A5100353632- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Single-cell and spatial transcriptomics
- Chromatin Remodeling and Cancer
- Hepatocellular Carcinoma Treatment and Prognosis
- Macrophage Migration Inhibitory Factor
- Neuropeptides and Animal Physiology
- Treatment of Major Depression
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Wnt/β-catenin signaling in development and cancer
- Mechanisms of cancer metastasis
- AI in cancer detection
- Cytokine Signaling Pathways and Interactions
- Family Support in Illness
- Child and Adolescent Psychosocial and Emotional Development
- Medical Imaging Techniques and Applications
- Genomics and Chromatin Dynamics
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- HER2/EGFR in Cancer Research
- Cancer Cells and Metastasis
- Galectins and Cancer Biology
- Glioma Diagnosis and Treatment
- Pharmacological Receptor Mechanisms and Effects
- Cancer Genomics and Diagnostics
Hangzhou Women’s Hospital
2024
Fudan University
2015-2023
Sun Yat-sen University
2015-2023
Zhongshan Hospital
2015-2023
The First Affiliated Hospital, Sun Yat-sen University
2015-2023
National Institute of Measurement and Testing Technology
2023
Jiangsu Cancer Hospital
2022
Southern Medical University
2018
Nanfang Hospital
2018
Xuzhou Medical College
2017
We aimed to evaluate whether radiomic feature-based fluorine 18 ( F) fluorodeoxyglucose (FDG) positron emission tomography (PET) imaging signatures allow prediction of gastric cancer (GC) survival and chemotherapy benefits.Methods: A total 214 GC patients (training (n = 132) or validation 82) cohort) were subjected feature extraction (80 features).Radiomic features in the training cohort a LASSO cox analysis predict disease-free (DFS) overall (OS) validated cohort.A radiomics nomogram with...
Brg1/SMARCA4 serves as the ATPase and helicase catalytic subunit for multi-component SWI/SNF chromatin remodeling complex, which plays a pivotal role in governing structure gene transcription. However, upstream signaling pathways regulating Brg1 protein stability its physiological contribution to carcinogenesis remain largely elusive. Here we report that is bona fide ubiquitin substrate of SCFFBW7. We reveal CK1δ phosphorylates at Ser31/Ser35 residues facilitate binding FBW7, leading...
The prognosis of gastric cancer (GC) remains poor due to local invasion and distal metastasis. GC-related molecular mechanisms underlying metastasis are not well understood. In this study, we investigated the functional role ANO1 in GC progression. We found that is overexpressed tissues correlated with tumor-node-metastasis stage. Knockdown significantly inhibited cell migration vitro, loss resulted inhibition tumor vivo. Mechanistically, SP1 increased transcription, recruited MLL1 promoter...
Pulmonary nodules (PNs) shown as persistent or growing ground-glass opacities (GGOs) are usually lung adenocarcinomas their preinvasive lesions. Tumor mutation burden (TMB) and somatic mutations important determinants for the choice of strategy in patients with cancer during therapy. A total 93 post-operative 108 malignant PNs were enrolled analysis (75 cases training cohort 33 validation cohort). Radiomics features extracted from preoperative non-contrast computed tomography (CT) images...
Abstract Gastric cancer ranks fourth for mortality globally among various malignant tumours, and invasion metastasis are the major reason leading to its poor prognosis. Recently, accumulating studies revealed role of reticulon proteins in cell growth transmigration. However, expression biological function human gastric remain largely unclear. Herein, we explored potential 2 (RTN2) progression cancer. Tissue microarray was used determine levels RTN2 267 patients by immunohistochemistry. lines...
The reasons for hospice underuse in China need exploration from the perspective of patients with cancer and their families. Furthermore, existing literature about decision-making among Chinese families is limited. This study aimed to investigate awareness care patients, preference healthcare at end-of-life stage care, predictors preference.
Abstract Breast cancer is a common malignant tumor of women. Ki67 an important biomarker cell proliferation. With the quantitative analysis, it indicator malignancy for breast diagnosis. However, difficult to accurately and quantitatively evaluate count positive nucleus during diagnosis process pathologists, time-consuming labor-intensive. In this work, we employed analysis method in based on deep learning approach. For cancer, according guideline, first identified region pathological image,...
Panic attacks are common among patients who have undergone heart transplantation, but there no clinical guidelines for the treatment of panic in this group patients. This report describes a 22-year-old woman experienced 10 years after transplant surgery. The started she discovered that average post-transplantation survival is years. Treated with citalopram mg/d, her symptoms improved significantly 2 weeks and had completely resolved 8 weeks. A positive physician-patient relationship doctors...
Objective To explore the diagnostic value of CT quantitative detection in chronic obstructive pulmonary disease (COPD). Methods A total 113 patients with suspected COPD who were hospitalized an outpatient department a hospital from January 2018 to December 2020 selected as subjects study. All underwent examination, lung function and other related examinations. The results examination used gold standard detect COPD, application diagnosis was analyzed. Results Among 157 C0PD, 112 (71.34%) 20...
e15529 Background: Receptor of activated C kinase 1 (RACK1) is regarded as a scaffolding protein in multiple intracellular signal transduction pathways. Our previous works had demonstrated that RACK1 might involve progression gastric cancer, and could be criterion to predict the good prognosis for patients after surgical resection. The aim this study explore regulatory role matrix metalloproteinase 10 (MMP10) autocrine, which may involved invasion cancer. Methods: knockdown cell lines were...
Background: Ras-GTPase-activating protein SH3 domain-binding 1 (G3BP1) was reported to be overexpressed and associated with poor survival in tumors. However, the precise function underlying mechanism of G3BP1 gastric cancer remains obscure.Methods: The biological effects on apoptosis chemoresistance were evaluated both vitro vivo using flow cytometry, colony formation, xenografts. interaction between YWHAZ assessed by immunoprecipitation immunofluorescence. expression examined...