A5100435558- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- Gastrointestinal Tumor Research and Treatment
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Helicobacter pylori-related gastroenterology studies
- Pancreatic and Hepatic Oncology Research
- Inflammatory Biomarkers in Disease Prognosis
- Neuroendocrine Tumor Research Advances
- Esophageal Cancer Research and Treatment
- Cancer-related Molecular Pathways
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- Inflammatory mediators and NSAID effects
- Epigenetics and DNA Methylation
- Colorectal and Anal Carcinomas
- HER2/EGFR in Cancer Research
- Lung Cancer Research Studies
Union Hospital
2016-2025
Fujian Medical University
2016-2025
Jiangsu University
2016-2025
First People's Hospital of Kunshan
2016-2025
Nanjing Medical University
2020-2025
Suzhou Municipal Hospital
2023-2025
First Affiliated Hospital of Zhengzhou University
2020-2025
Peking University Shenzhen Hospital
2023-2025
Hainan Medical College Hospital
2023-2024
Guangzhou Medical University
2024
The application of indocyanine green (ICG) imaging in laparoscopic radical gastrectomy is the preliminary stages clinical practice, and its safety efficacy remain controversial.To investigate ICG near-infrared tracer-guided during D2 lymphadenectomy patients with gastric cancer.Patients potentially resectable adenocarcinoma (clinical tumor stage cT1-cT4a, N0/+, M0) were enrolled a prospective randomized trial at tertiary referral teaching hospital between November 2018 July 2019. Patients...
Abstract Prospective evidence regarding the combination of programmed cell death (PD)−1 and angiogenesis inhibitors in treating locally advanced gastric cancer (LAGC) is limited. In this multicenter, randomized, phase 2 trial (NCT04195828), patients with adenocarcinoma (clinical T2-4N + M0) were randomly assigned (1:1) to receive neoadjuvant camrelizumab apatinib combined nab-paclitaxel plus S-1 (CA-SAP) or chemotherapy SAP alone (SAP) for 3 cycles. The primary endpoint was major...
To study the historical global incidence and mortality trends of gastric cancer predicted by 2035.
Abstract ErbB2 overexpression in breast tumors results increased metastasis and angiogenesis reduced survival. To study signaling mechanisms angiogenesis, we did a spontaneous assay using MDA-MB-435 human cancer cells stably transfected with constitutively active kinase (V659E), kinase-dead mutant of (K753M), or vector control (neo). Mice injected V659E had incidence tumor microvessel density than mice K753M control. Increased vivo from the transfectants paralleled angiogenic potential...
Background: Tumor PD-L1 levels have predictive value in PD-1/PD-L1 checkpoint blockade therapies, yet biopsies can only provide baseline information. Whether expression on circulating tumor cells (CTCs) could serve as an alternative biomarker is of great interest. Design: We established immunofluorescence assay for semi-quantitative assessment the CTCs with four categories (PD-L1negative, PD-L1low, PD-L1medium and PD-L1high). 35 patients different advanced gastrointestinal tumors were...
Abstract Immunosuppressive molecules are extremely valuable prognostic biomarkers across different cancer types. However, the diversity of immunosuppressive makes it very difficult to accurately predict clinical outcomes based only on a single molecule. Here, we establish comprehensive immune scoring system (ISS GC ) 6 ligands (NECTIN2, CEACAM1, HMGB1, SIGLEC6, CD44, and CD155) using LASSO method improve accuracy provide an additional selection strategy for adjuvant chemotherapy gastric...
Abstract Background BATF2, also known as SARI, has been implicated in tumor progression. However, its role, underlying mechanisms, and prognostic significance human gastric cancer (GC) are elusive. Methods We obtained GC tissues corresponding normal from 8 patients identified BATF2 a downregulated gene via RNA-seq. qRT-PCR western blotting were applied to examine levels tissues. The value of was elucidated using tissue microarray IHC analyses two independent cohorts. functional roles...
Indocyanine green (ICG) fluorescence imaging-guided lymphadenectomy has been demonstrated to be effective in increasing the number of lymph nodes (LNs) retrieved laparoscopic gastrectomy for gastric cancer (GC). Previously, we reported primary outcomes and short-term secondary a phase 3, open-label, randomized clinical trial (NCT03050879) investigating use ICG image-guided patients with potentially resectable GC. Patients were randomly (1:1 ratio) assigned either or non-ICG group. The...
Abstract Robotic surgery may be an alternative to laparoscopic for gastric cancer (GC). However, randomized controlled trials (RCTs) reporting the differences in survival between these two approaches are currently lacking. From September 2017 January 2020, 300 patients with cT1-4a and N0/+ were enrolled either robotic (RDG) or distal gastrectomy (LDG) group (NCT03313700). The primary endpoint was 3-year disease-free (DFS); secondary endpoints reported here overall (OS) recurrence patterns....
Diabetic nephropathy (DN) is one of the most serious complications in diabetic patients. And m6A modifications mediated by METTL3 are involved multiple biological processes. However, specific function and mechanism DN remains unclear. model mice were first established with streptozotocin, WISP1 expression was confirmed qRT-PCR. Then influences or/and on proliferation, migration, epithelial-mesenchymal transition (EMT) fibrosis-related proteins high glucose (HG)-induced HK2 cells or tested...
Background Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of many malignant tumors. However, ICI-induced hyper-immune activation causes cardiotoxicity. Traditional treatments such as glucocorticoids and immunosuppressants limited effectiveness may even accelerate tumor growth. This study aimed to identify approaches that effectively reduce cardiotoxicity simultaneously preserve or enhance antitumor immunity ICI therapy. Methods injection in melanoma-bearing C57BL/6J...
The contribution of the inflammatory mediator interleukin-17 (IL-17) in nonsmall cell lung cancer (NSCLC) malignancy has been reported literature. MicroRNA-181a-5p (miR-181a-5p) acts as a tumor suppressor which can regulate target gene at posttranscriptional level. Our study aimed to investigate interaction between IL-17 and miR-181a-5p NSCLC.35 patients with NSCLC 24 COPD controls were selected examined our study. In vitro, H226 H460 lines exposed different doses (20, 40, 60, 80 ng/mL)...
Abstract Objective The aim of this study was to investigate the prognostic value preoperative sarcopenia and systemic inflammation for patients with resectable gastric cancer (GC) develop a novel powerful score based on these factors. Materials Methods Patients GC who underwent radical gastrectomy between December 2009 2013 were included. A multivariate Cox regression analysis performed identify (SLMR) developed lymphocyte-monocyte ratio (LMR), its evaluated. Results In total, 1,167 included...
Pulmonary fibrosis develops when myofibroblasts and extracellular matrix excessively accumulate in the injured lung, but what drives is not fully understood.Glycolysis has been linked to cell growth proliferation, several studies have shown enhanced glycolysis promotes pulmonary fibrosis.However, detailed describing this switch remain limited.Here, we identified that TGF-β1 effectively increased expression of circHIPK3 lung fibroblasts, inhibition attenuated activation, fibroblasts...