A5032966102- Animal Nutrition and Physiology
- Gut microbiota and health
- Microbial Metabolic Engineering and Bioproduction
- Aquaculture disease management and microbiota
- Bacteriophages and microbial interactions
- Effects of Environmental Stressors on Livestock
- Bacterial Genetics and Biotechnology
- Chromium effects and bioremediation
- Genomics and Phylogenetic Studies
- Neuropeptides and Animal Physiology
- RNA and protein synthesis mechanisms
- Microbial bioremediation and biosurfactants
- Cancer Research and Treatments
- CRISPR and Genetic Engineering
- Probiotics and Fermented Foods
- Heavy metals in environment
- Animal Behavior and Welfare Studies
- Effects and risks of endocrine disrupting chemicals
- Aquaculture Nutrition and Growth
- Enzyme Catalysis and Immobilization
- Sirtuins and Resveratrol in Medicine
- Insect Utilization and Effects
- Adipose Tissue and Metabolism
- Wastewater Treatment and Nitrogen Removal
- Protein Hydrolysis and Bioactive Peptides
Hohai University
2009-2025
East China University of Science and Technology
2016-2025
Second Xiangya Hospital of Central South University
2025
Central South University
2025
Ningbo University
2024
Guangxi University
2023-2024
Dalian Maternal and Child Health Hospital
2024
Beijing Academy of Agricultural and Forestry Sciences
2024
Institute of Plant Protection
2022-2024
Lanzhou University
2009-2024
Many Lactobacillus plantarum strains can secrete some antimicrobial substances and be added to food as agents preservatives. In this study, three L. (P1, S11, M7) with strong activity against pathogenic bacteria were isolated from Xinjiang traditional dairy products. Five common organic acids produced by fermentation of play a key role in inhibiting bacteria. At the same pH, broth Escherichia coli Salmonella is stronger than that acid alone. Thus, kinds (P1-1, M7-1, S11-1) mixed five...
Type 2 diabetes (T2D) is potentially linked to disordered tryptophan metabolism that attributes the intricate interplay among diet, gut microbiota, and host physiology. However, underlying mechanisms are substantially unknown. Comparing microbiome metabolome differences in mice fed a normal diet (ND) high-fat (HFD), we uncover microbiota–dependent metabolite 5-hydroxyindole-3-acetic acid (5-HIAA) present at lower concentrations with versus without insulin resistance. We further demonstrate...
Bacteriophages, leveraging phage display and chemical modification, have the potential to deliver large payloads of antitumor agents with precision advance vaccine development. However, systemic administration often induces neutralizing antibodies, which accelerate clearance reduce accumulation at target site. To address this limitation, we propose a genetically modified nonpathogenic bacterial strain that specifically targets tumors releases programmed death ligand 1 (PD-L1)-specific M13...
Botryosphaeriaceae are an important fungal family that cause woody plant diseases worldwide. Recent studies have established a correlation between environmental factors and disease expression; however, less is known about trigger these diseases. The current study reports on the 43.3 Mb de novo genome of Lasiodiplodia theobromae five other genomes pathogens. Botryosphaeriaceous showed expansion gene families associated with cell wall degradation, nutrient uptake, secondary metabolism membrane...
The regulatory mechanisms underlying the uptake and utilization of multiple types carbohydrates in actinomycetes remain poorly understood. In this study, we show that GlnR (central regulator nitrogen metabolism) serves as a universal metabolism plays an important, previously unknown role controlling transport non-phosphotransferase-system (PTS) carbon sources actinomycetes. It was observed can directly interact with promoters most (13 20) carbohydrate ATP-binding cassette (ABC) transporter...
Ammonia (NH3) is a known harmful gas and exists in haze, forming secondary organic aerosols. Exposure to ambient ammonia correlates with the respiratory tract infection, microbiota upper an emerging crucial player homeostatic regulation of perturbation usually accompanied by inflammatory reactions; however, effects different levels exposure on tracheal inflammation are unclear. A total 288 22-day-old male Arbor Acres broilers were chosen divided into 4 groups 6 replicates 12 chickens,...
Respiratory tract diseases are closely related to atmosphere pollution. Ammonia is one of the harmful pollutants in environment, which has a great threat human and animal respiratory health, but mechanism causing not clear. In this study, broiler lung tissue was used as model study effect high ammonia on through relationship between microflora, NLRP3 inflammasome, inflammatory factors. For this, we validated occurrence inflammation under exposure detected microbial constituent by 16S rDNA...
