A5100340694- Pain Mechanisms and Treatments
- NF-κB Signaling Pathways
- Neuropeptides and Animal Physiology
- Functional Brain Connectivity Studies
- Ion Channels and Receptors
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Nerve injury and regeneration
- Mental Health Research Topics
- Immune Response and Inflammation
- Glaucoma and retinal disorders
- Connexins and lens biology
- Pharmacological Effects of Natural Compounds
- Cancer, Hypoxia, and Metabolism
- Treatment of Major Depression
- Neurotransmitter Receptor Influence on Behavior
- Advanced Neuroimaging Techniques and Applications
- Reproductive tract infections research
- FOXO transcription factor regulation
- Cancer Treatment and Pharmacology
- Diet, Metabolism, and Disease
- Inflammasome and immune disorders
- Circular RNAs in diseases
- Gastric Cancer Management and Outcomes
- Histone Deacetylase Inhibitors Research
West China Hospital of Sichuan University
2020-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2025
Guizhou Provincial People's Hospital
2025
Sichuan University
2020-2025
South China Agricultural University
2025
The Affiliated Yongchuan Hospital of Chongqing Medical University
2025
Chongqing Medical University
2025
Zhongshan Hospital
2015-2024
Fudan University
2012-2024
Affiliated Hospital of Southwest Medical University
2024
Abstract The pentose phosphate pathway (PPP) plays a critical role in macromolecule biosynthesis and maintaining cellular redox homoeostasis rapidly proliferating cells. Upregulation of the PPP has been shown several types cancer. However, how is regulated to confer selective growth advantage on cancer cells not well understood. Here we show that glucose-6-phosphate dehydrogenase (G6PD), rate-limiting enzyme PPP, dynamically modified with an O-linked β-N-acetylglucosamine sugar response...
The aim of the present study was to investigate mechanisms underlying desensitization 5-HT 1A receptors in dorsal raphe and hypothalamus serotonin (5-HT) transporter knock-out mice (5-HTT −/−). density reduced both male female 5-HTT −/− mice. This reduction more extensive than 8-OH-DPAT-induced hypothermia absent markedly attenuated +/− also decreased significantly several nuclei hypothalamus, amygdala, septum receptor mRNA region, but not or hippocampus, G-protein coupling levels most brain...
Abstract Background Glaucoma, the leading cause of irreversible blindness worldwide, is a type retinal disease characterized by selective death ganglion cells (RGCs). However, pathogenesis glaucoma has not been fully elucidated. Transient receptor potential vanilloid 4 (TRPV4) pressure-sensitive and calcium-permeable cation channel. TRPV4 widely distributed in retina its sustained activation leads to RGC death; indicating that may be possible target for treatment. Here, we investigated...
Abstract The synergistic effect of neoadjuvant immunotherapy and chemoradiotherapy in gastric adenocarcinoma is unclear. This phase II trial (NCT03631615) investigated this combination locally advanced stomach or gastroesophageal junction. Thirty-six patients received capecitabine 850 mg/m 2 twice daily simultaneous radiotherapy for 5 weeks, sandwiched by a 21-day cycle oxaliplatin 130 (day 1) plus 1000 (days 1–14), respectively, followed surgery. Camrelizumab 200 mg was given cycles since...
Parkinson's disease (PD) is a neurodegenerative condition characterized by chronic inflammation. Nuclear factor<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>κ</mml:mi></mml:math>B (NF-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>κ</mml:mi></mml:math>B) family of inducible transcription factors that are expressed in wide variety cells and tissues, including microglia, astrocytes, neurons, the classical NF-<mml:math pathway plays key role activation...
Parkinson9s disease (PD) is a progressive neurological disorder characterized by selective loss of dopamine (DA) neurons in the substantia nigra (SN). Although current therapy can control symptoms this disorder, there no effective available to halt its progression. Recently, neuroinflammation has been recognized as an important contributor pathogenesis PD, and nuclear factor-κB (NF-κB) plays key role regulating neuroinflammation. Hence, modulation NF-κB pathway may have therapeutic potential...
