A5100330653- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Neural dynamics and brain function
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Fatigue and fracture mechanics
- Occupational and environmental lung diseases
- Oral microbiology and periodontitis research
- Viral Infections and Vectors
- Hearing Loss and Rehabilitation
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neuroscience and Music Perception
- Knee injuries and reconstruction techniques
- Muscle Physiology and Disorders
- Cancer Mechanisms and Therapy
- Graphene and Nanomaterials Applications
- Antimicrobial Peptides and Activities
- Music Therapy and Health
- RNA modifications and cancer
- Tuberculosis Research and Epidemiology
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- Liver Disease Diagnosis and Treatment
- Big Data Technologies and Applications
Huazhong University of Science and Technology
2019-2025
Tongji Hospital
2024-2025
Capital Medical University
2019-2025
Nanjing Medical University
2018-2025
Yangtze Normal University
2022-2025
Universidade de Vigo
2025
Beijing Anding Hospital
2019-2024
Beijing Tongren Hospital
2022-2024
Zhongnan Hospital of Wuhan University
2024
Wuhan University
2024
Silicosis is one of the typical forms pneumoconiosis characterized by abnormal proliferation fibroblasts and deposition extracellular matrix. Recent findings have shown that microRNAs circular RNAs (circRNAs) are implicated in many diseases. However, function noncoding pulmonary fibrosis remain to be elucidated. Here, miR-7 was found significantly decreased silica-treated epithelial cells as well fibrotic lung tissues mice. Elevated expression via agomir injection relieved vivo. Further...
Aberrant epidermal growth factor receptor (EGFR) activation is observed in over 50% of cases adult glioblastoma (GBM). Nevertheless, EGFR antibodies are ineffective clinical GBM treatment, suggesting the existence redundant mechanisms. Whether circular RNA (circRNA) encodes a protein involved EGFR-driven remains unclear. We reported an unexpected mechanism which (circ-EGFR) novel variant to sustained activation.We used RNA-seq, Northern blot, and Sanger sequencing confirm circ-EGFR....
Circular RNA (circRNA) are single‐stranded with covalently closed 3′ and 5′ ends, many recognized to be involved in human diseases as gene regulators, typically by interacting other RNA. CircFNDC3B is a circRNA formed back‐splicing of exons 5 6 the FNDC3B gene. was recently implicated renal carcinoma, gastric bladder cancer. However, expression levels circFNDC3B its role colorectal cancer (CRC) remain unclear. Expression TIMP3 CRC tissues cell lines were found low, whereas microRNA...
CircRNAs have garnered significant interest in recent years due to their regulation human tumorigenesis, yet, the function of most glioma-related circRNAs remains unclear.In this study, using RNA-Seq, we screened differentially regulated glioma, comparison non-tumor brain tissue.Loss-and gain-of-function strategies were used assess effect circCDK14 on tumor progression both vitro and vivo.Luciferase reporter, RNA pull-down fluorescence situ hybridization assays carried out validate...
Despite the fact that people make decisions for others as often they themselves, little is known about how are different from those made self. In two experiments, we investigated effect of social distance (i.e., making oneself, a friend, or stranger) on risk preferences in both gain and loss situations. We found were more averse situations when themselves than stranger (Studies 1 2), but equally their friends (Study 2). However, seeking well stranger, Furthermore, was stronger Mediation...
Pulmonary fibrosis develops when myofibroblasts and extracellular matrix excessively accumulate in the injured lung, but what drives is not fully understood.Glycolysis has been linked to cell growth proliferation, several studies have shown enhanced glycolysis promotes pulmonary fibrosis.However, detailed describing this switch remain limited.Here, we identified that TGF-β1 effectively increased expression of circHIPK3 lung fibroblasts, inhibition attenuated activation, fibroblasts...
The mechanisms underlying the effects of electroconvulsive therapy (ECT) in major depressive disorder (MDD) are not fully understood. Resting-state functional magnetic resonance imaging (rs-fMRI) is a new tool to study brain stimulation interventions, particularly ECT. authors aim investigate ECT MDD by rs-fMRI. They used rs-fMRI measure changes first-episode, treatment-naive patients (n = 23) immediately before and then following 8 sessions (brief-pulse square-wave apparatus, bitemporal)....
