A5074659129- Spondyloarthritis Studies and Treatments
- Psoriasis: Treatment and Pathogenesis
- Rheumatoid Arthritis Research and Therapies
- Autoimmune and Inflammatory Disorders Research
- Autoimmune Bullous Skin Diseases
- Urticaria and Related Conditions
- Skin Diseases and Diabetes
- Cutaneous lymphoproliferative disorders research
- Autoimmune and Inflammatory Disorders
- Lymphoma Diagnosis and Treatment
- Rocket and propulsion systems research
- Health Systems, Economic Evaluations, Quality of Life
- Computational Fluid Dynamics and Aerodynamics
- Microscopic Colitis
- Inflammasome and immune disorders
- Bone and Joint Diseases
- Drug-Induced Adverse Reactions
- Sympathectomy and Hyperhidrosis Treatments
- Winter Sports Injuries and Performance
- Chemotherapy-related skin toxicity
- Eosinophilic Disorders and Syndromes
- Cutaneous Melanoma Detection and Management
- Dermatologic Treatments and Research
- Immunodeficiency and Autoimmune Disorders
- Laser Applications in Dentistry and Medicine
University of British Columbia
2016-2024
British Columbia Children's Hospital
2024
Sir Charles Gairdner Hospital
2010-2024
Research Canada
2019-2024
Queen Mary University of London
2024
University of Toronto
2010-2018
The Scarborough Hospital
2018
Center for Clinical and Cosmetic Research
2017-2018
University Health Network
2018
Loma Linda University
2017
// Lin Wang 1 , Guanhua Song 2 Weiwei Tan 3 Mei Qi Lili Zhang Jonathan Chan 4 Jindan Yu 5 Jinxiang Han Bo 3, 6 Research Center for Medicinal Biotechnology, Key Laboratory Rare & Uncommon Diseases of Shandong Province, Academy Sciences, Jinan, China Institute Basic Medicine, Medical Department Pathology, University School, Immunology, Toronto, Ontario, Canada Division Hematology/Oncology, Northwestern Feinberg School Chicago, IL, USA Qilu Hospital, Correspondence to: Han, e-mail:...
Abstract Background/Objectives The high incidence of comorbidities in patients with psoriasis, significant impact on quality life and patients' dissatisfaction treatment led a European group to develop consensus position psoriasis goals. There is an evident need for similar goals A ustralia. aim this project was Australian that reflect the local environment. Methods panel 12 representatives drawn from across ustralia consisting nine dermatologists rheumatologist, dermatology nurse general...
The aeropropulsive performance characteristics of a scramjet and shock-induced combustion ramjet (shcramjet) are compared at flight Mach number 11 an altitude 34.5 km. vehicles share the same inlet type, fuel injection system, fuel/air equivalence ratio, mixing/combustor duct, methodology nozzle design, gridding technique. numerical simulation three-dimensional vehicle flowfields from tip to tail performed by window allocatable resolver for propulsion code, in which multispecies...
Venous thromboembolism (VTE), including pulmonary embolism (PE) and deep venous thrombosis (DVT), can be life threatening. An increased frequency of VTE has been found in inflammatory conditions. To date, evidence assessing whether this risk is also greater patients with ankylosing spondylitis (AS) scarce.Using the provincial British Columbia, Canada healthcare database that encompasses all residents within province, we conducted matched cohort analyses incident PE, DVT overall among cases...
Upadacitinib (UPA), a selective, reversible, oral Janus kinase (JAK)-1 inhibitor, was approved in 2019 Canada for the treatment of adults with moderately to severely active rheumatoid arthritis (RA). This phase 4 prospective study aimed characterise effectiveness UPA real-world population patients RA. Adults RA who initiated once daily (15 mg) and enrolled Canadian Real-Life post-marketing Observational Study assessing Effectiveness UPadacitinib treating (CLOSE-UP) completed 6-month...
There is an increasing emphasis on the early identification and treatment of ankylosing spondylitis (AS) which hallmark sacroiliitis. Patients with inflammatory bowel disease (IBD) are at increased risk AS often receive computed tomography (CT) scans their abdomen, affording clinicians opportunity to determine presence Previous studies using CT have relied only radiologist's gestalt or a nonvalidated adaptation modified New York criteria. Our aim assess prevalence sacroiliitis in IBD...
