A5082179050- Neuropeptides and Animal Physiology
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Neuroscience and Neuropharmacology Research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Neuroendocrine regulation and behavior
- Phytoestrogen effects and research
- Memory and Neural Mechanisms
- Autism Spectrum Disorder Research
- Genetics and Neurodevelopmental Disorders
- Stress Responses and Cortisol
- Ion channel regulation and function
- Cholinesterase and Neurodegenerative Diseases
- Congenital heart defects research
- Effects and risks of endocrine disrupting chemicals
- Biochemical Analysis and Sensing Techniques
- Estrogen and related hormone effects
- Birth, Development, and Health
- Cancer, Stress, Anesthesia, and Immune Response
- Attention Deficit Hyperactivity Disorder
- Nerve injury and regeneration
- Toxin Mechanisms and Immunotoxins
- GABA and Rice Research
- Biochemical effects in animals
- Nutrition, Genetics, and Disease
Drake University
2006-2021
National Institutes of Health
2002-2006
National Institute of Mental Health
2001-2004
Rush University Medical Center
2001
University of Washington
2001
United States Department of Veterans Affairs
2001
Vanderbilt University
1996-2001
Nashville VA Medical Center
1996-1999
Galanin is a neuropeptide with multiple inhibitory actions on neurotransmission and memory. In Alzheimer's disease (AD), increased galanin-containing fibers hyperinnervate cholinergic neurons within the basal forebrain in association decline cognition. We generated transgenic mice (GAL-tg) that overexpress galanin under control of dopamine β-hydroxylase promoter to study neurochemical behavioral sequelae mouse model overexpression AD. Overexpression was associated reduction number...
Social transmission of food preference (STFP) is a test olfactory memory that can be used in mice. Confounds STFP lead to misinterpretation an deficit as impairment include changes social interaction and olfaction. The issue was addressed by evaluating observer-centric demonstrator-centric method for scoring the phase applied line STFP-impaired, galanin-overexpressing transgenic (GAL-tg). GAL-tg mice were impaired without deficits interaction. In tests ability, unimpaired on buried-food...
Abstract The neuropeptide galanin induces performance deficits in a wide range of cognitive tasks rodents. Three G‐protein‐coupled receptor subtypes, designated GAL‐R1, GAL‐R2 and GAL‐R3, have been cloned. present study examined the role GAL‐R1 cognition by testing mice with null mutation Galr1 on several different types learning memory tasks. Assessments general health, neurological reflexes, sensory abilities motor functions were conducted as control measures. Mutant unimpaired social...
Abstract Glutamate carboxypeptidase II (GCPII, EC 3.14.17.21) is a membrane‐bound enzyme found on the extracellular face ofglia. The gene for this designated FOLH1 in humans and Folh1 mice. This has been proposed to be responsible inactivation of neurotransmitter N ‐acetylaspartylglutamate (NAAG) following synaptic release. Mice harboring disruption GCPII/ were generated by inserting into genome targeting cassette which intron–exon boundary sequences exons 1 2 removed stop codons inserted 2....
Galanin inhibits the release of several neurotransmitters and produces performance deficits in a variety spatial aversive learning memory tasks. The experiments this study investigated role galanin has emotional using standard delay cued contextual fear conditioning task. Rats were administered into lateral ventricles before training, scored for freezing behavior same context novel with without an auditory cue (CS) that had been paired previously stimulus (US). Galanin-overexpressing...
The social transmission of food preference (STFP) is an ethologically relevant test olfactory memory that can be used in mice. In this test, "observer" mice interact with a "demonstrator" mouse has recently eaten novel food. When observer are presented choice between the by demonstrator and some other food, prefer demonstrator. This phenomenon depends on detecting cues breath during their interaction. subsequent serves as measure for those cues. unit describes method performing STFP mutant...
Degeneration of the cholinergic basal forebrain (CBF) and changes in cortical neuropeptide levels have been reported Alzheimer's disease. In present study, we sought to determine if a selective lesion nucleus basalis magnocellularis (Nbm) could affect number distribution Y (NPY) somatostatin (SS) immunoreactive neurons frontoparietal occipital cortices rats. Brain sections were evaluated at survival times 1, 2, 4, 8, 12, 24, 48, 78 100 weeks after intraventricular injection 192-saporin, an...