A5100352458- melanin and skin pigmentation
- Pluripotent Stem Cells Research
- CRISPR and Genetic Engineering
- Chemokine receptors and signaling
- Mesenchymal stem cell research
- Neonatal Respiratory Health Research
- Animal Genetics and Reproduction
- Antimicrobial Peptides and Activities
- Immunotherapy and Immune Responses
- Lipid Membrane Structure and Behavior
- Advanced biosensing and bioanalysis techniques
- Corneal Surgery and Treatments
- Lymphatic System and Diseases
- Immune Response and Inflammation
- RNA Interference and Gene Delivery
- 3D Printing in Biomedical Research
- Periodontal Regeneration and Treatments
- Liver physiology and pathology
- Circadian rhythm and melatonin
- Pancreatic function and diabetes
- Wound Healing and Treatments
- Hair Growth and Disorders
- RNA regulation and disease
- T-cell and B-cell Immunology
- Skin Protection and Aging
Qingdao Municipal Hospital
2025
Jilin University
2024-2025
Jilin Medical University
2025
First Affiliated Hospital of Guangzhou Medical University
2025
Guangzhou Medical University
2025
Qingdao University
2025
Nanfang Hospital
2020-2024
Jiangsu University
2018-2024
Affiliated Hospital of Jiangsu University
2018-2024
Nanfang College Guangzhou
2024
Abstract Experimental autoimmune encephalomyelitis (EAE) is a CD4+ Th1 T cell-mediated disease of the CNS, used to study certain aspects multiple sclerosis. CXCR3, receptor for CXCL10, CXCL9, and CXCL11, preferentially expressed on activated cells has been proposed govern migration lymphocytes into inflamed CNS during sclerosis EAE. Unexpectedly, CXCL10-deficient mice were susceptible EAE, leaving uncertain what role CXCR3 its ligands might play in this model. In study, we report that...
Abstract Based on the principle of dual prediction by segment hydrophobicity and nonpolar phase helicity, in concert with imposed threshold values these two parameters, we developed automated program TM Finder that can successfully locate most transmembrane (TM) segments proteins. The uses results experiments a series host‐guest mimic peptides prototypic sequence KK AAA X AAAAA AAWAA KKKK‐amide (where = each 20 commonly occurring amino acids) through which an HPLC‐derived hydropathy scale,...
Engraftment of donor hepatocytes is a critical step that determines the success hepatocyte transplantation. Rapid and efficient integration cells would enable prompt liver repopulation these in response to selective proliferative stimuli offered by preparative regimen. We have earlier demonstrated hepatic irradiation (HIR) combination with variety hepatotrophic growth signals, such as partial hepatectomy factor, can be used regimen for transplanted hepatocytes. In this study, we investigated...
D6, a promiscuous nonsignaling chemokine binding molecule expressed on the lymphatic endothelium, internalizes and degrades CC chemokines, D6(-/-) mice demonstrated increased cutaneous inflammation following topical phorbol ester or CFA injection. We report that were unexpectedly resistant to induction of experimental autoimmune encephalomyelitis due impaired encephalitogenic responses. Following with myelin oligodendroglial glycoprotein (MOG) peptide 35-55 in CFA, showed reduced spinal cord...
Induced pluripotent stem cells (iPSCs) are a promising melanocyte source as they propagate indefinitely and can be established from patients. However, the in vivo functions of human iPSC-derived melanocytes (hiMels) remain unknown. Here, we generated hiMels vitiligo patients using three-dimensional system with enhanced differentiation efficiency, which showed characteristics epidermal high sequence similarity involved multiple vitiligo-associated signaling pathways. A modified hair follicle...
The active site cysteine of human O(6)-alkylguanine-DNA alkyltransferase (hAGT), Cys145, was shown to be highly reactive with model electrophiles unrelated substrates, including 1-chloro-2,4-dinitrobenzene. high reactivity suggested that the Cys145 thiolate anion might stable at neutral pH. pK(a) estimated from plots UV spectra (A(239)) and toward 4,4'-dithiopyridine vs for hAGT 4-5, depending upon method used, near extensively characterized papain Cys25. Rates reaction were similar forms...
To investigate the prevalence and risk factors for pterygium in rural older adults Shandong Province, eastern China, a population-based, cross-sectional study was performed from April to July 2008. By means of cluster random sampling methods, total 19,583 people aged 50 years or above were randomly selected four counties. Out people, 1,767 residents excluded mainly because they migrant workers when this performed. Finally, 17,816 (90.98%) included as eligible subjects. They received...
Abstract Early-stage lung adenocarcinoma (LUAD) generally has a favorable prognosis. However, more than 30% of early-stage LUAD cases relapse within 5 years initial treatment, even following complete removal the primary tumor. Identification factors contributing to metastasis is needed develop effective prevention and treatment strategies. Here, we found upregulation xylosyltransferase 1 (XYLT1), glycosyltransferase that initiates biosynthesis sulfated glycosaminoglycan (sGAG) chains, in...
Interleukin-33 (IL-33) plays multifaceted roles in tumor progression, but its autocrine regulation of breast cancer stemness and metastasis via the Wnt pathway remains unclear. Here, we investigated IL-33/ST2 axis using CRISPR/Cas9, single-cell RNA sequencing, murine models (orthotopic 4T1 spontaneous MMTV-PyMT). Elevated IL-33 levels correlated with aggressive subtypes poor prognosis. overexpression enhanced proliferation, migration, stem cell (CSC) marker expression (CD44, ALDH1)...
Transarterial embolization (TAE) is a palliative option commonly used for the treatment of advanced, unresectable hepatocellular carcinoma (HCC). However, patient prognosis in regards to overall survival has not improved with this method, mainly due hypoxia‑inducible factor‑1α (HIF‑1α)‑induced angiogenesis and invasiveness. Thus, it hypothesized that HIF‑1α may be an ideal knockout target HCC combination TAE. present study, was conducted human liver cancer SMMC‑7721 cells xenograft model...
Acute graft-versus-host disease (aGVHD) after allogeneic hematopoietic stem cell transplantation poses one of the most vexing challenges. Gut microbiota dysbiosis can proceed aGVHD and mesenchymal cells (MSCs) have promising therapeutic potential for aGVHD. However, whether hAMSCs affect gut during mitigation remains unknown. Accordingly, we sought to define effects underlying mechanisms human amniotic membrane-derived MSCs (hAMSCs) regulating intestinal immunity in By establishing humanized...
Background Striae gravidarum is a common skin problem of considerable cosmetic concern for many pregnant women. Various risk factors associated with the development striae have been reported, conflicting results. Objectives To analyze in Chinese primiparous women and to provide evidence relevant prevention this condition. Methods Singleton who were hospitalized delivery included, data collected. Independent those without identified using logistic regression. Results Among 213 singleton...
Daphnane diterpenoids are mainly distributed in Thymelaeaceae and Euphorbiaceae have various bioactivities. About 100 daphnane been isolated from natural plants. In this review, we systematically summarize the 13 C‐NMR data of plants over past several decades briefly discussed their biological activities basic structural–activity relationship. Copyright © 2013 John Wiley & Sons, Ltd.
Inflammation and coagulation are two important processes implicated in venous thromboembolism (VTE). 15-epi-lipoxin A4 (15-epi-LXA4) is the epimer of LXA4, a small lipid molecule, known to play key role resolution inflammation. This study aimed demonstrate whether 15-epi-LXA4 could suppress inflammatory factor tumor necrosis factor-alpha (TNF-α)-induced upregulation tissue (TF), an regulator blood cascade, evaluated possible underlying mechanisms. We found that not only reduced up-regulation...