A5059896775- Advanced Image Processing Techniques
- Cervical Cancer and HPV Research
- Radiomics and Machine Learning in Medical Imaging
- Image and Signal Denoising Methods
- Colorectal Cancer Screening and Detection
- Surgical Simulation and Training
- Image Processing Techniques and Applications
- Advanced Measurement and Detection Methods
- Gastrointestinal Bleeding Diagnosis and Treatment
- HER2/EGFR in Cancer Research
- Advanced Algorithms and Applications
- Breast Cancer Treatment Studies
- MRI in cancer diagnosis
- Nuclear Receptors and Signaling
- Reproductive tract infections research
- Genital Health and Disease
- Advanced Sensor and Control Systems
- Parkinson's Disease Mechanisms and Treatments
- Monoclonal and Polyclonal Antibodies Research
- Nerve injury and regeneration
- Soft Robotics and Applications
- Pressure Ulcer Prevention and Management
- Personality Traits and Psychology
- Kruppel-like factors research
- Social Robot Interaction and HRI
Fudan University
2023-2024
Central Hospital of Zibo
2024
The Affiliated Hospital to Changchun University of Chinese Medicine
2024
Changchun University of Chinese Medicine
2024
Shanghai Tenth People's Hospital
2024
Tongji University
2024
Shanghai University of Medicine and Health Sciences
2015-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2021-2023
China Pharmaceutical University
2022
Northwestern Polytechnical University
2021
Despite the death rate of COVID-19 is less than 3%, fatality severe/critical cases high, according to World Health Organization (WHO). Thus, screening before symptom occurs effectively saves medical resources.
α-Synuclein (α-syn) plays a prominent role in the degeneration of midbrain dopaminergic (mDA) neurons Parkinson9s disease (PD). However, only few studies on α-syn have been performed mDA <i>in vivo</i>, which may be attributed to lack transgenic mice that develop PD-like severe neurons. To gain mechanistic insights into α-syn-induced neurodegeneration, we generated new line tetracycline-regulated inducible overexpressed PD-related A53T missense mutation Here show mutant developed profound...
Parkinson's disease (PD), the most common degenerative movement disorder, is caused by a preferential loss of midbrain dopaminergic (mDA) neurons. Both α-synuclein (α-syn) missense and multiplication mutations have been linked to PD. However, underlying intracellular signalling transduction pathways α-syn-mediated mDA neurodegeneration remain elusive. Here, we show that transgenic expression PD-related human α-syn A53T mutation promoted calcineurin (CN) activity subsequent nuclear...
BACKGROUND High-mobility group box 1 (HMGB1) is an essential contributor towards initiation and progression of many kinds cancers. Nevertheless, our understanding the molecular etiology HMGB1-modulated vasculogenesis, as well invasion, breast cancer poor. This study explored HMGB1 expression in its role development spread malignancy. MATERIAL AND METHODS We enrolled 15 patients with who received primary surgery at Department Thyroid Breast Surgery hospital. was recorded analyzed. RESULTS Our...
Abstract Background Human papillomavirus (HPV) infection is the leading cause of genital diseases. It can a series cervical lesions. The distribution HPV genotypes indicates that increased prevalence high-risk (HR-HPV) positively correlated with severity In addition, persistent HR-HPV associated risk cancer. Considering latest approval homemade vaccine in China and distribution, this great significance for guiding vaccination work. Objective Our study’s purpose was to examine trends rate...
In the later stages of Parkinson's disease (PD), patients often manifest levodopa-induced dyskinesia (LID), compromising their quality life. The pathophysiology underlying LID is poorly understood, and treatment options are limited. To move toward filling this gap, intrinsic synaptic changes in striatal spiny projection neurons (SPNs) triggered by sustained elevation dopamine (DA) during were characterized using electrophysiological, pharmacological, molecular behavioral approaches. Our...
