A5006469973- Chromatin Remodeling and Cancer
- Signaling Pathways in Disease
- RNA modifications and cancer
- Mechanisms of cancer metastasis
- Liver physiology and pathology
- interferon and immune responses
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related gene regulation
- RNA regulation and disease
- Immune cells in cancer
- Nuclear Receptors and Signaling
- Epigenetics and DNA Methylation
- Histone Deacetylase Inhibitors Research
- Cholesterol and Lipid Metabolism
- Liver Disease Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Cancer-related molecular mechanisms research
- Immune Response and Inflammation
- RNA Research and Splicing
- Fiber-reinforced polymer composites
- Cancer Mechanisms and Therapy
- Medicinal Plant Pharmacodynamics Research
- Liver Disease and Transplantation
- Cardiac Fibrosis and Remodeling
- Galectins and Cancer Biology
The University of Texas Southwestern Medical Center
2021-2023
Guangdong Medical College
2023
Southwestern Medical Center
2022
Nanjing Medical University
2013-2021
Shanghai Stomatological Hospital
2021
Fudan University
2021
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
2021
General Hospital of Shenyang Military Region
2018-2020
First Affiliated Hospital of Xi'an Jiaotong University
2020
Kunming University of Science and Technology
2018
Background: Excessive accumulation of reactive oxygen species (ROS), catalyzed by the NADPH oxidases (NOX), is involved in pathogenesis ischemia-reperfusion (IR) injury. The underlying epigenetic mechanism remains elusive. Methods: We evaluated potential role megakaryocytic leukemia 1 (MKL1), as a bridge linking activation NOX to ROS production and cardiac Results: Following IR injury, MKL1-deficient (knockout) mice exhibited smaller myocardial infarction along with improved heart function...
Rationale: Endothelial dysfunction inflicted by inflammation is found in a host of cardiovascular pathologies. One hallmark event this process the aggregation and adhesion leukocyte to vessel wall mediated upregulation molecules (CAM) endothelial cells at transcriptional level. The epigenetic modulator(s) CAM transactivation its underlying pathophysiological relevance remain poorly defined. Objective: Our goal was determine involvement Brahma related gene 1 (Brg1) (Brm) pathogenesis...
This paper presents the use of electrodeformation as a method for single cell mechanical characterization in which properties SiHa and ME180 cells (two cervical cancer lines) were quantified. Cells directly placed between two microelectrodes with rectangular ac electric field applied, deformation was recorded under certain experimental conditions. Numerical simulations performed to model based on Maxwell stress tensor formulation. In these simulations, effects electrical property variations...
Icariin, a major active ingredient in traditional Chinese medicines, is attracting increasing attention because of its unique pharmacological effects against ischaemic heart disease. The histone deacetylase, sirtuin-1, plays protective role ischaemia/reperfusion (I/R) injury, and this study was designed to investigate the icariin models cardiac I/R injury elucidate potential involvement sirtuin-1.
Chronic inflammation underscores the pathogenesis of a range human diseases. Lipopolysaccharide (LPS) elicits strong pro-inflammatory response in macrophages via transcription factor NF-κB. The epigenetic mechanism underlying LPS-induced is not completely appreciated. Herein we describe role for myocardin related A, or MRTF-A, this process. MRTF-A over-expression potentiated while silencing dampened NF-κB dependent transcription. deficiency also alleviated synthesis mediators mouse model...
Abstract Excessive fibrogenic response in the liver disrupts normal hepatic anatomy and function heralding such end-stage diseases as hepatocellular carcinoma cirrhosis. Sinusoidal endothelial cells contribute to myofibroblast activation fibrosis by undergoing endothelial-mesenchymal transition (EndMT). The underlying mechanism remains poorly defined. Here we report that inhibition or endothelial-specific deletion of MKL1, a transcriptional modulator, attenuated mice. MKL1 suppressed EndMT...
Activation of hepatic stellate cells (HSC) is a hallmark event in liver fibrosis. Accumulation reactive oxygen species (ROS) serves as driving force for HSC activation. The regulatory subunits the NOX complex, NCF1 (p47phox) and NCF2 (p67phox), are up-regulated during activation contributing to ROS production transcriptional mechanism underlying NCF1/2 up-regulation not clear. In present study we investigated role serum response factor (SRF) focusing on regulation NCF1/2. We report that...
Periodontitis is initiated by serious and sustained bacterial infection ultimately results in chronic immune-mediated inflammation, tissue destruction, bone loss. The pathogenesis of periodontitis remains unclear. Host immunological responses to periodontal bacteria determine the severity mechanisms governing progression. This study aimed clarify effect hypoxia-inducible factor-1α (HIF-1α) activator dimethyloxalylglycine (DMOG) on a mouse model its underlying role macrophage polarization....
Abstract Hypercholesterolemia and vascular inflammation are key interconnected contributors to the pathogenesis of atherosclerosis. How hypercholesterolemia initiates is poorly understood. Here we show in male mice that hypercholesterolemia-driven endothelial activation, monocyte recruitment atherosclerotic lesion formation promoted by a crosstalk between macrophages cells mediated cholesterol metabolite 27-hydroxycholesterol (27HC). The pro-atherogenic actions macrophage-derived 27HC...
ObjectivesNo extensive investigation has been performed and thus no representative data are available regarding acute liver failure (ALF) in China. This study aims to investigate the causes outcomes of ALF China establish a prognostic model. MethodsPatients diagnosed as seven hospitals different areas from January 2007 December 2012 were retrospectively selected. ResultsOf 177 patients included this study, 112 (63.28%) eventually died. The common drug toxicity (43.50%), indeterminate...
Macrophage-dependent inflammatory response is considered a pivotal biological process that contributes to host of diseases when aberrantly activated. The underlying epigenetic mechanism not completely understood. We report here MKL1 was both sufficient and necessary for p65-dependent pro-inflammatory transcriptional program in immortalized macrophages, primary human mouse an animal model systemic inflammation (endotoxic shock). Extensive chromatin immunoprecipitation (ChIP) profiling...
Uncontrolled inflammatory response highlights the central theme of nonalcoholic steatohepatitis (NASH), a growing global pandemic. Hepatocytes and macrophages represent two major sources hepatic inflammation during NASH pathogenesis, contributing to excessive synthesis proinflammatory mediators. The epigenetic mechanism that accounts for activation hepatocytes in this process remains obscure. Here, we report compared wild‐type littermates, mice with deficiency histone H3K9 methyltransferase...
Trans-differentiation of endothelial cells to myofibroblast contributes liver fibrosis. Reactive oxygen species (ROS) plays a key role in endothelial-mesenchymal transition (EndMT) although the underlying epigenetic mechanism is unclear. Here we report that conditional knockout Brg1, chromatin remodeling protein, attenuated fibrosis mice. Brg1 deficiency was paralleled by decrease ROS production and blockade EndMT both vivo vitro. The ability BRG1 regulate abolished NOX4 depletion or...