A5101403441- MicroRNA in disease regulation
- Chemical Synthesis and Analysis
- Advanced biosensing and bioanalysis techniques
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Phytochemical Studies and Bioactivities
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Amino Acid Enzymes and Metabolism
- Traditional Chinese Medicine Analysis
- Natural product bioactivities and synthesis
- RNA modifications and cancer
- Plant Micronutrient Interactions and Effects
- RNA Interference and Gene Delivery
- Heparin-Induced Thrombocytopenia and Thrombosis
- Helicobacter pylori-related gastroenterology studies
- Genetic factors in colorectal cancer
- Genomic variations and chromosomal abnormalities
- Hydrogels: synthesis, properties, applications
- Covalent Organic Framework Applications
- Intramuscular injections and effects
- Melanoma and MAPK Pathways
- Building Energy and Comfort Optimization
- Phosphodiesterase function and regulation
Qilu Hospital of Shandong University
2025
Zaozhuang Municipal Hospital
2025
Sinopec (China)
2024
Nanjing University of Chinese Medicine
2019-2022
Shenyang Agricultural University
2021
Nantong University
2007-2020
Jilin Academy of Traditional Chinese Medicine
2019-2020
Yale University
2020
Kaiser Permanente Santa Clara Medical Center
2020
Huazhong University of Science and Technology
2020
A colorimetric immunosensor for IAV based on AuNPs modified with mAb is developed. This assay depends an ordered structure covering the virus surface and can be applied to any viral pathogen by incorporating appropriate pathogen-specific antibody, giving proposed method a broad prospect in clinical diagnosis applications.
The c-Jun N-terminal kinases (JNK-1, -2, and -3) are members of the mitogen activated protein (MAP) kinase family enzymes. They in response to certain cytokines, as well by cellular stresses including chemotoxins, peroxides, irradiation. have been implicated pathology a variety different diseases with an inflammatory component asthma, stroke, Alzheimer's disease, type 2 diabetes mellitus. In this work, high-throughput screening identified JNK inhibitor excellent selectivity profile. Using...
Stearoyl-CoA desaturase 1 (SCD1) catalyzes the committed step in biosynthesis of monounsaturated fatty acids from saturated, long-chain acids. Studies with SCD1 knockout mice have established that these animals are lean and protected leptin deficiency-induced diet-induced obesity, greater whole body insulin sensitivity than wild-type animals. In this work, we discovered a series potent, selective, orally bioavailable inhibitors based on known pyridazine carboxamide template. The...
Surgical operations are the preferred treatment for gastric perforation (GP) but incur postoperative complications such as gastrointestinal adhesions and bacterial infections, leading to inefficient wound healing serious that may even threaten life of patient. Developing hydrogel dressings capable adapting environment (acid) decreasing visceral infections after GP is crucial. In this article, we developed an injectable, self-healing using cation–π interactions between protonated amines...
ABSTRACT Background and Aims Tegoprazan, a new class of drugs, is potassium‐competitive acid blocker (P‐CAB) that inhibits gastric H+/K+‐ATPase through different mechanism than proton pump inhibitor. Tetracycline also has anti‐ Helicobacter pylori properties. However, only few randomized controlled trials (RCTs) have investigated the efficacy tegoprazan tetracycline‐containing quadruple therapy (TTQT) for treating H. infections, which this RCT explored. Methods This multicenter included...
Stroke is one of the leading causes death and long-term disability worldwide. Gross saponins Tribulus terrestris fruit (GSTTF) has been used for neuroprotective therapy on convalescents ischemic stroke. But related therapeutic mechanisms have not yet well investigated. This study aimed to investigate protective effects GSTTF stroke using metabolomics coupled with network pharmacology analysis. The rat urine sample was collected profiled by an LC-MS-based approach. pathway analysis performed...
Circular RNAs (circRNAs) are a new class of RNA molecules whose function is largely unknown. There growing evidence that circRNAs play an important regulatory role in the progression variety human cancers. However, exact roles and mechanisms gastric cancer not clear. In this study, we aimed to elucidate mechanism hsa_circ_0005556.Real-time quantitative polymerase chain reaction was used detect expression hsa_circ_0005556, miR-4270, matrix metalloproteinase-19 (MMP19) tissues cell lines. The...