Image deblurring is one of the classical problems in image processing and computer vision. The vital task to restore high-quality with edge-preservation, details-protection, artifacts suppression. In order achieve ideal results, a nonblind method that combines total generalized variation (TGV) shearlet-based sparsity proposed. First, observed decomposed into two components: structures details by global gradient extraction scheme. Second, for structure component, TGV regularization utilized...
Triple-negative breast cancer (TNBC) is the most aggressive subtype and occurs in approximately 15-20% of diagnosed cancers. TNBC characterized by its highly metastatic recurrent features, as well a lack specific targets targeted therapeutics. Epidermal growth factor receptor (EGFR) expressed variety tumors, especially TNBC. LR004-VC-MMAE new EGFR-targeting antibody-drug conjugate produced our laboratory. This study aimed to evaluate antitumor activities against EGFR-positive further studied...
This paper investigates whether empathy towards an interactive trash bin, particularly induced by the bin's anthropomorphic appearance and behavior, affects people's evaluations of artifact their intention to use it recycle. We performed online survey in which 344 participants viewed a video showing person interacting with recycling bin one three conditions: non-interactive/control, non-anthropomorphic interactive, interactive. measured perceptions anthropomorphism animacy, anxiety enjoyment...
This paper presents a minimally invasive surgical robot system for endoluminal gastrointestinal endoscopy through natural orifices. In endoscopic surgery (MIGES), instruments need to pass narrow channels perform highly flexible tasks, imposing strict constraints on the size of while requiring it possess certain gripping force and flexibility. Therefore, we propose novel with advantages such as compact high precision. The consists an endoscope, two continuum mechanical arms diameters 3.4 mm...
Pancreatic cancer (PC) is considered as one of the deadliest cancers all over world. Germline and somatic BRCA1/2 mutations have been widely studied in breast ovarian carcinomas they found to enhance risk for disease progression. Olaparib, an oral poly(adenosine diphosphate-ribose)polymerase (PARP) inhibitor, has approved treatment strategy with any mutations. There a lack studies which focus on other BRCA-Mutation.This report describes patient whose presenting complaints were "Physical...
Herein, we first prepared a novel anti-TROP2 antibody-drug conjugate (ADC) hIMB1636-MMAE using hIMB1636 antibody chemically coupled to monomethyl auristatin E (MMAE) via Valine-Citrulline linker and then reported its characteristics antitumor activity. With DAR of 3.92, it binds specifically both recombinant antigen (KD ∼ 0.687 nM) cancer cells could be internalized by target selectively kill them with IC50 values at nanomolar/subnanomolar levels inducing apoptosis G2/M phase arrest. also...
Abstract Background Human papillomavirus (HPV) infection is currently the main cause of cervical cancer and precancerous lesions in female patients. By analyzing 6-year patient data from Shanghai Zhoupu Hospital China, we retrospectively analyzed epidemiological characteristics women to determine relationship between HPV genotype cytological test results. Methods From 2014 2019, 23,724 cases shedding were collected Shanghai, China. comparing results ThinPrep cytology (TCT), rate patients was...
Objective Examining the correct number of lymph nodes when diagnosing breast cancer invasion is still a problem. This work aimed to develop qualification model that estimates possibility missing and need be examined. Methods By analyzing node 303,760 samples with primary tumor stage examined positive from Surveillance, Epidemiology End Results database using beta-binomial model, should was quantified in different stages. In general, reduce less than 10%, 21 examined; thus, current median...
The lymph nodal invasion diagnosis is critical for therapeutic-decision and follows up in gastric cancer. However, the number of nodes to be examined still under controversy, model quantifying risk missing positive node currently not reported yet. We analyzed status 13,857 cancer samples with records primary tumor stage, surveillance, epidemiology, end results (SEER) database, fitting a beta-binomial model. need different stage were determined based on Overall, examining 11 reduces...
In robot-assisted surgical systems, instrument segmentation is a critical task that provides important information for surgeons to make informed decisions and ensure safety. However, current mainstream models often lack precise edges suffer from an excess of parameters, rendering their deployment challenging. To address these issues, this article proposes lightweight semantic model based on edge refinement efficient self-attention. The proposed utilizes densely connected network feature...
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