A5101640938- Osteoarthritis Treatment and Mechanisms
- Cancer-related molecular mechanisms research
- Spinal Cord Injury Research
- Circular RNAs in diseases
- Quantum Information and Cryptography
- Spine and Intervertebral Disc Pathology
- Quantum and electron transport phenomena
- Inflammatory mediators and NSAID effects
- Cerebral Palsy and Movement Disorders
- Epigenetics and DNA Methylation
- Advanced Thermodynamics and Statistical Mechanics
- Central Venous Catheters and Hemodialysis
- Quantum Mechanics and Applications
- Stroke Rehabilitation and Recovery
- Cardiac Arrhythmias and Treatments
- Urticaria and Related Conditions
- Traditional Chinese Medicine Analysis
- Diabetic Foot Ulcer Assessment and Management
- Quantum Computing Algorithms and Architecture
- Sepsis Diagnosis and Treatment
- Galectins and Cancer Biology
- Umberto Eco and Semiotics
- Ginger and Zingiberaceae research
- Apelin-related biomedical research
- Chronic Kidney Disease and Diabetes
Southern University of Science and Technology
2022-2025
Beijing Academy of Quantum Information Sciences
2025
Shenzhen Children's Hospital
2022-2025
Quantum (Australia)
2024
Shandong First Medical University
2020-2024
Weatherford College
2023
Taian City Central Hospital
2019
Shenzhen Bao'an District People's Hospital
2019
Southern Medical University
2013-2016
Guangdong General Hospital
2013
Diabetic nephropathy (DN) is one of the most serious complications in diabetic patients. And m6A modifications mediated by METTL3 are involved multiple biological processes. However, specific function and mechanism DN remains unclear. model mice were first established with streptozotocin, WISP1 expression was confirmed qRT-PCR. Then influences or/and on proliferation, migration, epithelial-mesenchymal transition (EMT) fibrosis-related proteins high glucose (HG)-induced HK2 cells or tested...
Abstract Implementing quantum algorithms on realistic devices requires translating high-level global operations into sequences of hardware-native logic gates, a process known as compiling. Physical limitations, such constraints in connectivity and gate alphabets, often result unacceptable implementation costs. To enable successful near-term applications, it is crucial to optimize compilation by exploiting the capabilities existing hardware. Here we implement resource-efficient construction...
The complexity of the human intervertebral disc (IVD) has hindered elucidation microenvironment and mechanisms underlying IVD degeneration (IVDD). Here we determined landscapes nucleus pulposus (NP), annulus fibrosus (AF), immunocytes in by scRNA-seq. Six NP subclusters seven AF were identified, whose functional differences distribution during different stages (Pfirrmann I-V) investigated. We found MCAM+ progenitor AF, as well CD24+ MKI67+ NP, forming a lineage trajectory from CD24+/MKI67+...
This study aimed to investigate the role of long non-coding RNA (lncRNA) maternally expressed 3 (MEG3) and related molecular mechanisms, in osteoarthritis (OA).Cartilage tissues OA patients healthy volunteers were isolated cultured. After transfection with appropriate constructs, chondrocytes classified into Blank, pcDNA3.1-NC, pcDNA3.1-MEG3, si-NC, si-MEG3, pcDNA3.1-NC + mimics NC, pcDNA3.1-MEG3 miR-361-5p groups. qRT-PCR was used detect expression MEG3, FOXO1. Western blot, luciferase...
Background . Intervertebral disc degeneration (IVDD) is one of the major causes low back pain and motor deficiency. Nucleus pulposus (NP) plays a key role in process IVDD. The mechanical biological interactions involved NP have not been elucidated. present study aimed at investigating effect mechanism cyclic stretch regulating function cells. Methods cells were subjected to tensile stress (10% deformation) 0.1 Hz for 8640 cycles. Cell proliferation was conducted through MTT assay. cell cycle...
Superconducting qubits are a promising platform for building fault-tolerant quantum computers, with recent achievement showing the suppression of logical error increasing code size. However, leakage into noncomputational states, common issue in practical systems including superconducting circuits, introduces correlated errors that undermine correction (QEC) scalability. Here, we propose and demonstrate reduction scheme utilizing tunable couplers, widely adopted ingredient large-scale...
<title>Abstract</title> Quantum metrology has emerged as a powerful tool for timekeeping, field sensing, and precision measurements within fundamental physics. With the advent of distributed quantum metrology, its capabilities have been extended to probing spatially parameters across networked systems. However, generating necessary non-local entanglement remains significant challenge, inherent incompatibility in multi-parameter estimation affects ultimate performance. Here we use...
Fock-state lattices, composed of photon number states with infinite Hilbert space, have emerged as a promising platform for simulating high-dimensional physics due to their potential extend into arbitrarily high dimensions. Here, we demonstrate the construction multidimensional lattices using superconducting quantum circuits. By controlling artificial gauge fields within internal structures, investigate flux-induced extreme localization dynamics, such Aharonov-Bohm caging, extending from 2D...
Ginsenoside Rg3 is an active saponin isolated from ginseng, which can reduce renal inflammation. However, the role and mechanism of in diabetic kidney disease (DKD) are far being studied.
