A5102759544- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Screening and Detection
- Colorectal and Anal Carcinomas
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Esophageal and GI Pathology
- Esophageal Cancer Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Treatments and Studies
- Ferroptosis and cancer prognosis
- Genetic factors in colorectal cancer
- Treatment of Major Depression
- Medical Imaging Techniques and Applications
- Sirtuins and Resveratrol in Medicine
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Diagnosis and Treatment
- Advanced Radiotherapy Techniques
- Metabolomics and Mass Spectrometry Studies
- Virus-based gene therapy research
- RNA Interference and Gene Delivery
- Glioma Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Pelvic and Acetabular Injuries
Zhengzhou University
2023-2025
Fujian Provincial Cancer Hospital
2010-2024
Fujian Medical University
2011-2024
Shanghai Jiao Tong University
2012
The efficacy of laparoscopic vs open surgery for patients with low rectal cancer has not been established.
<h3>Importance</h3> Apatinib is a novel treatment option for chemotherapy-refractory advanced gastric cancer (GC), but it has not been evaluated in patients with locally GC. <h3>Objective</h3> To investigate the effectiveness and safety of apatinib combined S-1 plus oxaliplatin (SOX) as neoadjuvant <h3>Design, Setting, Participants</h3> This multicenter, prospective, single-group, open-label, phase 2 nonrandomized controlled trial was conducted 10 centers southern China. Patients M0 either...
Dysregulated amino acid increases the risk for heart failure (HF) via unclear mechanisms. Here, we find that increased plasma tyrosine and phenylalanine levels are associated with HF. Increasing or by high-tyrosine high-phenylalanine chow feeding exacerbates HF phenotypes in transverse aortic constriction isoproterenol infusion mice models. Knocking down dehydrogenase abolishes effect of phenylalanine, indicating functions converting to tyrosine. Mechanistically, tyrosyl-tRNA synthetase...
BACKGROUND Depression is a prevalent affective disorder, but its pathophysiology remains unclear. Dysfunction in the gamma-aminobutyric acid (GABA)-ergic system may contribute to onset. Recently, antidepressants (e.g., brexanolone, zuranolone) targeting GABA-A receptor were introduced. The zona incerta (ZI), an inhibitory subthalamic region mainly composed of GABAergic neurons, has been implicated emotional regulation. Deep brain stimulation ZI humans affects anxiety and depression symptoms,...
Objective To compare the medial-to-lateral approach with lateral-to-medial in laparoscopic right hemi-colectomy for colon cancer. Methods A prospective randomized controlled trial was performed Fujian provincial tumor hospital between January 2007 and July 2009. Forty-eight cases eolon cancer were randomly divided into two groups:medial-to- lateral group(group M) hemicolectomy L). Primary outcome(operative time) secondary outcomes (estimated blood loss, intra-operative complication,...
Abstract Background In rectal cancer surgery, recent studies have found associations between clinical factors, especially pelvic parameters, and surgical difficulty; however, their findings are inconsistent because the use different criteria. This study aimed to evaluate common factors that influence operative time for laparoscopic anterior resection of low middle cancer. Methods Patients who underwent radical from January 2018 December 2020 were retrospectively analyzed classified according...
The technical safety and efficacy of single-incision plus one-port laparoscopic surgery (SILS+1) for distal gastric cancer remain unclear. This study was performed to compare the short-term outcomes patients with undergoing SILS+1 versus conventional (CLS).This randomized controlled trial involved clinical stage cT1b-3N0-2M0 cancer. were CLS group or group. surgical pathologic outcomes, postoperative mortality, pain intensity compared between two groups.From January 2019 April 2021, 117...
The efficacy of reduced-port laparoscopic surgery (RLS) for total gastrectomy remains unclear. This study focused on evaluating the short-term outcomes RLS compared with conventional (CLS) gastrectomy.One hundred and ten patients who underwent completed gastric cancer between September 2018 June 2022 were retrospectively collected classified into two groups (65 CLS 45 RLS) according to different operation approach. Twenty-four cases single-incision plus ports (SILS + 2) twenty-one one port...
Preoperative serum level of carcinoembryonic antigen (pCEA) is generally recognized as a prognostic factor for colorectal cancer (CRC), but the stage-specific role pCEA in remains unclear.We investigated significance levels different tumor stages nonmetastatic CRC patients.Six hundred and fifteen patients at stage I-III were retrospectively analyzed. All them received curative resection. The X-tile program was used to generate cutoff values all two subpopulations (lymph node-positive or...
Infra-pyloric artery (IPA) is an important anatomical landmark in treatment of gastric cancer and the key vessel for pylorus-preserving gastrectomy subgroup infra-pyloric lymph nodes. However, its variation not thoroughly understood. Our study aimed to clarify origination IPA.We did this prospective, multicenter, open-label, observational at surgery departments 34 hospitals China. Gastric patients aged 18 years or older scheduled undergo elective total distal were assigned. During surgery,...
TPS415 Background: The CLAEG study (ChiCTR1900026131) is a prospective, real-world data evaluation of the clinical outcomes patients with AEG following radical resection to investigate lymph node (LN) metastasis patterns and refine treatment strategies. Methods: Data from 44 hospitals in China were collected using designed CRF, comprising baseline, surgical details, pathology results recovery progress January 1,2020. cut-off was August 31, 2023. ongoing. Results: A total 1322 enrolled, only...
This study aimed to compare the efficacy of Single-Port plus One Port Laparoscopy (SILS + 1) with Conventional Multi-Port Laparoscopic Surgery (CLS) and investigate risk factors associated postoperative complications in patients sigmoid colon cancer undergoing laparoscopy. Male treated at our hospital were selected evenly distributed into CLS SILS 1 groups further categorized complication non-complication based on their status within 30 days post-surgery. Compared group, SILS+ group had...
The aim of the present study was to evaluate a nomogram model for predicting 5-year overall survival (OS) in lymph node-metastatic colorectal cancer (CRC) patients by combining inflammation markers with some traditional prognostic factors.A total 399 stage III (pTXN1-3M0) CRC operated from January 2007 December 2012 were enrolled this retrospective study. All underwent D2 lymphadenectomy hospital. A based on integration factors and NLR (neutrophil-to-lymphocyte ratio) PLR...
Background: B-II reconstruction is a mature way in radical operation of gastric cancer. It can confirm the negative margin advanced And it makes digestive juices flow more freely and prevents delayed emptying with Braun’s anastomosis. Methods: We choose 59-year-old man moderately differentiated adenocarcinoma antrum who was diagnosed by gastroscopy histological test conform to treatment standard totally laparoscopic distal gastrectomy (TLDG) D2 lymph node dissection Results: The total length...
Total laparoscopic-assisted radical gastrectomy and the jejunal Roux-en-Y anastomosis were performed to treat cancer of upper gastric body fundic region. In case open during total gastrectomy, an incision 6-8 cm would be required due need for placing stapler anvil. If using procedure, however, could reduced as small 4-5 without increasing length operation intraoperative bleeding that favors postoperative recovery.