A5002196001- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Helicobacter pylori-related gastroenterology studies
- Ferroptosis and cancer prognosis
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Inflammatory Biomarkers in Disease Prognosis
- Neuroendocrine Tumor Research Advances
- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Research Studies
- Inflammatory mediators and NSAID effects
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Cancer Immunotherapy and Biomarkers
- Cancer-related gene regulation
- Colorectal Cancer Treatments and Studies
- Nutrition and Health in Aging
Union Hospital
2016-2025
Fujian Medical University
2016-2025
First Hospital of Jilin University
2025
Jilin University
2025
Second Affiliated Hospital of Fujian Medical University
2023-2024
Beijing University of Posts and Telecommunications
2024
Fujian Provincial Hospital
2024
Shenzhen Children's Hospital
2024
Shantou University
2024
Shantou University Medical College
2024
The safety and efficacy of radical laparoscopic distal gastrectomy (LG) with D2 lymphadenectomy for the treatment advanced gastric cancer (AGC) remain controversial. We conducted a randomized controlled trial to compare conventional open lymph node dissections AGC.Between September 2012 December 2014, 1,056 patients clinical stage T2-4aN0-3M0 were eligible inclusion. They randomly assigned either LG group (n = 528) or (OG) 528). Fifteen experienced surgeons from 14 institutions in China...
<h3>Importance</h3> Laparoscopic distal gastrectomy is accepted as a more effective approach to conventional open for early-stage gastric cancer. However, efficacy locally advanced cancer remains uncertain. <h3>Objective</h3> To compare 3-year disease-free survival patients with after laparoscopic or gastrectomy. <h3>Design, Setting, and Patients</h3> The study was noninferiority, open-label, randomized clinical trial at 14 centers in China. A total of 1056 eligible stage T2, T3, T4a without...
The application of indocyanine green (ICG) imaging in laparoscopic radical gastrectomy is the preliminary stages clinical practice, and its safety efficacy remain controversial.To investigate ICG near-infrared tracer-guided during D2 lymphadenectomy patients with gastric cancer.Patients potentially resectable adenocarcinoma (clinical tumor stage cT1-cT4a, N0/+, M0) were enrolled a prospective randomized trial at tertiary referral teaching hospital between November 2018 July 2019. Patients...
<h3>Importance</h3> It is not clear whether laparoscopic and open distal gastrectomy produce similar outcomes among patients with locally advanced gastric cancer. Data from a multicenter, randomized clinical trial (Chinese Laparoscopic Gastrointestinal Surgical Study [CLASS]–01) showed that did result in inferior disease-free survival at 3 years compared gastrectomy. <h3>Objective</h3> To report 5-year overall data the CLASS-01 of vs <h3>Design, Setting, Patients</h3> This was...
Abstract Prospective evidence regarding the combination of programmed cell death (PD)−1 and angiogenesis inhibitors in treating locally advanced gastric cancer (LAGC) is limited. In this multicenter, randomized, phase 2 trial (NCT04195828), patients with adenocarcinoma (clinical T2-4N + M0) were randomly assigned (1:1) to receive neoadjuvant camrelizumab apatinib combined nab-paclitaxel plus S-1 (CA-SAP) or chemotherapy SAP alone (SAP) for 3 cycles. The primary endpoint was major...
To study the historical global incidence and mortality trends of gastric cancer predicted by 2035.
Abstract Immunosuppressive molecules are extremely valuable prognostic biomarkers across different cancer types. However, the diversity of immunosuppressive makes it very difficult to accurately predict clinical outcomes based only on a single molecule. Here, we establish comprehensive immune scoring system (ISS GC ) 6 ligands (NECTIN2, CEACAM1, HMGB1, SIGLEC6, CD44, and CD155) using LASSO method improve accuracy provide an additional selection strategy for adjuvant chemotherapy gastric...
