A5100632776- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- Helicobacter pylori-related gastroenterology studies
- Immune cells in cancer
- Colorectal Cancer Surgical Treatments
- Cancer Immunotherapy and Biomarkers
- Galectins and Cancer Biology
- Glycosylation and Glycoproteins Research
- Cancer Research and Treatments
- Cytokine Signaling Pathways and Interactions
- Cancer Mechanisms and Therapy
- Cancer-related molecular mechanisms research
- Wnt/β-catenin signaling in development and cancer
- Peptidase Inhibition and Analysis
- Biliary and Gastrointestinal Fistulas
- Gallbladder and Bile Duct Disorders
- Radiomics and Machine Learning in Medical Imaging
- Minimally Invasive Surgical Techniques
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
Fudan University Shanghai Cancer Center
2024-2025
Shanghai Medical College of Fudan University
2012-2025
The First Affiliated Hospital, Sun Yat-sen University
2013-2023
Sun Yat-sen University
2013-2023
Zhongshan Hospital
2014-2023
Fudan University
2014-2023
Longyan University
2018
Southern Medical University
2016
Nanfang Hospital
2016
Fujian Medical University
2016
The safety and efficacy of radical laparoscopic distal gastrectomy (LG) with D2 lymphadenectomy for the treatment advanced gastric cancer (AGC) remain controversial. We conducted a randomized controlled trial to compare conventional open lymph node dissections AGC.Between September 2012 December 2014, 1,056 patients clinical stage T2-4aN0-3M0 were eligible inclusion. They randomly assigned either LG group (n = 528) or (OG) 528). Fifteen experienced surgeons from 14 institutions in China...
<h3>Importance</h3> Laparoscopic distal gastrectomy is accepted as a more effective approach to conventional open for early-stage gastric cancer. However, efficacy locally advanced cancer remains uncertain. <h3>Objective</h3> To compare 3-year disease-free survival patients with after laparoscopic or gastrectomy. <h3>Design, Setting, and Patients</h3> The study was noninferiority, open-label, randomized clinical trial at 14 centers in China. A total of 1056 eligible stage T2, T3, T4a without...
The safety of laparoscopic total gastrectomy (LTG) for the treatment gastric cancer remains uncertain given lack high-level clinical evidence.To compare LTG stage I with that conventional open (OTG).The Chinese Laparoscopic Gastrointestinal Surgery Study (CLASS) Group CLASS02 study was a prospective, multicenter, open-label, noninferiority, randomized trial compared vs OTG lymphadenectomy patients cancer. From January 2017 to September 2018, 227 were enrolled. Final follow-up in October...
<h3>Importance</h3> It is not clear whether laparoscopic and open distal gastrectomy produce similar outcomes among patients with locally advanced gastric cancer. Data from a multicenter, randomized clinical trial (Chinese Laparoscopic Gastrointestinal Surgical Study [CLASS]–01) showed that did result in inferior disease-free survival at 3 years compared gastrectomy. <h3>Objective</h3> To report 5-year overall data the CLASS-01 of vs <h3>Design, Setting, Patients</h3> This was...
Cancer-associated fibroblasts (CAF) play a crucial role in tumor progression and immune regulation. However, the functional heterogeneity of CAFs remains unclear. Here, we identify antigen-presenting (apCAF), characterized by high MHC II expression, gastric cancer (GC) tumors find that apCAFs are preferentially located near tertiary lymphoid structures. Both vivo vitro experiments demonstrate promote T cell activation enhances its cytotoxic proliferative capacities, thereby strengthening...
The aim of this study was to identify and evaluate microRNAs (miRNAs) in gastric cancer lymph node metastasis. A miRNA array used compare the expression miRNAs primary paired metastases. found be differentially expressed were validated a cohort tissues, relationship between clinicopathological characteristics specimens analyzed. level miR-10a mucosal cell line three lines also detected using qPCR. Moreover, target genes for predicted bioinformatic methods. Based on results, four by array....
The immune microenvironment plays a critical role in tumor biology. molecular profiles of components and related genes are tremendous value for the study primary resistance to checkpoint blockers (ICBs) gastric cancer (GC) serve as prognostic biomarkers predict GC survival. Recent studies have revealed that cell infiltration (ICI) is an indicator survival responsiveness chemotherapy patients. Here, we describe landscape based on ESTIMATE CIBERSORT algorithms help separate into 3 ICI clusters...
