A5102777151- Cancer Cells and Metastasis
- IL-33, ST2, and ILC Pathways
- HER2/EGFR in Cancer Research
- Single-cell and spatial transcriptomics
- Immune Cell Function and Interaction
- Cancer-related Molecular Pathways
- Pharmacological Effects of Natural Compounds
- Asthma and respiratory diseases
- Advanced Breast Cancer Therapies
- Aquaculture disease management and microbiota
- Immune cells in cancer
- Circular RNAs in diseases
- Prostate Cancer Treatment and Research
- Caveolin-1 and cellular processes
- RNA modifications and cancer
- Wound Healing and Treatments
- Ferroptosis and cancer prognosis
- Prostate Cancer Diagnosis and Treatment
- Breast Cancer Treatment Studies
- Monoclonal and Polyclonal Antibodies Research
- Eosinophilic Esophagitis
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Herpesvirus Infections and Treatments
- Bladder and Urothelial Cancer Treatments
Jilin University
2025
Jilin Medical University
2025
Soochow University
2023-2024
First Affiliated Hospital of Soochow University
2023-2024
Guangxi University
2020-2023
Nanjing Medical University
2020-2022
Zhongda Hospital Southeast University
2022
Jiangsu Province Hospital
2021
Kunming Medical University
2017
Abstract Accurate detection of circulating tumor cells (CTCs) in blood and non-blood body fluids enables generation deterministic cancer diagnosis represent a less invasive safer liquid biopsy approach. Although genomic alternations have been widely used DNA (ctDNA) analysis, studies on cell-based profiling for CTC are rare due to major technical limitations single-cell whole genome sequencing (WGS) including low throughput, accuracy high cost. We report low-pass WGS-based protocol...
BackgroundAllergic diseases have become one of the major public health problems to be addressed in world today. As a tissue resident cell, mast cells are crucial pathogenesis allergic diseases. Vitamin A is an important fat-soluble vitamin with immunomodulatory functions. deficiency has been shown associated disease states, including asthma; however, no studies reported on whether effect activation reactions. ObjectiveTo explore blocking retinoic acid receptors cell degranulation. Methods...
Lung cancer remains a leading cause of cancer-related mortality worldwide, with non-small cell lung (NSCLC) accounting for 85% cases. Although targeted therapies have improved treatment outcomes, drug resistance poses significant challenge, underscoring the need novel therapeutic strategies. Interleukin-33 (IL-33), member IL-1 superfamily, functions both as nuclear protein and cytokine, binding to its receptor, ST2. While IL-33 is known promote tumour migration metastasis, role in regulating...
Objective: Suppression of tumorigenicity 2 (ST2), the receptor for interleukin (IL)-33, has a critical role in tumor growth, angiogenesis, metastasis, and immune modulation. The IL-33/ST2 pathway is known to influence polarization function macrophages, which integral modulating microenvironment. However, precise tumors, particularly non-small cell lung cancer (NSCLC), not been established. Methods: ST2 expression NSCLC was analysed using murine model patient specimens. effect axis on...
Abstract Resistance to DNA damage is one of the primary mechanisms by which tumor cells evade effects standard chemotherapeutic agents and radiotherapy. Dynamic complex interactions between microenvironment (TME) critically influence response. Interleukin-33 (IL-33) a multifunctional cytokine secreted at high levels in response cellular stress. Recently, increasing evidence has suggested that IL-33 plays key role promoting therapeutic resistance tumors. However, actual source during cancer...
Interleukin-33 (IL-33) plays multifaceted roles in tumor progression, but its autocrine regulation of breast cancer stemness and metastasis via the Wnt pathway remains unclear. Here, we investigated IL-33/ST2 axis using CRISPR/Cas9, single-cell RNA sequencing, murine models (orthotopic 4T1 spontaneous MMTV-PyMT). Elevated IL-33 levels correlated with aggressive subtypes poor prognosis. overexpression enhanced proliferation, migration, stem cell (CSC) marker expression (CD44, ALDH1)...
Breast cancer is the most common worldwide. JWA a microtubule-associated protein that has been identified as tumor suppressor, and its downregulation in tumors an independent adverse prognostic factor. The objective of this study was to explore expression, regulation, mechanism trastuzumab-resistant breast cancers. In study, we found expression lower cancers than trastuzumab-sensitive Furthermore, it confirmed overexpression inhibited proliferation promoted apoptosis both vitro vivo....
Ammonia stress and nitrite can induce immune depression oxidative in Litopenaeus vannami (L. vannamei). Earlier reports showed that L. vannamei immunity, resistance to ammonia stress, improved after Tian-Dong-Tang-Gan Powder (TDTGP) treatment, but the mechanism is not clear. In this study, three thousand were fed different doses of TDTGP for 35 days then subjected treatments 72 h. Transcriptome 16-Seq ribosomal RNA gene sequencing (16S rRNA-seq) used analyze hepatopancreas expression changes...
Pseudorabies virus (PRV) infection leads to severe inflammatory responses and tissue damage, many natural herbs exhibit protective effects against viral by modulating the response. An ethyl acetate fraction of flavonoids from Polygonum hydropiper L. (FEA) was prepared through ethanol extraction fractional extraction. model established in RAW264.7 cells with PRV evaluate anti-inflammatory activity FEA measuring cell viability, nitric oxide (NO) production, reactive oxygen species (ROS)...
This study was designed to construct a prognostic risk model predict prognosis and immunotherapy response of bladder cancer (BCa) patinets. 350 differential expressed immune-related genes (DEIRGs) were obtained according the transcriptome profiling from Cancer Genome Atlas (TCGA) database ImmPort database, respectively. A constructed based on 15 hub through univariate, multivariate, LASSO Cox regression analyses. The area under receiver operating characteristic (ROC) curve 0.743, indicating...
DJ-1 is significantly elevated in various malignancies. However, the clinical significance of hormone receptor (HR)-positive (HR+) breast cancer remains unclear. We evaluated expression different databases and validated vitro assay by RT-PCR western blot among HR+ cancer. The correlations between level tumor-immune were calculated. Mutational landscape, enriched signaling pathways, drug sensitivity analyses also assessed high low-expression groups. was upregulated cancer, linked with poor...
To investigate the value of 68Ga-labeled prostate specific membrane antigen (PSMA) PET/CT for assessing tumor load in primary lesions risk stratification and predicting metastasis newly diagnosed cancer (PCa).We retrospectively analyzed data 36 patients (mean age 71.3 ± 8.6 years, range 56 to 89 years) with PCa undergoing 68Ga-PSMA-I&T from June 2018 July 2019. SUVmax SUVmean were measured, PSMA volume (PSMA-TV) total lesion (TL-PSMA) automatically measured calculated all patients. The...
Background: Early stages of lung cancer have a better prognosis than later stages. The accuracy current early detection methods is relatively poor. We firstly try to use circRNAs platelets enable blood-based cancer. Methods: did three-stage study that included healthy controls, benign nodule, and patients with diagnosed from two hospitals in China. used High-throughput Illumina sequencing analysis profile expression the 8 non-cancer controls (including nodule patients). Using training cohort...
Wound repair is a complex process involving multiple disciplines, cell factors, types, and signaling pathways. In recent years, many researches showed that circulating fibroblasts (cFbs) deriving from bone marrow residing in peripheral blood, played role wound by migrating to sites, differentiating into myofibroblasts, secreting cytokines, extracellular matrix, chemokines, growth antigen-presenting molecules, etc. cFbs also involve three phases of inflammation, proliferation, remodeling...