Abstract Background BATF2, also known as SARI, has been implicated in tumor progression. However, its role, underlying mechanisms, and prognostic significance human gastric cancer (GC) are elusive. Methods We obtained GC tissues corresponding normal from 8 patients identified BATF2 a downregulated gene via RNA-seq. qRT-PCR western blotting were applied to examine levels tissues. The value of was elucidated using tissue microarray IHC analyses two independent cohorts. functional roles...
Indocyanine green (ICG) fluorescence imaging-guided lymphadenectomy has been demonstrated to be effective in increasing the number of lymph nodes (LNs) retrieved laparoscopic gastrectomy for gastric cancer (GC). Previously, we reported primary outcomes and short-term secondary a phase 3, open-label, randomized clinical trial (NCT03050879) investigating use ICG image-guided patients with potentially resectable GC. Patients were randomly (1:1 ratio) assigned either or non-ICG group. The...
Abstract Robotic surgery may be an alternative to laparoscopic for gastric cancer (GC). However, randomized controlled trials (RCTs) reporting the differences in survival between these two approaches are currently lacking. From September 2017 January 2020, 300 patients with cT1-4a and N0/+ were enrolled either robotic (RDG) or distal gastrectomy (LDG) group (NCT03313700). The primary endpoint was 3-year disease-free (DFS); secondary endpoints reported here overall (OS) recurrence patterns....
<h3>Importance</h3> Gastric neuroendocrine carcinoma and mixed adenoneuroendocrine are rare pathological types of gastric cancer, there is a lack multicenter studies comparing the prognosis recurrence patterns carcinoma, adenocarcinoma. <h3>Objective</h3> To compare differences in long-term survival among <h3>Design, Setting, Participants</h3> This cohort study included patients with resectable at 23 hospitals China from January 2006 to December 2016. In addition, adenocarcinoma were...
Neoadjuvant chemotherapy (NAC) is a standard treatment option for locally advanced gastric cancer (LAGC); however, the indications adjuvant (AC) in patients with LAGC who received NAC remain controversial.
Abstract LHPP, a histidine phosphatase, has been implicated in tumour progression. However, its role, underlying mechanisms, and prognostic significance human gastric cancer (GC) are elusive. Here, we obtained GC tissues corresponding normal from 48 patients identified LHPP as downregulated gene via RNA-seq. qRT-PCR western blotting were applied to examine levels tissues. The value of was elucidated using tissue microarray IHC analyses two independent cohorts. functional roles mechanistic...
Abstract Nerves can support tumor development by secreting neurotransmitters that promote cancer cell proliferation and invasion. 5-Hydroxytryptamine (5-HT) is a critical neurotransmitter in the gastrointestinal nervous system, 5-HT signaling has been shown to play role tumorigenesis. Here, we found expression of receptor HTR2B was significantly elevated human gastric adenocarcinoma tissues compared with nontumor tissues, high corresponded shorter patient survival. Both specific agonist...
The safety and efficacy of neoadjuvant immunochemotherapy (nICT) for locally advanced gastric cancer (LAGC) remain controversial.
Background: Pyroptosis plays a crucial role in immune responses.However, the effects of pyroptosis on tumor microenvironment remodeling and immunotherapy gastric cancer (GC) remain unclear.Patients Methods: Large-sample GEO data (GSE15459, GSE54129, GSE62254) were used to explore immunoregulatory roles pyroptosis.TCGA cohort was elucidate multiple molecular events associated with pyroptosis, risk score (PRS) constructed.The prognostic performance PRS validated using postoperative GC samples...
Background Emerging evidence indicates that dysregulation of circular RNAs (circRNAs) is implicated in the development malignancies. However, diagnostic value and functional role circRNAs gastric cancer (GC) remain largely elusive. Methods Quantitative reverse transcription‐polymerase chain reaction (qRT‐PCR) was performed to detect expression hsa_circ_0000467 tissues, cell lines, plasma. A receiver operating characteristic (ROC) curve constructed estimate hsa_circ_0000467. The association...