The present study investigated the clinical significance of Snail, a zinc-finger transcription factor, in development and progression gastric cancer. To elucidate relationship between Snail expression dedifferentiation status with cancer stem cell phenotype cells, we used western blot analysis, RT-PCR, quantitative real-time PCR flow cytometry. Immunohistochemistry staining evaluation 10 human normal samples versus 103 clinicopathologically characterized tissues followed by statistical...
Aberrant chemokine (C-X-C motif) receptor CXCR4 expressions in malignant tissues have been reported, but its role gastric cancer prognosis remains unknown. Our studies were designed to investigate the expression and prognostic significance of patients with cancer. was retrospectively analyzed by immunohistochemistry 97 adenocarcinoma from China. Results assessed for association clinical features overall survival using Kaplan-Meier analysis. Prognostic values outcomes evaluated Cox regression...
Abstract Background The Neo-REGATTA study evaluated the effectiveness and safety of Docetaxel, oxaliplatin, S-1 (DOS regimen) followed by radical resection vs. chemotherapy in advanced gastric adenocarcinoma patients with single non-curable factor. Methods This cohort prospectively enrolled factor between November 2017 June 2021. Patients without progression after four cycles DOS were divided into group group. outcomes included overall survival (OS), progression-free (PFS) safety....
472 Background: Despite significant advancements in immunotherapy, the identification of effective predictive biomarkers for treatment response gastric adenocarcinoma (GAC) remains a critical challenge. Discovering such could enhance patient stratification and improve therapeutic outcomes. Methods: We conducted comprehensive analysis 18 specimens obtained from 10 GAC patients, both prior to following immunotherapy. Utilizing single-cell RNA sequencing, we compared cellular composition...
Neoadjuvant therapy (NAT) is a cornerstone in the treatment of locally advanced gastric cancer, improving surgical outcomes and survival. However, optimal timing for surgery following NAT remains controversial. This study evaluates impact interval between on overall survival (OS) explores associated clinicopathological factors. A retrospective analysis 893 patients undergoing curative adenocarcinoma across three centers China was conducted. Surgical intervals were categorized (∼28 days,...
Abstract Gastric cancer remains the third leading cause of cancer-related death, and tumor metastasis is main risk factor for poor prognosis patients with gastric cancer. Transcription EB (TFEB) a MiT family member has been found to drive tumorigenesis in number tissues, whereas few studies were focused on investigating its prometastasis role mechanism Here, we TFEB was upregulated tissues compared adjacent normal epithelial tissues. IHC analysis from tissue microarray revealed that...
The NEO-CLASSIC study provided valuable insight for the clinical efficacy and tolerability profiles of perioperative chemotherapy with oxaliplatin capecitabine, plus gastrectomy, in patients localized resectable gastric cancer.The was designed to explore potential survival benefits an eight-cycle, capecitabine (XELOX) schedule above-mentioned setting feasibility prolonging cycles preoperative chemotherapy. projected endpoint not met.This multicenter, open-label (NEO-CLASSIC) evaluated safety...
The aim of this study was to compare the efficacies XELOX and DOS regimens as preoperative chemotherapy in patients with locally advanced gastric cancer. All cases cancer treated or regimen were reviewed retrospectively. Propensity score matching (PSM) carried out reduce selection bias based on age, gender, location, Lauren type, carcinoembryonic antigen level, clinical tumor stage, node stage. From January 2010 December 2016, 248 matched; 159 them received 89 regimen. response rates groups...
A new staging system recently proposed by the IGCA has demonstrated a better capacity of stratifying different prognoses for gastric cancer than 7th edition AJCC (AJCC7). The aim this study was to evaluate efficacy in Chinese patients. Medical records patients with who received curative surgery our center from January 2003 December 2011 were reviewed retrospectively. All lesions staged according both AJCC7 and systems. Overall survival (OS) used as observation endpoint. One thousand five...
The safety of laparoscopic total gastrectomy (LTG) for the treatment gastric cancer remains lack clinical evidence. Chinese Laparoscopic Gastrointestinal Surgery Study (CLASS) Group recently launched a multicenter randomized trial (CLASS02–01) to compare LTG stage I with conventional open (OTG). This CLASS02–01 is prospective, multicenter, randomized, controlled, open, and non-inferiority trial. Two hundred patients who met inclusion criteria did not accord exclusion will be randomly divided...
Different subtypes of gastric cancer differentially respond to immune checkpoint inhibitors (ICI). This study aimed investigate whether the Estimation STromal and Immune cells in Malignant Tumor tissues using Expression data (ESTIMATE) algorithm is related classification prognosis establish an ESTIMATE-based gene signature predict for patients. The immune/stromal scores 388 patients from TCGA were used this analysis. upregulated expressed genes (DEGs) with high stromal/immune identified....