A5017829182- Connective tissue disorders research
- MicroRNA in disease regulation
- Bone and Dental Protein Studies
- Bone Metabolism and Diseases
- Circular RNAs in diseases
- Hepatitis B Virus Studies
- RNA Research and Splicing
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Pluripotent Stem Cells Research
- Bone health and treatments
- Rheumatoid Arthritis Research and Therapies
- Cancer-related molecular mechanisms research
- Alkaline Phosphatase Research Studies
- Hepatitis C virus research
- Cancer-related gene regulation
- Heterotopic Ossification and Related Conditions
- Respiratory viral infections research
- interferon and immune responses
- Virus-based gene therapy research
- Bacteriophages and microbial interactions
- Cancer, Lipids, and Metabolism
- Metabolism and Genetic Disorders
- Renal and related cancers
- Spondyloarthritis Studies and Treatments
Shandong First Medical University
2016-2025
Academy of Medical Sciences
2012-2025
Shandong Provincial QianFoShan Hospital
2021-2025
Nantong University
2024
National Health and Family Planning Commission
2020-2022
Second Hospital of Shanxi Medical University
2017-2022
Shanxi Medical University
2018-2022
University of Jinan
2013-2020
Biotechnology Research Center
2008-2020
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2015
Mineralizing osteoblasts (MOBs) can release exosomes, although the functional significance remains unclear. In present study, we demonstrate that exosomes derived from mineralizing pre‐osteoblast MC3T3‐E1 cells promote bone marrow stromal cell (ST2) differentiation to osteoblasts. We reveal MOB‐derived significantly influence miRNA profiles in recipient ST2 cells, and these changes tend activate Wnt signaling pathway by inhibiting Axin1 expression increasing β‐catenin expression. also...
Abstract Peptidylarginine deiminase type 4 (PAD4/PADI4) posttranslationally converts peptidylarginine to citrulline, in a process known as citrullination. Evidence suggests that PAD4 plays an essential role pathogenesis of rheumatoid arthritis (RA). RA synovium has many features common with tumor tissues, including abnormal cell proliferation, extensive fibrin deposition, high coagulation activity, and extreme angiogenesis. The purpose the present study was investigate expression various...
Patients having experienced the ischemia-reperfusion process are particularly vulnerable to subsequent heart attacks because this can induce myocardial fibrosis, hallmarked by release of reactive oxygen species and some proteases, such as cathepsin G, into circulating blood. If these risk indicators be monitored from peripheral serum, early diagnosis intervention may become a reality. For purpose, we have designed an assay free copper ions G in serum using only synthetic small molecules...
Rheumatoid arthritis (RA) is a progressive disease including four stages, where gut microbiome associated with pathogenesis. We aimed to investigate stage-specific roles of microbial dysbiosis and metabolic disorders in RA.
This study utilizes CiteSpace (version 6.2.R3) to visually analyze literature related rare diseases, summarizing the current research status and hotspots in field. The goal was provide broader perspectives references for researchers diseases. A comprehensive search relevant diseases domain conducted through China Knowledge Network (CNKI) Web of Science (WOS), spanning years 1985 2024. Then, software utilized create a visual map annual publication volume, authors, institutions, keywords,...
Onset of castration-resistance prostate cancer (CRPC) after long-term androgen deprivation therapy remains a major obstacle in the treatment cancer. The peptidylarginine deiminase PADI2 has been implicated chronic inflammatory diseases and Here we show that is an androgen-repressed gene upregulated CRPC. expression was required for survival cell-cycle progression cells, promoted proliferation cells under androgen-deprived or castration conditions vitro vivo Cytoplasmic protected receptor...
Amyotrophic Lateral Sclerosis (ALS) is a muscle-bone degenerative disease, which lacks specific index for diagnosis. In our previous studies, we found that exosomes mediated the interaction mechanism between muscle and bone at cellular level, myoblast can transfer miR-27a-3p to promote osteoblast mineralization. Therefore, suppose expression of in serum ALS patients also changes. this study, used healthy human as sample find out conditions methods extraction detection. Then through...