Fracture healing is a complex process involving various cell types, cytokines, and mRNAs. Here, we report the roles of circRNA AFF4/miR-7223-5p/PIK3R1 axis during fracture healing. We found that increased expression PIK3R1 directly associated with augmented proliferation decreased apoptosis MC3T3-E1 cells. Furthermore, miR-7223-5p targeted PI3KR1 inhibited while promoting apoptosis. CircRNA AFF4 acted as sponge miR-7223-5p, thereby inhibiting Local injection into femoral sites promoted in...
An increasing number of studies have demonstrated that circular RNAs (circRNAs), as promising therapeutic targets, are essential for diverse human diseases, especially cancer. However, the potential functions and complex mechanisms most circRNAs in osteosarcoma (OS) still not fully elucidated. In present study, we obtained expression profile from a GEO database (GSE96964) identified hsa_circ_0000073 highly expressed candidate OS. Overexpression accelerated proliferation, migration, invasion...
Baicalein has a significant anti-cancerous function in the treatment of cervical cancer (CC). Its functional mechanism regarding circular RNA (circRNA) hippocampus abundant transcript 1 (circHIAT1) and microRNA-19a-3p (miR-19a-3p) was explored this research.CC cell viability colony formation were determined using Cell Counting Kit-8 (CCK-8) assay. cycle progression apoptosis analyzed via flow cytometry. Protein markers cycle, protein kinase B/mammalian target rapamycin (AKT/mTOR) pathway...
Astragaloside IV (AS-IV) is an inartificial saponin separated from astragalus membranaceus, which has exhibited key anti-tumor regulation in some cancers. Circular RNAs (circRNAs) are important regulators malignant development of gastric cancer (GC). Herein, we focused on the molecular mechanism AS-IV with circRNA dihydrolipoamide S-succinyltransferase (circDLST) GC. CircDLST, microRNA-489-3p (miR-489-3p), and eukaryotic translation initiation factor 4A1 (EIF4A1) levels were detected by...
Pulmonary fibrosis is a growing clinical problem that develops as result of abnormal wound healing, leading to breathlessness, pulmonary dysfunction and ultimately death. However, therapeutic options for are limited because the underlying pathogenesis remains incompletely understood. Circular RNAs, key regulators in various diseases, remain poorly understood induced by silica.We performed studies with fibroblast cell lines silica-induced mouse models. The expression circZNF609, miR-145-5p,...
Glucocorticoids (GCs) are frequently used to treat many of the acute disease manifestations associated with inflammatory and autoimmune disorders. However, Toll-like receptor (TLR) pathway-activated plasmacytoid dendritic cells (pDCs) resistant GC-induced apoptosis, which leads inefficiency GCs in treatment type I interferon-related diseases, such as systemic lupus erythematosus (SLE). Therefore, compounds promoting pDC apoptosis may be helpful for improving efficacy GCs. In this study, we...
Background: Due to its impairment in patients with schizophrenia, mismatch negativity (MMN) generation has been identified as a potential biomarker for identifying primary impairments auditory sensory processing. This study aimed investigate the dysfunctional differences different MMN deviants and evoked theta power first-episode schizophrenia (FES) chronic (CS). Methods: We measured frequency duration from 40 FES, CS, healthy controls (HC). Evoked was analyzed by event-related spectral...
Paclitaxel is an effective chemotherapeutic agent for the treatment of cancer patients. Accumulating evidence suggests that circular RNAs (circRNAs) play critical roles in occurrence and development human cancers. However, there are few studies on interactions between paclitaxel circRNAs hepatocellular carcinoma (HCC).Cell counting kit-8 (CCK-8) assay colony formation were conducted to determine cell proliferation. Cell apoptosis was assessed by flow cytometry. The expression levels circRNA...
Circular RNAs (circRNAs) are non-coding forming closed-loop structures, and their aberrant expression may lead to disease. However, the potential network of circRNA‑associated competing endogenous RNA (ceRNA) involved in nonvalvular persistent atrial fibrillation (NPAF) has not been previously reported. In present study, four left appendages (LAA) patients with NPAF normal LAAs were examined via sequencing, functions investigated bioinformatics analysis. The circRNA‑enriched genes analyzed...
Spinal cord injury (SCI) is mostly caused by trauma. As primary mechanical unavoidable, a focus on the underlying molecular mechanisms of SCI-induced secondary necessary to develop promising treatments for patients with SCI. tRNA-derived small RNA (tsRNA) novel class short, non-coding RNA, possessing potential regulatory functions in various diseases. However, functional roles tsRNAs traumatic SCI have not been determined yet. We used combination sequencing, quantitative reverse...