A5046571498- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Peptidase Inhibition and Analysis
- Cancer Mechanisms and Therapy
- Cancer therapeutics and mechanisms
- Cervical Cancer and HPV Research
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- RNA modifications and cancer
- Thyroid Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- AI in cancer detection
- Salivary Gland Tumors Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Gastric Cancer Management and Outcomes
- Global Cancer Incidence and Screening
- Cytokine Signaling Pathways and Interactions
- Pancreatic and Hepatic Oncology Research
- Ovarian cancer diagnosis and treatment
- Metastasis and carcinoma case studies
- Head and Neck Cancer Studies
- Congenital Diaphragmatic Hernia Studies
- Epigenetics and DNA Methylation
- Phytochemistry and Bioactivity Studies
Zhejiang Cancer Hospital
2016-2025
The Fourth People's Hospital of Zibo City
2025
Chinese Academy of Sciences
2021-2024
Shanxi Medical University
2023
University of Chinese Academy of Sciences
2020-2023
Zhejiang Provincial People's Hospital
2023
Zhejiang Chinese Medical University
2020
Zhejiang University
2020
Hangzhou Cancer Hospital
2016-2018
Jiangsu University
2017
Abstract The pentose phosphate pathway (PPP) plays a critical role in macromolecule biosynthesis and maintaining cellular redox homoeostasis rapidly proliferating cells. Upregulation of the PPP has been shown several types cancer. However, how is regulated to confer selective growth advantage on cancer cells not well understood. Here we show that glucose-6-phosphate dehydrogenase (G6PD), rate-limiting enzyme PPP, dynamically modified with an O-linked β-N-acetylglucosamine sugar response...
Here, we have investigated treatment resistance mechanisms in small cell lung cancer (SCLC) by focusing on comparing the genotype and phenotype tumor samples of treatment-resistant treatment-sensitive SCLC.We conducted whole-exome sequencing paired at diagnosis relapse from 11 patients with limited-stage (LS)-SCLC targeted 1,021 cancer-related genes cell-free DNA baseline relapsed 9 additional LS-SCLC. Furthermore, performed label-free mass spectrometry-based proteomics 28 chemo-resistant 23...
Abstract Accurate detection of circulating tumor cells (CTCs) in blood and non-blood body fluids enables generation deterministic cancer diagnosis represent a less invasive safer liquid biopsy approach. Although genomic alternations have been widely used DNA (ctDNA) analysis, studies on cell-based profiling for CTC are rare due to major technical limitations single-cell whole genome sequencing (WGS) including low throughput, accuracy high cost. We report low-pass WGS-based protocol...
According to the latest World Health Organization (WHO) classification in 2015, invasive mucinous adenocarcinoma (IMA) is defined as a new pathological subtype of lung (LUAD). However, whether this rare pathology has any difference prognosis than conventional LUAD debatable. Our study attempted compare clinical characteristics and IMA vs. noninvasive adenocarcinomas (NMA).A total 1,857 patients with who underwent radical resection were screened from 2010 2015 at Zhejiang Cancer Hospital....
Cytology-based triaging is commonly used to manage the care of women with positive human papillomavirus (HPV) results, but it suffers from subjectivity and a lack sensitivity reproducibility. The diagnostic performance an artificial intelligence-enabled liquid-based cytology (AI-LBC) triage approach remains unclear. Here, we compared clinical AI-LBC, cytologists HPV16/18 genotyping at HPV-positive women.HPV-positive were triaged using genotyping. Histologically confirmed cervical...
Zolbetuximab (IMAB362) is under investigation for treating advanced gastrointestinal tumors because it targets Claudin18.2 (CLDN18.2). CLDN18.2 a promising molecule along with the presence of human epidermal growth factor receptor 2 in gastric cancer. This study evaluated cell block (CB) preparations serous cavity effusions feasibility protein expression and compared results those biopsy or resection specimens. The association effusion samples clinicopathological features were also...
Deep learning (DL) enabled liquid-based cytology has potential for cervical cancer screening or triage. Here, we develop a DL model using whole slides from 17,397 women and test it on 10,826 additional cases through three-stage process. The achieves robust performance across nine hospitals. In multi-reader, multi-case study, outperforms cytopathologists' sensitivity by 9%. Reading time significantly decreases with assistance (218s vs 30s; p < 0.0001). community-based organized screening, the...