Sacroiliitis, an inflammatory arthropathy associated with ankylosing spondylitis (AS), is found in patients bowel disease (IBD) but may go undiagnosed. The aims of this study were to assess prevalence sacroiliitis IBD and determine association between clinical characteristics sacroiliitis. Inflammatory undergoing abdomino-pelvic computed tomography (CT) for any indication (2006–2015) identified. Using standardized CT scoring, was confirmed. Two blinded readers used a standardised model where...
The host restricts Salmonella enterica serovar Typhimurium infection of the gut via inflammasome-dependent sloughing infected epithelial cells. Here we determined that concurrent caspase 1/11-dependent release goblet cell-derived mucin, Muc2, into intestinal lumen also controls burdens in mice. increased mucins from cells cecum and nearby proximal colon, subsequent thickening protective mucus barrier layer distal were all dependent on cytokines interleukin (IL)-18 IL-22, as deficiencies...
Bowel bypass syndrome, also known as bowel-associated dermatitis arthritis has been described after a range of intestinal procedures. With the increasing trend in laparoscopic gastric surgery, we report an interesting case syndrome that developed 12 months following this procedure. A 49-year-old woman presented with ulcerating lesions and pustules on upper lower limbs, polyarthralgia, fevers joint effusions. Before development these symptoms she was well, no significant past medical or...
Biological therapy with tumour necrosis factor alpha antibodies continues to offer a life-changing option for range of autoimmune and inflammatory skin conditions. We present three cases sarcoidosis, refractory cutaneous disease successfully treated infliximab. A review the literature shows increased numbers sarcoidosis cleared infliximab therapy.
SUMMARY A 47‐year‐old man underwent liver transplantation for cirrhosis secondary to hepatitis C and alcoholism. This was complicated by primary donor dysfunction acute renal failure requiring dialysis. Gadolinium magnetic resonance cholangiopancreatography performed 2 weeks post transplant, a second successful transplant 1 week later. Shortly after this, the patient developed rapidly progressive erythematous plaques over his abdomen, lower upper limbs. There marked oedema skin induration....
Lichenoid keratosis (LK), also known as benign lichenoid or lichen planus‐like keratosis, is a solitary, pink to red‐brown scaly plaque representing host immunological response variety of precursor lesions. LK often misdiagnosed dermatological malignancy owing its clinical resemblance basal cell carcinoma (BCC) Bowen disease. We performed retrospective analysis the pathology records series lesions with reference demographic features and accuracy diagnosis. The from 2008 2009 263 consecutive...
Objective We aimed to assess the following: (1) frequency of axial spondyloarthritis (axSpA) according extra‐articular presentation and HLA‐B27 status, (2) clinical imaging features that distinguish axSpA from non‐axSpA, (3) impact magnetic resonance (MRI) on diagnosis classification axSpA. Methods The Screening for Axial Spondyloarthritis in Psoriasis, Iritis, Colitis (SASPIC) study enrolled patients two multicenter cohorts. Consecutive with undiagnosed chronic back pain attending...
Objective. To develop a screening tool for the identification of sacroiliitis on abdominal computed tomography (CT) scan. Methods. Variables including erosions (number and size), sclerosis (depths > 0.3 cm or 0.5 cm), ankylosis were identified through training exercise involving 12 CT scans containing sacroiliac joints. Two blinded readers read 24 from derivation cohort to propose identifying discriminating features sacroiliitis. A test 68 patients was used confirm utility this tool....
ABSTRACT A 57‐year‐old woman with prior exposure to bisphosphonates developed myalgia, proximal muscle weakness and lichenoid rash over the upper extremities face 3 days after infusion of zoledronic acid for management osteoporosis. The diagnosis dermatomyositis was made on basis clinical, laboratory histological findings. This is first report drug‐induced secondary acid.
Summary Infliximab is a chimeric anti‐tumour necrosis factor‐α antibody that has been demonstrated to have marked efficacy in the treatment of psoriasis. Seven patients with chronic plaque psoriasis were treated single‐dose intravenous infliximab (5 mg/kg), and Psoriasis Area Severity Index (PASI) Dermatology Life Questionnaire (DLQI) used as measure efficacy. There was an average improvement PASI scores 69% at 2 weeks post infusion. DLQI 61%. Four seven also seen 10 infusion sustained. All...
Abstract Background/Objectives Scalp dysesthesia is characterised by abnormal cutaneous sensations such as burning, stinging or itching of the scalp in absence objective dermatological findings. We hypothesised that unpleasant are result a sensory neuropathy secondary to cervical spine dysfunction and chronic tension pericranial muscles. The aim this pilot study was evaluate use an exercise protocol consisting range movement exercises, gentle mobilisation muscle stretches over 4 weeks....