Introduction Pulmonary alveolar proteinosis (PAP) is a rare disease in infancy characterized by the accumulation of lipoprotein material within alveoli, leading to impaired gas exchange, ventilation-perfusion mismatch, and, severe cases, respiratory failure that may result death. Treatment options include medical therapy and whole lung lavage (WLL), typically requiring isolation techniques or extracorporeal membrane oxygenation. Previous studies have reported application several pediatric...
Objective. Cognitive impairment is considered to be an important complication of spinal cord injury (SCI), but its underlying mechanism remains unclear. The purpose this study explore whether serum CCL21 can used as a potential biomarker cognitive in SCI. Methods. In Neck-Shoulder and Lumbocrural Pain Hospital, Shandong First Medical University & Academy Sciences, hospitalized or treated acute SCI patients were included the group (SCI). At same time, normal control (NC) matching age sex...
Hypertensive‐induced renal damage (HRD) is an important public health and socioeconomic problem worldwide. The herb pair Radix Astragali ‐ (RA‐) Salviae Miltiorrhizae (RS) a common prescribed herbal formula for the treatment of HRD. However, underlying mechanisms are unclear. purpose our study to explore mechanism combination (RA) ameliorating HRD by regulation sympathetic nerve. Thirty 24‐week‐old spontaneously hypertensive rats (SHRs) as experimental group were randomly divided into RA...
Knee osteoarthritis (KOA) is the most common joint disease worldwide and, with progression of an aging population, one important causes disability worldwide. Its main symptoms include articular cartilage damage, periarticular pain, swelling, and stiffness. Intra-articular (IA) injections offer many advantages over systemic administration surgical treatment, including direct action on target to improve local bioavailability, reduce toxicity, lower costs. This study analyzed KOA...
Astragaloside IV (AS IV) and tanshinone (TS IIA) are the main natural components of Salvia miltiorrhiza Radix Astragali, respectively. The amalgam TS IIA AS has potential therapeutic value in many inflammation-related diseases. However, aftereffect for lumbar disc herniation is not clear. Although function miR-223 JAK/STAT pathway unknown, it particularly expressed human degenerative nucleus pulposus cells. This study investigated efficacy combined application treatment intervertebral cells...
Objective. Spinal cord injury (SCI) has become popular in recent years, and cognitive decline is a common complication. Adiponectin protein hormone involved the course of many diseases, but its relationship with SCI not yet been elucidated. The purpose our prospective study to explore whether adiponectin can be used as biomarker SCI. Methods. A total 64 healthy volunteers 92 patients acute were recruited by us. Serum levels, demographic data (age gender), lifestyle (smoking drinking),...
Objective. Angiopoietin-like protein 4 (ANGPTL4), encoding a glycosylated secreted protein, has been reported to be closely related many kinds of diseases, including diabetes, tumor, and some musculoskeletal pathologies, such as rheumatoid arthritis, osteoarthritis, osteoporosis. The aim the current study is investigate role ANGPTL4 in intervertebral disc degeneration analyze association expression with Pfirrmann grades. Methods. A total 162 nucleus pulposus tissues were collected from...
Background. Spinal cord injury (SCI) has high incidence globally and is frequently accompanied by subsequent cognitive decline. Accurate early risk-categorization of SCI patients for decline using biomarkers can enable the timely application appropriate neuroprotective measures development new agents management SCI-associated Neuropeptide FF an endogenous neuropeptide with a multitude functions associated neuroinflammatory processes. This prospective study investigated predictive value serum...
Background. Astragalus membranaceus (Huang-qi, AM) and Angelica sinensis (Dang-gui, AS) are common Chinese herbal medicines have historically been used in spinal cord injury (SCI) therapies. However, the underlying molecular mechanisms of AM&AS remain little understood. The purpose this research was to explore bioactive components treating SCI according network pharmacology docking approach. Methods. active ingredients were first searched from Traditional Medicine Systems Pharmacology...
Objective. Interleukin-37 (IL-37) is a new cytokine that naturally inhibits inflammation. Inflammation plays an important role in acute spinal cord injury (SCI). The purpose of this study to check whether serum IL-37 can be used as clinical predictor SCI. Methods. All subjects underwent venipuncture within 24 hours enrollment obtain peripheral blood and then centrifuged serum. concentration was determined by enzyme-linked immunosorbent assay (ELISA). One month after the injury, American...
It has previously been demonstrated that bradykinin receptor B1 (B1R) agonists evoke an itch-related scratching response in inflamed skin via the receptor; however, mechanisms responsible for this abnormal itch sensation remain unclear. Therefore, present study utilized a complete Freund's adjuvant (CFA)-induced mouse model of inflammation to elucidate responsible. Over period 30 min, behavior was quantified by number hind limb scratches area surrounding drug injection site on neck....
Objective . Leucine‐rich α 2 glycoprotein 1 (LRG1) is a novel cytokine, which believed to be involved in the inflammatory process of series diseases. However, relationship between LRG1 and spinal cord injury (SCI) has not been reported. The purpose our study determine predictive value for prognosis pediatric SCI (PSCI). Methods This recruited 64 patients with confirmed PSCI 40 healthy controls at Foshan Traditional Chinese Medicine Hospital from January 2016 December 2020. clinical...