A5102021341- Colorectal Cancer Surgical Treatments
- Colorectal and Anal Carcinomas
- Gastric Cancer Management and Outcomes
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Cancer-related gene regulation
- Anorectal Disease Treatments and Outcomes
- Microtubule and mitosis dynamics
- Extracellular vesicles in disease
- Ubiquitin and proteasome pathways
- Neuropeptides and Animal Physiology
- Heat shock proteins research
- Vascular Procedures and Complications
- Colorectal Cancer Screening and Detection
- Iron Metabolism and Disorders
- Cancer Research and Treatments
- Colorectal Cancer Treatments and Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Wnt/β-catenin signaling in development and cancer
- Autophagy in Disease and Therapy
- Asthma and respiratory diseases
- Cellular transport and secretion
- Case Reports on Hematomas
- Aortic aneurysm repair treatments
- Developmental Biology and Gene Regulation
China Medical University
2015-2025
Huazhong University of Science and Technology
2016-2024
Jiangsu University
2023-2024
Union Hospital
2016-2024
China XD Group (China)
2023
Tongji Hospital
2022
Second Xiangya Hospital of Central South University
2016
Central South University
2016
Cancer cell-derived exosomes have been actively released into the tumor microenvironment with pleiotropic roles in growth and metastasis, including angiogenesis immune modulation. However, functions underlying mechanisms of shed by colorectal cancer (CRC) cells under hypoxic conditions remain unknown. Here we found that derived from CRC promoted proliferation migration endothelial cells. Suppression exosome secretion through RAB27a knockdown inhibited exosomal-induced Furthermore, discovered...
The efficacy of laparoscopic vs open surgery for patients with low rectal cancer has not been established.
Hypoxia is the most common characteristic of solid tumours driving cancer metastasis. Cancer cells release exosomes with various functions into tumour microenvironment during progression. However, roles and associated mechanisms hypoxic colorectal (CRC) cell-derived remain poorly understood. Here, we found that secreted by CRC promoted migration invasion abilities normoxic cells. Inhibition exosome secretion GW4869 reduced exosome-mediated Furthermore, these contained Wnt4 depending on...
Colorectal cancer (CRC) is a common malignancy with high mortality. However, the roles of miR-425-5p and its underlying mechanism in CRC remain unknown. Here, RT-qPCR confirmed that expression was increased by mimic SW480 cells decreased inhibitor LOVO cells. CCK-8, flow cytometry, wound healing transwell assays revealed promoted cell viability, cycle entry, migration invasion CRC. Besides, overexpression induced epithelial–mesenchymal transition (EMT) upregulation Fibronectin, N-cadherin,...
Published studies reported that loss of function the p15(INK4B) gene is caused by hypermethylation; however, whether or not inactivation associated with incidence and clinical significance multiple myeloma (MM) remains unclear. In this study, we performed a meta-analysis to quantitatively determine effects p15 hypermethylation on MM. The related research articles in English Chinese languages were evaluated. data extracted assessed independently. pooled analyzed odds ratios calculated...
Addressing the demand for efficient biological degradation of straw, this study employed rational design coupled with structural biology and enzyme engineering techniques to enhance catalytic activity cellobiose dehydrogenase (
RING finger protein 112 (RNF112) exerts a key role in human tumors. However, its biological function colorectal cancer (CRC) has not been discussed. We aimed to explore the and molecular mechanism of RNF112 CRC. In this study, expression was notably decreased CRC tissues cells. Clinical analysis revealed significant association between low tumor size, N classification TNM stage. vitro experiments demonstrated that overexpression repressed cell viability, promoted cycle arrest apoptosis,...
Rab25 was reported to be associated with several human cancers and malignant biological behavior of cancer cells. The goal the present study determine its expression pattern function in hepatocellular carcinoma (HCC). We examined protein 92 cases HCC tissues 3 cell lines. results showed that upregulated cells compared normal liver line. overexpression correlated advanced tumor stage nodal metastasis. small interfering RNA (siRNA) employed Bel7402 SK-Hep-1 Cell Counting Kit-8 (CCK-8) assay...
Rab5a was reported to be overexpressed in human malignancy and associated with the malignant phenotype. To data, its expression pattern biological function hepatocellular carcinoma (HCC) have not been studied. We analyzed protein 98 cases of HCC tissues four cell lines. found that upregulated overexpression correlated TNM stage nodal metastasis (p < 0.05). confirm lines, siRNA employed SK-Hep-1 line plasmid transfection performed Huh7 line. CCK-8 assay showed depletion blocked growth rate...
Background: Researchers have long been interested in the potential relationship between osteoarthritis (OA), falls, and fractures; however, evidence supporting this has conflicting. This study aimed to investigate association future fracture events. Materials Methods: was designed as a prospective cohort study. We recruited total of 440,476 individuals from UK Biobank impact OA on incidence fracture. Among population, there were 54,581 participants diagnosed with OA. Cox proportional hazard...
Synaptojanin 2 Binding Protein (SYNJ2BP) is essential to cell proliferation. Previous studies show that SYNJ2BP participates in sprouting angiogenesis, which plays an important part several abnormal conditions including cancer. However, the activity of hepatocellular carcinoma (HCC) has not been elucidated yet. Firstly, real-time PCR and western blotting (WB) were adopted evaluate expressions HCC tissues lines. Secondly, we did follow-up prognostic study explore association expression...
Oxytocin (OXT) and its receptor (OXTR) are present in the gastrointestinal system involved tumorigenesis. However, effect of OXTR signaling on development colorectal cancer (CRC) underlying mechanisms remain unexplored. To address these issues, we first examined expressions OXT, several cancer-associated proteins using colon "tissue chips" from a spectrum malignant progression colon, which included normal tissue, chronic colitis, adenoma, adenocarcinoma (CAC). The results showed that OXT...
For laparoscopic low anterior resection of the rectum, a small additional incision is needed to extract specimen. We describe an adjustment technique, which inserted anvil and extracted specimen through transanal pathway.Between July 2010 2012, 23 patients underwent rectal surgery with insertion prolapsing extraction. All perioperative data short-term outcomes were recorded in database.The mean patient age was 61.3 years (range 47-68 years). Of patients, 17 for carcinoma 6 had tubulovillous...
<title>Abstract</title> Background Establishing accurate spirometry reference values for Chinese children is essential diagnosing and managing respiratory conditions. This study aims to develop spirometric healthy children. Methods A cross-sectional involving aged 4 18 years from 33 research centers across 24 regions in China was conducted. Physical growth indices were measured tests New prediction equations developed using multiple linear regression models with age, height, weight as...
To investigate the value of exercise challenge testing (ECT) in diagnosis cough variant asthma (CVA) children.
Proliferating ability of transitional mucosa adjacent to rectal carcinoma and its clinical significance in sphincter preserving operations