Radioresistance is the major factor of glioblastoma multiforme (GBM) treatment failure and relapse. Hypoxia autophagy are linked to radioresistance poor prognosis in solid tumors, but mechanisms remain unknown. Thus, we hypothesize that hypoxia may activate through two critical factors, HIF1A Beclin-1, resulting GBM vitro vivo. In this study, first demonstrated was overexpressed tissues predicted a via bioinformatics. Secondly, determined induced high expression upregulated levels Beclin-1...
Hyperuricemia, a prevalent metabolic disorder, poses susceptibility to various complications. The conventional pharmacotherapeutic approaches for hyperuricemia often entail notable adverse effects, posing substantial clinical challenges. Hence, the imperative lies in development of novel, safe and effective strategies preventing treating hyperuricemia. Here, we developed probiotic
To isolate a novel strain that could degrade many kinds PAEs efficiently and investigate the DBP-degrading pathway in this strain.Based on its 16S rRNA gene sequence, was identified as Rhizobium sp. This strain, named LMB-1, can also utilize phthalates, such DEHP, DMP, DBP DEP. During degradation of DBP, six possible metabolites, diethyl phthalate, mono-ethyl di-methyl mono-methyl phthalic acid tartaric acid, were by gas chromatography-mass spectrometry (GC-MS) analysis, study.In summary,...
The aim of the present study was to examine effect high temperature on cecal microbiota laying hens and analyze correlation between variation in feed intake, body temperature, relative abundance specific bacterial genera. Two hundred sixteen 28-wk-old Hy-Line were randomly divided into 3 groups with 6 replicates raised controlled climate chambers. Birds allocated either a thermoneutral group (TC, 21 ± 1°C, ad libitum), cyclic (HT, 29-35°C, or pair-feeding (PF, daily intake HT hens) for 4 wk....
This paper investigated the effects of heat stress on gut-microbial metabolites, gastrointestinal peptides, glycolipid metabolism, and performance broilers. Thus, 132 male Arbor Acres broilers, 28-days-old, were randomly distributed to undergo two treatments: thermoneutral control (TC, 21 °C) high temperature (HT, 31 °C). The results showed that average daily gain (ADG), feed intake (ADFI), gastric inhibitory polypeptide (GIP) concentration in jejunum significantly decreased core...
Ammonia is a known environmental pollutant that causes injury to the intestine. Growing evidence suggests intestinal microbiota dysbiosis involves in development of under pollution. However, specific mechanism remains unexplored. To do this, broiler chicken ileal exposed ammonia was selected as research object. Further, antibiotic depletion and flora transplantation were used clarify role injury. Histopathological examination indicated inhaled caused Then we observed decrease muc-2,...
Abstract Obesity and its related complications have become increasingly serious social problems that threaten people's lives. Lactic acid bacteria (LAB) shown an effective influence on preventing obesity in animal experiments human clinical trials, but exact mechanism remains unclear. In this review, LAB several of metabolites are taken as the point penetration. It is aimed to summarize relationship between gut microbiota, efficacy LAB, potential mechanisms lipid metabolism. intervention can...
Abstract This study aimed to investigate the effects of different levels protease DE200 on performance, egg quality, organ index, and cecum microflora Hy-line W36 laying hens. In this experiment, a total 180 hens aged 300 d were randomly divided into three treatment groups fed diets containing 0, 100, or 200 g/t DE200. The experimental period was 8 wk, including 2 wk prefeeding 6 formal experiment. Regular feeding performed thrice day eggs collected twice daily, feed intake quality recorded....
One of the major mechanisms that could produce resistance to antineoplastic drugs in cancer cells is ATP binding cassette (ABC) transporters. The ABC transporters can significantly decrease intracellular concentration by increasing their efflux, thereby lowering cytotoxic activity drugs. these transporters, multiple resistant protein 7 (MRP7, ABCC10), has recently been shown efflux paclitaxel. In this study, we examined effects BCR-Abl tyrosine kinase inhibitors imatinib, nilotinib and...
In cells of all domains life, reversible lysine acetylation modulates the function proteins involved in central cellular processes such as metabolism. this study, we demonstrate that nitrogen regulator GlnR actinomycete Saccharopolyspora erythraea directly regulates transcription acuA gene (SACE_5148), which encodes a Gcn5-type acetyltransferase. We found AcuA acetylates two glutamine synthetases (GlnA1 and GlnA4) inactivated GlnA4 (GSII) but had no significant effect on GlnA1 (GSI-β)...