A5100661537- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Cancer Cells and Metastasis
- Management of metastatic bone disease
- Nanoparticles: synthesis and applications
- Radiation Detection and Scintillator Technologies
- Cancer Immunotherapy and Biomarkers
- Endometrial and Cervical Cancer Treatments
- Alzheimer's disease research and treatments
- Medical Imaging Techniques and Applications
- Traditional Chinese Medicine Studies
- Graphene and Nanomaterials Applications
- Oral Health Pathology and Treatment
- Biofield Effects and Biophysics
- Pharmacological Effects of Natural Compounds
- Metastasis and carcinoma case studies
- Salivary Gland Disorders and Functions
- Carcinogens and Genotoxicity Assessment
- Natural product bioactivities and synthesis
- Salivary Gland Tumors Diagnosis and Treatment
- Neurological Disease Mechanisms and Treatments
- Microplastics and Plastic Pollution
- Heavy Metal Exposure and Toxicity
- Pancreatic and Hepatic Oncology Research
- Computational Drug Discovery Methods
Guangzhou University of Chinese Medicine
2010-2025
Changzhou University
2024
University of Cincinnati
2018-2024
Cincinnati Children's Hospital Medical Center
2020-2024
Fujian Medical University
2024
Yangzhou University
2021-2024
Zhangzhou Municipal Hospital of Fujian Province
2024
Gansu Provincial Hospital
2015-2024
University of Cincinnati Medical Center
2018-2022
National Center for Toxicological Research
2011-2020
To our knowledge, there have been no clinical trials of ultra-high-dose-rate radiotherapy delivered at more than 40 Gy/sec, known as FLASH therapy, nor first-in-human use proton FLASH.To assess the workflow feasibility and treatment-related toxic effects pain relief treatment sites.In FAST-01 nonrandomized trial, participants treated Cincinnati Children's/UC Health Proton Therapy Center underwent palliative to extremity bone metastases. Patients 18 years older with 1 3 painful metastases...
Despite the death rate of COVID-19 is less than 3%, fatality severe/critical cases high, according to World Health Organization (WHO). Thus, screening before symptom occurs effectively saves medical resources.
Abstract A paradigm shift is occurring in clinical oncology exploiting the recent discovery that short pulses of ultra-high dose rate (UHDR) radiation—FLASH radiotherapy—can significantly spare healthy tissues whilst still being at least as effective curing cancer radiotherapy conventional rates. These properties promise reduced post-treatment complications, improving patient access to proton beam and reducing costs. However, accurate dosimetry UHDR extremely complicated. This work presents...
Silver nanoparticles (Ag-NPs) have increasingly been used for coatings on various textiles and certain implants, the treatment of wounds burns, as a water disinfectant, in air-freshener sprays. The wide use Ag-NPs may potential human health impacts. In this study, mutagenicity 5-nm was evaluated mouse lymphoma assay system, modes action were assessed using standard alkaline enzyme-modified Comet assays gene expression analysis. Treatments L5178Y/Tk(+/-) cells with uncoated resulted...
A brain-targeted drug delivery nanoplatform based on graphene oxide could overcome the blood–brain barrier for treatment of Parkinson's disease.
To provide ultrahigh dose rate (UHDR) pencil beam scanning (PBS) proton dosimetry comparison of clinically used plane-parallel ion chambers, PTW (Physikalisch-Technische Werkstaetten) Advanced Markus and IBA (Ion Beam Application) PPC05, with a graphite calorimeter in support first in-human FLASH clinical trial.
The safety and efficacy of neoadjuvant immunochemotherapy (nICT) for locally advanced gastric cancer (LAGC) remain controversial.
Silver nanoparticles (Ag-NPs) are widely used in FDA regulated products. The physical-chemical properties of Ag-NPs characterized using various instruments. dose-dependent activity and body weight alterations evaluated after rats were exposed to Ag nanoparticles, suggesting a major human health risk, given the wide application silver nanomaterials.
Abstract The majority of cancer mortality is associated with metastasis. Epithelial‐to‐mesenchymal transition (EMT) a process by which cells attain migratory and invasive properties, eventually leading to Here, it shown that titanium dioxide nanoparticles (nano‐TiO 2 ), common food additive, can induce the EMT in colorectal cells. Nano‐TiO exposure observed activate transforming growth factor‐β (TGF‐β)/mitogen‐activated protein kinase (MAPK) wingless (Wnt) pathways, drive process. Similarly,...
Abstract Background Recent studies have suggested that the metastasis-associated colon cancer1 (MACC1) gene can promote tumor proliferation, invasion and metastasis through an upregulation of c-Met expression. However, its role in gastric cancer is controversial. Our study investigated expression MACC1 cancer, as well correlated this with clinicopathological parameters. Methods Expressions protein a sample 98 carcinoma adjacent nontumorous tissues were detected by immunohistochemistry. Their...
Ligustilide, the main lipophilic component of Radix angelicae sinensis, has been shown to ameliorate cognitive dysfunction in a few Alzheimer’s disease mouse models, but its mechanism is not fully understood. In this study, we employed 7-month-old APP/PS1 mice explore whether LIG able protect against progression. The Morris water maze and Y-maze test results showed that eight weeks intragastric administration (10 mg/kg, 40 mg/kg) every day improved memory deficit mice. thioflavin-S staining...
Over the past several decades, natural products with poly-pharmacological profiles have demonstrated promise as novel therapeutics for various complex diseases, including cancer. Berberine (PubChem CID: 2353), a soliloquies quaternary alkaloid, has been validated to exert powerful effects in many cancers. However, underlying molecular mechanism is not yet fully elucidated. In this study, we summarized of berberine against multiple cancers based on current available literatures. Furthermore,...
Abstract Background The emergence of targeted therapies and immunotherapy has broadened treatment options for patients with pancreatic ductal adenocarcinoma (PDAC). Despite this, traditional drug selection, predominantly relies on tumor markers clinical staging, underutilized these drugs due to ignoring patient genomic diversity. Patient-derived organoids (PDOs) corresponding patient-derived organoid xenograft (PDOX) models offer a way better understand address this. Methods In this study,...