A5006321396- Cancer Cells and Metastasis
- Helicobacter pylori-related gastroenterology studies
- 3D Printing in Biomedical Research
- Cancer, Hypoxia, and Metabolism
- Gut microbiota and health
- Mycobacterium research and diagnosis
- Metastasis and carcinoma case studies
- Single-cell and spatial transcriptomics
- Circular RNAs in diseases
- Gastric Cancer Management and Outcomes
- Cancer-related gene regulation
- Advanced MRI Techniques and Applications
- Cancer-related molecular mechanisms research
- Renal function and acid-base balance
- RNA modifications and cancer
- Immune cells in cancer
- Ovarian cancer diagnosis and treatment
- Cancer Genomics and Diagnostics
- Reproductive System and Pregnancy
- Diet and metabolism studies
- Chemokine receptors and signaling
- Intraperitoneal and Appendiceal Malignancies
- Reproductive Biology and Fertility
Sixth Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen University
2021-2024
Shanghai Xuhui Central Hospital
2024
Fudan University
2023-2024
The First Affiliated Hospital, Sun Yat-sen University
2021-2024
Viva Biotech (China)
2024
Zhongshan Hospital
2023-2024
Northwest University
2024
University of Washington
1989
Abstract Background Chemoresistance is a major cause of treatment failure in gastric cancer (GC). Heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) an N6‐methyladenosine (m 6 A)‐binding protein involved variety cancers. However, whether m A modification and hnRNPA2B1 play role GC chemoresistance largely unknown. In this study, we aimed to investigate the downstream mechanism chemoresistance. Methods The expression among public datasets were analyzed validated by quantitative PCR...
The escape of solutes from the blood during passage along capillaries in heart and skeletal muscle occurs via diffusion through clefts between endothelial cells and, for some solutes, adsorption to or transport across luminal plasmalemma cell. To quantitate rates permeation these two routes capillary wall, we have developed a linear model transendothelial illustrated its suitability design analysis multiple simultaneous indicator dilution curves an organ. Data should be obtained at least...
Ovarian cancer is high recurrence and mortality malignant tumor. The most common ovarian was High-Grade Serous Cancer. However, Cancer organoid rare, which with patient immune microenvironment blood vessels even absence. Here, we report a novel system derived from samples. These organoids recapitulate organoids' histological molecular heterogeneity while preserving the critical vessels, as evidenced by presence of
Uncertainty exists regarding the mechanisms by which hypoxia-inducible factors (HIFs) control CD8
While tumor organoids have revolutionized cancer research by recapitulating the cellular architecture and behaviors of real tumors in vitro, their lack functional vasculature hinders attainment full physiological capabilities. Current efforts to vascularize are struggling achieve well-defined vascular networks, mimicking intricate hierarchy observed vivo, which restricts relevance particularly for studying progression response therapies targeting vasculature. An innovative vascularized...
Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory disorder of the gastrointestinal tract for which treatment options remain limited. In this study, we used dual-luciferase-based screening an FDA-approved drug library, identifying Bazedoxifene (BZA) as inhibitor NF-κB pathway. We further investigated its therapeutic effects in dextran sodium sulfate (DSS)-induced colitis model explored impact on gut microbiota regulation underlying molecular mechanisms. Our results...