating 30 m-resolution in Finer Resolution Observation...
Abstract Background Post‐ischemic angiogenesis is critical for blood flow recovery and ischemic tissue repair. N6‐methyladenosine (m6A) plays essential roles in numerous biological processes. However, the impact connected mechanism of m6A on post‐ischemic are not fully understood. Methods AlkB homolog 5 (ALKBH5) was screened out among several methyltransferases demethylases involved dynamic regulation. Cardiac microvascular endothelial cells (CMECs) WNT family member 5A (WNT5A) stability...
Abstract NEDD8 (Neural precursor cell expressed developmentally downregulated protein 8) is an ubiquitin-like that covalently attached to a lysine residue of substrate through process known as neddylation, catalyzed by the enzyme cascade, namely activating (E1), conjugating (E2), and ligase (E3). The substrates neddylation are categorized into cullins non-cullin proteins. Neddylation activates CRLs (cullin RING ligases), largest family E3 ligases, whereas alters their stability activity,...
In this paper, a subtle relationship is found between the volume of subsimplex and gradient simplex with respect to hyperspectral images. By using relationship, we propose an efficient band selection method, namely, volume-gradient-based (VGBS) method. The VGBS method unsupervised which tries remove most redundant successively. Interestingly, can find based only on instead calculating volumes all subsimplexes. Experiments simulated real data verify efficiency proposed
MLN4924, a newly discovered small molecule inhibitor of NEDD8-activating enzyme (NAE), inactivates Cullin-RING E3 ubiquitin Ligases (CRLs) by blocking cullin neddylation. As result, MLN4924 causes accumulation several key substrates CRLs and effectively suppresses tumor cell growth inducing apoptosis senescence. However, the role in induction autophagy its biological significance are totally unknown. Here we showed that induces both time- dose-dependent manners multiple human cancer lines,...
Extracting surface water distribution with satellite imagery has been an important subject in remote sensing. Spectral indices of only use information from a limited number bands, thus they may have poor performance pixels contaminated by ice/snow, clouds, etc. The detection algorithms using all spectral such as constrained energy minimization (CEM), could avoid this problem to some extent. However, these are mostly designed for hyperspectral imagery, and fail when applied multispectral...
Post-transcriptional modifications play pivotal roles in various pathological processes and ischemic disorders. However, the role of N7-methylguanosine (m7G), particularly m7G mRNA, on post-ischemic angiogenesis remains largely unknown. Here, we identified that methyltransferase like 1 (METTL1) was a critical candidate responsible for global decrease within mRNA from tissues. The vivo gene transfer METTL1 improved blood flow recovery increased with enhanced upon injury. Increased expression...
Abstract Mesenchymal stem cell‐derived extracellular vesicle (MSC‐EV) is shown to promote cardiac repair, however, it still falls short in initiating myocardia proliferation restart. In this regard, ROS‐induced DNA damage and responses are the culprit of cellcycle arrest. Here, work constructs a hybrid that composed MSC macrophage membranes encompasses MitoN, ROS scavenger, boost healing heart. The NAD(P)H mimic, could target mitochondrial eliminate resuming arrested cell cycle. (N@MEV)...
SIPRα on macrophages binds with CD47 to resist proengulfment signals, but how the downstream signal of controls tumor-infiltrating (TIMs) is still poorly clarified. Here, we report that CD47/signal regulatory protein α (SIRPα) axis requires deneddylation tyrosine phosphatase SHP2. Mechanistically, Src homology region 2–containing 2 (SHP2) was constitutively neddylated K358 and K364 sites; thus, its autoinhibited conformation maintained. In response CD47-liganded SIRPα, SHP2 deneddylated by...
Abstract Cardiac fibroblasts (CFs) are the primary cells tasked with depositing and remodeling collagen significantly associated heart failure (HF). TEAD1 has been shown to be essential for development homeostasis. However, fibroblast endogenous in cardiac remains incompletely understood. Transcriptomic analyses revealed consistently upregulated expression mice 4 weeks after transverse aortic constriction (TAC) Ang-II infusion. Further investigation that CFs were cell type expressing...
Abstract 3D‐printed cell‐laden hydrogels as tissue constructs show great promise in generating living tissues for medicine. Currently, the maturation of into remains challenge, since commonly used struggle to provide an ideal microenvironment seeded cells. In this study, a cell‐adaptable nanocolloidal hydrogel is created 3D printing maturable constructs. The composed interconnected nanoparticles, which prepared by self‐assembly and subsequent photocrosslinking gelatin methacryloyl solutions....
Cullin-RING ligases (CRLs) are a family of E3 ubiquitin ligase complexes that rely on either RING-box 1 (RBX1) or sensitive to apoptosis gene (SAG), also known as RBX2, for activity. RBX1 and SAG both overexpressed in human lung cancer; however, their contribution patient survival tumorigenesis is unknown. Here, we report overexpression SAG, but not RBX1, correlates with poor prognosis more advanced disease. We found murine KrasG12D-driven tumors Sag deletion suppressed extended life span....
The Moderate Resolution Imaging Spectroradiometer (MODIS)-Terra surface reflectance product (MOD09A1), with bands 1 to 7, is a gridded, eight-day composite derived from the MODIS-Terra top of atmosphere swaths. It performs cloud detection and corrects for effects atmospheric gases aerosols. mask (CM) algorithms MODIS are based on empirical thresholds spectral brightness temperature. Since spatial resolution thermal band 1000 m, while that MOD09A1 500 many undetected false clouds observed in...
Analysis of codon usage bias is an extremely versatile method using in furthering understanding the genetic and evolutionary paths species. Codon envelope glycoprotein genes nuclear polyhedrosis virus (NPV) has remained largely unexplored at present. Hence, NPV was analyzed here to reveal relationships between different viral species baculovirus genus. A total 9236 codons from 18 genera were used perform this analysis. Glycoprotein exhibits weaker bias. Neutrality plot analysis correlation...