Abstract Curcumin has been shown to possess strong anti-inflammatory activity in many diseases. It demonstrated that the janus kinase 2 (JAK2)-signal transducer and activator of transcription 3 (STAT3) cascade NAcht leucine-rich-repeat protein 1 (NALP1) inflammasome are important for synthesis Pro-Interleukin (IL)-1β processing inactive its mature form, which plays an active role pathogenesis neuropathic pain. The present study showed repeated intraperitoneal injection curcumin ameliorated...
Background: Neuropathic pain is detrimental to human health; however, its pathogenesis still remains largely unknown. Overexpression of pain-associated genes and increased nociceptive somato-sensitivity are well observed in neuropathic pain. The importance epigenetic mechanisms regulating the expression pro- or anti-nociceptive has been revealed by studies recently, we hypothesize that transcriptional coactivator histone acetyltransferase E1A binding protein p300 (p300), as a part gene...
Poly-ubiquitination-mediated RUNX2 degradation is an important cause of age- and inflammation-related bone loss. NEDD4 family E3 ubiquitin protein ligases are thought to be the major regulators poly-ubiquitination. However, we observed a mono-ubiquitination that was catalyzed by WWP2, member ligases. WWP2 has been reported catalyze Goosecoid in chondrocytes, facilitating craniofacial skeleton development. In this study, found osteogenic differentiation mesenchymal stem cells promoted...
Forkhead box O3A (FOXO3a) is an important transcription factor involved in various human cancers. However, the role of FOXO3a regulating invasion and metastasis gastric cancer cells has not been clarified. Here, we report that overexpression promoted migration by upregulating cathepsin L. knockdown suppressed also downregulated L expression cells. Silencing these overexpression-induced cell invasion. Mechanistic studies revealed increased promoter activation, repressed E-cadherin expression,...
Significance The clearance of apoptotic cells is critical for maintaining tissue homeostasis, and myeloid C-type lectin receptors (CLRs) may be prominently involved in the dying their debris. Here, we report that CLR member LSECtin expressed on macrophages, which are engaged corpse clearance. This engulfment progress by macrophages through intestinal healing. Loss promotes dextran sulfate sodium-induced colitis due to unrepaired epithelium. These results indicate can direct regeneration....
Abstract Trigeminal neuralgia (TN) is debilitating and usually accompanied by mood disorders. The lateral habenula (LHb) considered to be involved in the modulation of pain disorders, present study aimed determine if how LHb participates development anxiety TN. To address this issue, a mouse model partial transection infraorbital nerve (pT-ION) was established. pT-ION induced stable long-lasting primary secondary orofacial allodynia anxiety-like behaviors that correlated with increased...
Background The herbs Baidoukou (the fruit of Amomum compactum Sol. ex Maton), Baijusheng Lactuca sativa L.), and Biba ( Piper longum L.) make up the traditional Mongolian medicine known as Sugemule-3 decoction. Purpose: Heart failure (HF) is severely impacted; however, pharmacological mechanism behind it yet unclear. This investigation looked at ethanol extract’s therapeutic for isoproterenol-induced HF in rats. Methods To create a model, isoproterenol was administered to Wistar Following...
Porcine reproductive and respiratory syndrome virus (PRRSV) is a persistent pathogen that causes significant economic losses to the global swine industry. Commercial vaccines provide only partial protection, no effective therapeutic treatments are currently available. In this study, we demonstrate hesperetin (Hst), flavonoid glycoside derived from orange tangerine peels, inhibits PRRSV replication in dose-dependent manner Marc-145 PAMs cells. Transcriptome analysis further reveals anti-PRRSV...
ABSTRACT Major depressive disorder (MDD) is characterized by intercorrelated clinical symptoms and cognitive deficits, whose neural mechanisms in relation to these disturbances remain unclear. To elucidate this, we applied the relatively new approach of Network Control Theory (NCT), which considers how network topology informs brain dynamics based on white matter connectivity data. We used NCT parameter average controllability (AC) assess potential control that nodes have brain‐state...