A5040829339- Mesenchymal stem cell research
- Analytical Chemistry and Chromatography
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Periodontal Regeneration and Treatments
- Tissue Engineering and Regenerative Medicine
- Neuroscience of respiration and sleep
- Plant biochemistry and biosynthesis
- Protein Interaction Studies and Fluorescence Analysis
- Enzyme Structure and Function
- Microfluidic and Capillary Electrophoresis Applications
- Chemical Synthesis and Analysis
- Innovative Energy Harvesting Technologies
- Ionic liquids properties and applications
- Neurogenesis and neuroplasticity mechanisms
- Obstructive Sleep Apnea Research
- Energy Harvesting in Wireless Networks
- Extracellular vesicles in disease
- Asymmetric Synthesis and Catalysis
- Pluripotent Stem Cells Research
- RNA modifications and cancer
- Inorganic Fluorides and Related Compounds
- Supramolecular Chemistry and Complexes
- Fluorine in Organic Chemistry
- Crystallography and molecular interactions
Xi'an Jiaotong University
2021-2025
Henan University
2024-2025
Shihezi University
2024-2025
Qingdao University of Science and Technology
2025
Tianjin First Center Hospital
2015-2024
Tianjin Medical University
2015-2024
Shanghai Stomatological Hospital
2017-2024
Fudan University
2017-2024
Chimie ParisTech
2024
Université Paris Sciences et Lettres
2024
The plant hormone auxin is perceived by the nuclear F-box protein TIR1 receptor family and regulates gene expression through degradation of Aux/IAA transcriptional repressors. Several studies have revealed importance proteasome in signalling, but details on how proteolytic machinery regulated this relates to proteins remains unclear. Here we show that an Arabidopsis homologue inhibitor PI31, which name PROTEASOME REGULATOR1 (PTRE1), a positive regulator 26S proteasome. Loss-of-function ptre1...
Several organic reactions conducted at high temperatures, including the isomerization reaction, Claisen rearrangement, and Diels−Alder were investigated in three geminal dicationic ionic liquids with thermal stability. High to moderate yields of products for most entries obtained. Advantages these approaches are discussed. These shown be recyclable. The utility liquid solvents high-temperature was demonstrated.
Tissue hypoxia caused by upper airway collapse is a main cause of excessive oxidative stress and systemic inflammation in obstructive sleep apnea (OSA) patients. Increased reactive oxygen species (ROS) inflammatory responses affect cell survival ultimately contribute to tissue injury. In the present study, we proposed that induction ROS hypoxia, as an intrinsic stress, activates myoblast pyroptosis OSA. We found increased death abnormal expression markers skeletal muscle OSA mice. vitro...
Abstract Extracellular vesicles (EVs) derived from mesenchymal stem cells (MSCs) have emerged as an appealing alternative to cell therapy in regenerative medicine. Unlike bone marrow MSCs (BMSCs) cultured vitro with normoxia, vivo is exposed a hypoxic environment. To date, it remains unclear whether hypoxia preconditioning can improve the function of BMSC‐derived EVs and be more conducive repair. Herein, found that preconditioned BMSCs secrete biglycan (Bgn)‐rich via proteomics analysis,...
Six chiral ionic liquids were prepared and evaluated as "chiral induction solvents" in which two different dibenzobicyclo[2.2.2]octatrienes photoisomerized to products. Enantiomeric excesses from 3 12% obtained the photochemical di-π-methane rearrangement. Results indicate that derives an ion pairing interaction of deprotonated diacids with liquid cation. This is first report on via a IL for irreversible, unimolecular isomerization.
Periodontitis is initiated by serious and sustained bacterial infection ultimately results in chronic immune-mediated inflammation, tissue destruction, bone loss. The pathogenesis of periodontitis remains unclear. Host immunological responses to periodontal bacteria determine the severity mechanisms governing progression. This study aimed clarify effect hypoxia-inducible factor-1α (HIF-1α) activator dimethyloxalylglycine (DMOG) on a mouse model its underlying role macrophage polarization....
Ovarian cancer is high recurrence and mortality malignant tumor. The most common ovarian was High-Grade Serous Cancer. However, Cancer organoid rare, which with patient immune microenvironment blood vessels even absence. Here, we report a novel system derived from samples. These organoids recapitulate organoids' histological molecular heterogeneity while preserving the critical vessels, as evidenced by presence of
Alveolar bone defects can arise as a consequence of trauma, infection, periodontal disease, or congenital alveolar fenestration. Many approaches have been employed in an effort to treat overcome such defects, but the ability effectively achieve regeneration remains elusive. Platelet-derived growth factor-BB (PDGF-BB) has shown serve key factor capable orchestrating cell proliferation, angiogenesis, and chemoattraction context osteogenic processes. Exactly how PDGF-BB affects human ligament...
Small extracellular vesicles (sEVs) are natural biocarriers for biomolecule transfer between cells and promising therapeutic strategies bone defect repair. In this study, human periodontal ligament stem cell (PDLSC)-derived sEVs (P-EVs) were immobilized in Matrigel to establish a topical cell-free transplantation strategy repair.PDLSCs cultured P-EVs isolated from the culture supernatant. rat bilateral calvarial model, P-EV/Matrigel was plugged into one PBS/Matrigel applied other. Bone...
Abstract The recent detection of potent carcinogenic nitrosamine impurities in several human medicines has triggered product recalls and interrupted the supply critical medications for hundreds millions patients, illuminating need increased testing nitrosamines pharmaceutical products. However, development analytical methods is challenging due to high sensitivity requirements, complex matrices, large number variety samples requiring testing. Herein, we report an method analysis a common...
Abstract The alkaloids containing a carbazole nucleus are an established class of natural products with wide range biological activities. A combination thermodynamic and enzymatic activity studies provides insight into the recognition Clausine E by fat mass obesity‐associated protein (FTO). binding to FTO was driven positive entropy negative enthalpy changes. Results also indicated that hydroxyl group crucial for small molecules FTO. structural information basis design more effective...
Neural stem cells (NSCs) can generate new neurons to repair brain injury and central nervous system disease by promoting neural regeneration. MicroRNAs (miRNAs) involve in development, damage, neurological diseases repair. Recent reports show that several miRNAs express NSCs are important neurogenesis. Neurites play a key role NSC-related However, the mechanism of NSC neurite generation is rarely studied. We surprisingly noticed neurites increased after bone morphogenetic protein (BMP)...