Calvaria from neonatal mouse and rat is ideal resource for osteoblasts but can be easily contaminated by other cells such as fibroblasts. Here, we established a protocol isolation purification of primary osteoblast enzyme sequential digestion differential adhesion. In addition, compared the phenotypic functional traits which are commonly employed in studies. The method applied equally to was corroborated its feasibility validity. results also provided us evidences experiments choosing...
Abstract The porous structure is crucial in bone tissue engineering for promoting osseointegration. Among various structures, triply periodic minimal surfaces (TPMS) ‐Gyroid has been extensively studied due to its superior mechanical and biological properties. However, previous studies have given limited attention the impact of unit cell size on performance scaffolds. In this research, four TPMS‐Gyroid titanium scaffolds with different sizes (TG15, TG20, TG25, TG30) are fabricated using...
Objective. A proteomic approach was applied to discover novel rheumatoid arthritis (RA)-specific proteins by comparing the expression profiles of synovial membranes from patients with RA, osteoarthritis (OA), and ankylosing spondylitis (AS). Methods. Synovial tissues were collected RA (n = 10), OA or AS 6), healthy controls matched for age sex. Proteins separated 2-dimensional polyacrylamide gel electrophoresis, significantly increased in samples subject matrix-assisted laser...
// Lin Wang 1 , Guanhua Song 2 Weiwei Tan 3 Mei Qi Lili Zhang Jonathan Chan 4 Jindan Yu 5 Jinxiang Han Bo 3, 6 Research Center for Medicinal Biotechnology, Key Laboratory Rare & Uncommon Diseases of Shandong Province, Academy Sciences, Jinan, China Institute Basic Medicine, Medical Department Pathology, University School, Immunology, Toronto, Ontario, Canada Division Hematology/Oncology, Northwestern Feinberg School Chicago, IL, USA Qilu Hospital, Correspondence to: Han, e-mail:...
Acute respiratory infections (ARIs) are a great public health challenge globally. The prevalence of viruses in patients with ARIs attending at different hospital settings is fully undetermined. Laboratory-based surveillance for was conducted inpatient and outpatient 11 hospitals North China. first 2–5 were recruited each weekly from 2012 through 2015. presence screened by PCR assays. determined compared between settings. A total 3487 hospitalized cases 6437 outpatients/Emergency Department...
Abstract Mounting evidence is revealing that heavy metals can incur disordered bone homeostasis, leading to the development of degenerative diseases, including osteoporosis, osteoarthritis, disk disease, and osteomalacia. Meanwhile, metal‐induced anemia has been found be intertwined with diseases. However, relationship interplay among these adverse outcomes remain elusive. Thus, it importance shed light on modes action (MOAs) outcome pathways (AOPs) responsible for diseases under exposure...
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic and symmetric in-flammation. Our previous research revealed an imbalance in the gut flora of RA patients showed that certain microbiota can accelerate progression enhancing vitamin C degradation. However, it unclear whether supplementation could improve to prevent development interfering with gut-joint axis. In this work, we aimed evaluate effects regulating elucidate its potential role onset mouse model,...
Osteoclasts secrete factors that may promote mesenchymal stem cell mineralization in vitro. Fibroblasts are the most common cells connective tissue and involved process of exotic ossification many diseases such as ankylosing spondylitis. The purpose this study was to investigate whether osteoclast-like would induce osteogenic differentiation fibroblasts In present study, (OLCs) were generated by CD14+ from human peripheral blood. primarily cultured spinal ligaments. After treatment with...
One of the most distinctive features ankylosing spondylitis (AS) is new bone formation and resorption at sites chronic inflammation. Previous studies have indicated that hyperplasia inflammation synovial tissues are significantly related to pathogenic process AS. The present study used a proteomic approach identify novel AS-specific proteins by simultaneously comparing expression profiles membranes from patients with AS, rheumatoid arthritis (RA) osteoarthritis (OA). Synovial were collected...
Ankylosing spondylitis (AS) is characterized by abnormal bone formation in the spine and sacroiliac joints. In vitro assays demonstrate that carbonic anhydrase I (CA1) promotes calcium precipitation. This study investigated function of CA1 for bio-mineralization determined if common polymorphisms gene might contribute to AS risk.Calcification was induced Saos-2 cells, a human osteosarcoma cell line, with ascorbic acid β-glycerophosphate. Calcification Alizarin Red-S (AR-S) staining....