The development of glycine transporter 1 (GlyT1) inhibitors may offer putative treatments for schizophrenia and other disorders associated with hypofunction the glutaminergic N-methyl-d-aspartate (NMDA) receptor. Herein, we describe synthesis biological evaluation a series 3,4-disubstituted pyrrolidine sulfonamides as competitive GlyT1 that arose from de novo scaffold design. Relationship chemical structure to drug-drug interaction (DDI) bioactivation was mechanistically investigated. Murine...
A variety of microRNAs (miRNAs) are involved in the occurrence and development hepatocellular carcinoma (HCC). However, role miR-10a-5p progression HCC remains unclear. Therefore, purpose this study was to determine possible molecular mechanism. expression tissues plasma from patients detected by quantitative real-time polymerase chain reaction. Migratory changes cells were after overexpression miR-10a-5p. Epithelial-mesenchymal transition (EMT)-related proteins Western blot. Finally,...
Abstract Background The EGFR‐vIII mutation is the most common malignant event in GBM. Epigenetic reprogramming EGFR‐activated GBM has recently been suggested to downregulate expression of tumour suppressor genes. Histone acetylation important for chromatin structure and function. However, role biological function H2AZK4/7AC tumours have not yet clarified. Results In our study, we found that negatively regulated though PI3K/AKT‐HDAC2 axis. Because HDAC1 HDAC2 are highly homologous enzymes...
Phosphorus (P) is an essential element for the growth and development of plants. Soybean (Glycine max) important food crop that grown worldwide. yield significantly affected by P deficiency in soil. To investigate molecular factors determine response tolerance at low-P soybean, we conducted a comparative proteomics study genotype with (Liaodou 13, L13) sensitivity (Tiefeng 3, T3) paper culture experiment three treatments, i.e. P-free (0 mmol·L-1), (0.05 mmol·L-1) normal-P (0.5 mmol·L-1). A...
Abstract An increasing amount of evidence shows that circular RNAs (circRNAs) have critical effects on cancer progression and development; however, the biological function potential molecular mechanism circRNAs in hepatocellular carcinoma (HCC) are still unclear. CircRNA sequencing was used to identify differentially expressed between HCC tissue adjacent normal tissue. We found circ_0001459 expression significantly elevated cell lines. Furthermore, vitro vivo functional experiments were...
The glycine transporter 1 (GlyT1) has emerged as a key novel target for the treatment of schizophrenia. Herein, we report synthesis and biological evaluation aminotetralines aminochromanes classes competitive GlyT1 inhibitors. Starting from high-throughput screening hit, structure–activity relationship studies led first to discovery displaying high potency selectivity, with favorable pharmacokinetic properties. Systematic investigations various parameters (e.g., topological polar surface...
Carbonizing by stir-frying (CSF) is the most common technology in botanical folk medicines to enhance convergence, hemostasis, and antidiarrheal effects. Sanguisorbae Radix (SR), a well-known herbal medicine China, has extensive therapeutic functions, while charred SR known as an additional product obtained from after CSF. In this study, mass spectrometry was used investigate effect of charring on tannins transformation SR. The findings showed that content level decreased significantly...
The reprocessing stability and recyclability of bio-based thermosetting materials have positive environmental economic values. In this work, two types lignocellulosic polyimide vitrimers were developed from lignin-derived aldehyde monomers a cellulose-derived diamine monomer based on dynamic covalent adaptive network. Both demonstrated high fracture strengths up to 67.5 40.2 MPa, the had no obvious dissolution weight change after soaking in ten common solvents for 30 days. Similar other...
Background: Esophageal squamous cell carcinoma (ESCC) is one of the most lethal cancer due to insufficient actionable molecules. Radiotherapy (RT) plays a vital role in treatment ESCC, while radioresistance significant challenge RT and results locoregional distant failure. Methods: Radioresistance complex involving confounding factors, its genetic mechanism challenging study. Postoperative recurrence after more likely be causes than unoperated patients. Therefore, two independent cohorts...
Label-free electrochemical detection of DNA methyltransferase activity<italic>via</italic>DNA tetrahedron-structured probe.