ABSTRACT Background and Aims Tegoprazan, a new class of drugs, is potassium‐competitive acid blocker (P‐CAB) that inhibits gastric H+/K+‐ATPase through different mechanism than proton pump inhibitor. Tetracycline also has anti‐ Helicobacter pylori properties. However, only few randomized controlled trials (RCTs) have investigated the efficacy tegoprazan tetracycline‐containing quadruple therapy (TTQT) for treating H. infections, which this RCT explored. Methods This multicenter included...
Malignant pleural effusion (MPE) represents advanced malignant disease with poor prognosis. To date, cytology remains the best test to diagnose MPE but suffers from limited diagnostic sensitivity and high variation. We report a hexokinase 2-based method (HK2-seq) as novel for multicancer diagnosis.HK2-seq employed HK2 new metabolic function-associated marker detect disseminated tumor cells engaging increased glycolysis in many cancer types. Single-cell sequencing was used confirm malignancy...
HER2-positive gastric cancer is a distinct tumor subtype, accounting for ~10% of cases. It characterized by HER2 overexpression and responds well to HER2-targeting therapies. Recently, the addition immune checkpoint inhibitors therapies produced satisfactory outcomes in these patients. In present study, we used gene expression profiles patient surgical sections analyze microenvironment characteristics tumors with high expression. Several differentially enriched pathways were identified...
Lung adenosquamous carcinoma (ASC) is a rare malignant tumor with an adenocarcinoma and squamous cell component associated lower 5-year survival rate than lung adenocarcinoma. Surgical specimen histology revealed the inadequacy of conventional transbronchial needle aspiration samples in diagnosis ASC. Most ASC patients are not suitable to receive surgery, it difficult diagnose This study explore possibility using serum carcinoembryonic antigen (CEA) (SCC) as supplementary diagnostic test for...
To investigate the value of immunocytochemical (ICC) staining for human papillomavirus (HPV) E7 protein (E7-ICC staining) as a new-generation immunological method in cytological diagnosis cervical lesions.The exfoliated cell samples 690 women were subjected to liquid-based cytology test (LCT), high-risk HPV (HR-HPV) test, E7-ICC staining, and biopsy pathological diagnosis.E7-ICC preliminary screening scheme precancerous lesions was comparable HR-HPV sensitivity LCT specificity. advantageous...
Small cell lung cancer (SCLC) is sensitive to first-line chemotherapy and radiotherapy, but frequently recurs. Temozolomide a chemotherapeutic drug suitable for the treatment of relapsed SCLC, particularly when brain metastases are present. The response SCLC temozolomide may be associated with methylation status O6-methyl-guanine-DNA methyltransferase (MGMT). Isocitrate dehydrogenase (IDH) mutation an independent prognostic factor good outcome in gliomas appears significant marker positive...
Objective: The aim was to evaluate the effectiveness of computed tomography (CT)-guided fine-needle aspiration biopsy (FNAB) from Mandibular notch and under zygomatic arch for pathological diagnosis recurrence nasopharyngeal carcinoma (NPC) after radiotherapy (RT). Materials Methods: Between October 2007 December 2013, 48 patients with suspected recurrent NPC underwent CT-guided FNAB. A modified coaxial technique used in all cases, multiple samples were obtained histological studies....
The prognosis of small-cell lung cancer (SCLC) is poor despite reports suggesting modest improvement in survival. To date, chemotherapy remains the cornerstone treatment for SCLC patients, and many studies have focused on identifying molecular characteristics SCLC, which serve as basis precision treatments that improve SCLC. For instance, therapeutic effect temozolomide, recommended patients with relapsed linked to 1p/19q codeletion anaplastic oligodendroglial tumors. A subpopulation may...
Abstract Introduction: Although small-cell lung cancer (SCLC) is sensitive to first-line radiation and chemotherapy, nearly all patients recur often with treatment-resistant disease. Therefore, delineating subclonal architecture molecular evolution of SCLC after treatment by comparing genomic profiles recurrent paired treatment-naïve tumors may provide new insights into mechanisms underlying recurrence susceptibility further treatment. Methods: Treatment-naïve tumor samples from 9...