A5100303995- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal Cancer Research and Treatment
- Esophageal and GI Pathology
- Inflammatory Biomarkers in Disease Prognosis
- Colorectal Cancer Surgical Treatments
- Helicobacter pylori-related gastroenterology studies
- Neuroendocrine Tumor Research Advances
- Nutrition and Health in Aging
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Colorectal and Anal Carcinomas
- Corporate Finance and Governance
- Pancreatic and Hepatic Oncology Research
- Financial Markets and Investment Strategies
- Lung Cancer Research Studies
- Colorectal Cancer Screening and Detection
- Cancer-related gene regulation
- Inflammatory mediators and NSAID effects
- Cancer-related Molecular Pathways
- Enhanced Recovery After Surgery
- Coronary Interventions and Diagnostics
- Epigenetics and DNA Methylation
Fujian Medical University
2016-2025
Union Hospital
2016-2025
Peking University
2010-2025
Peking University Third Hospital
2010-2025
Sun Yat-sen University
2022-2024
Columbia University
2023-2024
Ministry of Education of the People's Republic of China
2011-2024
The University of Queensland
2014-2024
Chongqing University of Science and Technology
2024
Columbia University Irving Medical Center
2023
The application of indocyanine green (ICG) imaging in laparoscopic radical gastrectomy is the preliminary stages clinical practice, and its safety efficacy remain controversial.To investigate ICG near-infrared tracer-guided during D2 lymphadenectomy patients with gastric cancer.Patients potentially resectable adenocarcinoma (clinical tumor stage cT1-cT4a, N0/+, M0) were enrolled a prospective randomized trial at tertiary referral teaching hospital between November 2018 July 2019. Patients...
Objective: To evaluate the short-term outcomes of patients with GC who received RDG or LDG. Summary Background Data: Despite increasing use in GC, its safety and efficacy compared to those LDG have not been elucidated a randomized controlled trial. Methods: Three hundred cT1-4a N0/+ between September 2017 January 2020 were enrolled this trial at high-volume hospital China. The groups. Results: modified intention-to-treat analysis included data from 283 (RDG group: n = 141) (LDG 142)....
Abstract Immunosuppressive molecules are extremely valuable prognostic biomarkers across different cancer types. However, the diversity of immunosuppressive makes it very difficult to accurately predict clinical outcomes based only on a single molecule. Here, we establish comprehensive immune scoring system (ISS GC ) 6 ligands (NECTIN2, CEACAM1, HMGB1, SIGLEC6, CD44, and CD155) using LASSO method improve accuracy provide an additional selection strategy for adjuvant chemotherapy gastric...
Abstract Background BATF2, also known as SARI, has been implicated in tumor progression. However, its role, underlying mechanisms, and prognostic significance human gastric cancer (GC) are elusive. Methods We obtained GC tissues corresponding normal from 8 patients identified BATF2 a downregulated gene via RNA-seq. qRT-PCR western blotting were applied to examine levels tissues. The value of was elucidated using tissue microarray IHC analyses two independent cohorts. functional roles...
Indocyanine green (ICG) fluorescence imaging-guided lymphadenectomy has been demonstrated to be effective in increasing the number of lymph nodes (LNs) retrieved laparoscopic gastrectomy for gastric cancer (GC). Previously, we reported primary outcomes and short-term secondary a phase 3, open-label, randomized clinical trial (NCT03050879) investigating use ICG image-guided patients with potentially resectable GC. Patients were randomly (1:1 ratio) assigned either or non-ICG group. The...
Using a large sample of firms from 45 countries, we find that in countries with high-climate risk reduce their cash dividends but increasingly use share repurchases to make payouts. The evidence suggests substitute increase payout flexibility response heightened climate risk. Operating volatility and financial constraints are two channels through which affects firms' flexibility. Further analysis shows the effect on is more pronounced for vulnerable risk, where people concerned about...
To assess the effectiveness of indocyanine green (ICG)-guided lymph node (LN) dissection during laparoscopic radical gastrectomy after neoadjuvant chemotherapy (NAC) in patients with locally advanced gastric cancer (LAGC).
Abstract Objective The aim of this study was to investigate the prognostic value preoperative sarcopenia and systemic inflammation for patients with resectable gastric cancer (GC) develop a novel powerful score based on these factors. Materials Methods Patients GC who underwent radical gastrectomy between December 2009 2013 were included. A multivariate Cox regression analysis performed identify (SLMR) developed lymphocyte-monocyte ratio (LMR), its evaluated. Results In total, 1,167 included...
Neoadjuvant chemotherapy (NAC) is a standard treatment option for locally advanced gastric cancer (LAGC); however, the indications adjuvant (AC) in patients with LAGC who received NAC remain controversial.
Abstract LHPP, a histidine phosphatase, has been implicated in tumour progression. However, its role, underlying mechanisms, and prognostic significance human gastric cancer (GC) are elusive. Here, we obtained GC tissues corresponding normal from 48 patients identified LHPP as downregulated gene via RNA-seq. qRT-PCR western blotting were applied to examine levels tissues. The value of was elucidated using tissue microarray IHC analyses two independent cohorts. functional roles mechanistic...
UFM1 has been found to be involved in the regulation of tumor development. This study aims clarify role and potential molecular mechanisms invasion metastasis gastric cancer.Expression paired adjacent noncancerous tissues from 437 patients was analyzed by Western blotting, immunohistochemistry, realtime PCR. Its correlation with clinicopathological characteristics prognosis cancer analyzed. The effects on migration cells were determined wound trans-well assays, effect subcutaneous formation...
To assess the ability of Age-Adjusted Charlson Comorbidity Index (ACCI) to predict survival after radical gastrectomy in patients with gastric cancer (GC).Data from GC who underwent January 2008 December 2012 Fujian Medical University Union Hospital were retrospectively analyzed. Patients categorized into either high ACCI group or low based on effect long-term prognosis. 1:1 propensity score matching (PSM) was used reduce confounding bias. further analyze impact prognosis gastrectomy, a...
Whether the change of pre- and postoperative systemic inflammatory response (SIR) levels will affect prognosis gastric cancer (GC) is unclear. We aimed to investigate dynamic changes in SIR their prognostic value for GC. The clinicopathological data from 2257 patients who underwent radical gastrectomy between January 2009 December 2014 at Fujian Medical University Union Hospital (FMUUH) were analyzed. Perioperative reported as lymphocyte-monocyte ratio (LMR), neutrophil-lymphocyte (NLR),...